Protein Engineering for Therapeutics, Part B

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Peptides, and Scaffolds
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Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists


Book information

  • Published: January 2012
  • ISBN: 978-0-12-396962-0

Table of Contents

Part III: Peptides

  1. Stapled Peptides for Intracellular Drug Targets
  2. Gregory L. Verdine and Gerard J. Hilinski

  3. Mapping of vascular zip codes by phage display
  4. Tambet Teesalu, Kazuki N. Sugahara & Erkki Ruoslahti

  5. Engineering cyclic peptide toxins
  6. Richard J. Clark and David J. Craik

  7. Peptide Discovery using Bacterial Display and Flow Cytometry
  8. Jennifer A. Getz, Tobias D. Schoep, Patrick S. Daugherty

    Part V: Scaffolds

  9. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
  10. Rastislav Tamaskovic, Manuel Simon, Nikolas Stefan, Martin Schwill and Andreas Plückthun

  11. Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)
  12. Shohei Koide, Akiko Koide, and Daša Lipovšek

  13. Anticalins: small engineered binding proteins based on the lipocalin scaffold
  14. Michaela Gebauer and Arne Skerra

  15. T Cell Receptor Engineering
  16. Jennifer D. Stone, Adam S. Chervin, David H. Aggen, David M. Kranz

  17. Engineering Knottins as Novel Binding Agents
  18. Sarah J. Moore and Jennifer R. Cochran

    Part VI: Pharmacokinetics

  19. Practical Theoretic Guidance for the Design of Tumor Targeting Agents
  20. K. Dane Wittrup, Greg M. Thurber, Michael M. Schmidt, John J. Rhoden

  21. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier
  22. William M. Pardridge and Ruben J. Boado

  23. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells

David B. Thompson, James J. Cronican, and David R. Liu