Protein Engineering for Therapeutics, Part A book cover

Protein Engineering for Therapeutics, Part A

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds

Audience
Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Included in series
Methods in Enzymology

Hardbound, 392 Pages

Published: January 2012

Imprint: Academic Press

ISBN: 978-0-12-416039-2

Contents

    1. Simplified Synthetic Antibody Libraries
    2. Saravanan Rajan and Sachdev S. Sidhu

    3. Generation of Dual Variable Domain Immunoglobulin Molecules for Dual-specific Targeting
    4. Jijie Gu and Tariq Ghayur

    5. Discovery of internalizing antibodies to tumor antigens from phage libraries
    6. Yu Zhou and James D Marks

    7. Optimizing properties of anti-receptor antibodies using kinetic computational models and experiments
    8. Brian D. Harms, Jeffrey D. Kearns, Stephen V. Su, Neeraj Kohli, Ulrik B. Nielsen and Birgit Schoeberl

    9. Cell-specific siRNA delivery by peptides and antibodies
    10. Sang-Kyung Lee, Alyssa Siefert, Jagadish Beloor, Tarek M Fahmy and Priti Kumar

    11. Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues
    12. Robert P. Lyon*, David L. Meyer, Jocelyn R. Setter, and Peter D. Senter

    13. Building and characterizing antibody-targeted lipidic nanotherapeutics
    14. Dmitri B. Kirpotin, Charles O. Noble, Mark E. Hayes, Zhaohua Huang, Tad Kornaga, Yu Zhou, Ulrik B. Nielsen, James D. Marks, and Daryl C. Drummond

    15. Cell-Targeting Fusion Constructs Containing Recombinant Gelonin
    16. Mi-Ae Lyu; Yu (Joshua) Cao; Khalid A. Mohamedali; and Michael G. Rosenblum

    17. Stapled Peptides for Intracellular Drug Targets
    18. Gregory L. Verdine andGerard J. Hilinski

    19. Mapping of vascular zip codes by phage display
    20. Tambet Teesalu, Kazuki N. Sugahara & Erkki Ruoslahti

    21. Engineering cyclic peptide toxins
    22. Richard J. Clark and David J. Craik

    23. Peptide Discovery using Bacterial Display and Flow Cytometry
    24. Jennifer A. Getz, Tobias D. Schoep, Patrick S. Daugherty

    25. Oral enzyme therapy for celiac sprue
    26. Michael T Bethune1 and Chaitan Khosla

    27. Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins
    28. Jo E. Lomax, ChelcieH. Eller, and Ronald T. Raines

    29. Engineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer
    30. Jason R. Cantor, Vasiliki Panayiotou, Giulia Agnello, George Georgiou and Everett M. Stone

    31. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
    32. Rastislav Tamaskovic, Manuel Simon, Nikolas Stefan, Martin Schwill and Andreas Plückthun

    33. Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)
    34. Shohei Koide, Akiko Koide, and Daša Lipovšek

    35. Anticalins: small engineered binding proteins based on the lipocalin scaffold
    36. Michaela Gebauer

    37. T Cell Receptor Engineering
    38. Jennifer D. Stone, Adam S. Chervin, David H. Aggen, David M. Kranz

    39. Engineering Knottins as Novel Binding Agents
    40. Sarah J. Moore and Jennifer R. Cochran

    41. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier
    42. William M. Pardridge and Ruben J. Boado

    43. Practical Theoretic Guidance for the Design of Tumor Targeting Agents
    44. K. Dane Wittrup, Greg M. Thurber, Michael M. Schmidt, John J. Rhoden

    45. Fusions of elastin-like polypeptides to pharmaceutical proteins
    46. Wafa Hassouneh, Sarah R Mac Ewan, Ashutosh Chilkoti

    47. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells

      David B. Thompson, James J. Cronican, and David R. Liu

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