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Protein Engineering for Therapeutics, Part B

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Peptides, and Scaffolds

Included in series
Methods in Enzymology

Hardbound, 392 Pages

Published: January 2012

Imprint: Academic Press

ISBN: 978-0-12-396962-0

Contents

  • Part III: Peptides

    1. Stapled Peptides for Intracellular Drug Targets

      2. Gregory L. Verdine and Gerard J. Hilinski

    2. Mapping of vascular zip codes by phage display

      3. Tambet Teesalu, Kazuki N. Sugahara & Erkki Ruoslahti

    3. Engineering cyclic peptide toxins

      4. Richard J. Clark and David J. Craik

    4. Peptide Discovery using Bacterial Display and Flow Cytometry

      5. Jennifer A. Getz, Tobias D. Schoep, Patrick S. Daugherty

      Part V: Scaffolds

    5. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy

      6. Rastislav Tamaskovic, Manuel Simon, Nikolas Stefan, Martin Schwill and Andreas Plückthun

    6. Target-binding proteins based on the tenth human fibronectin type III domain ( 10 Fn3)

      7. Shohei Koide, Akiko Koide, and Daša Lipovšek

    7. Anticalins: small engineered binding proteins based on the lipocalin scaffold

      8. Michaela Gebauer and Arne Skerra

    8. T Cell Receptor Engineering

      9. Jennifer D. Stone, Adam S. Chervin, David H. Aggen, David M. Kranz

    9. Engineering Knottins as Novel Binding Agents

      10. Sarah J. Moore and Jennifer R. Cochran

      Part VI: Pharmacokinetics

    10. Practical Theoretic Guidance for the Design of Tumor Targeting Agents

      11. K. Dane Wittrup, Greg M. Thurber, Michael M. Schmidt, John J. Rhoden

    11. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier

      12. William M. Pardridge and Ruben J. Boado

    12. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells

    David B. Thompson, James J. Cronican, and David R. Liu

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