Protein Engineering for Therapeutics, Part B book cover

Protein Engineering for Therapeutics, Part B

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Peptides, and Scaffolds

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Included in series
Methods in Enzymology

Hardbound, 392 Pages

Published: January 2012

Imprint: Academic Press

ISBN: 978-0-12-396962-0


  • Part III: Peptides

    1. Stapled Peptides for Intracellular Drug Targets
      Gregory L. Verdine and Gerard J. Hilinski

    2. Mapping of vascular zip codes by phage display
      Tambet Teesalu, Kazuki N. Sugahara & Erkki Ruoslahti

    3. Engineering cyclic peptide toxins
      Richard J. Clark and David J. Craik

    4. Peptide Discovery using Bacterial Display and Flow Cytometry
      Jennifer A. Getz, Tobias D. Schoep, Patrick S. Daugherty

      Part V: Scaffolds

    5. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
      Rastislav Tamaskovic, Manuel Simon, Nikolas Stefan, Martin Schwill and Andreas Plückthun

    6. Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)
      Shohei Koide, Akiko Koide, and Daša Lipovšek

    7. Anticalins: small engineered binding proteins based on the lipocalin scaffold
      Michaela Gebauer and Arne Skerra

    8. T Cell Receptor Engineering
      Jennifer D. Stone, Adam S. Chervin, David H. Aggen, David M. Kranz

    9. Engineering Knottins as Novel Binding Agents
      Sarah J. Moore and Jennifer R. Cochran

      Part VI: Pharmacokinetics

    10. Practical Theoretic Guidance for the Design of Tumor Targeting Agents
      K. Dane Wittrup, Greg M. Thurber, Michael M. Schmidt, John J. Rhoden

    11. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier
      William M. Pardridge and Ruben J. Boado

    12. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells
      David B. Thompson, James J. Cronican, and David R. Liu


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