Proteases in Health and Disease book cover

Proteases in Health and Disease

Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments.


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Hardbound, 328 Pages

Published: January 2011

Imprint: Academic Press

ISBN: 978-0-12-385504-6


    "Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal


  • Chapter 1: Membrane-Anchored Serine Proteases in Health and Disease

    by Toni M. Antalis, Thomas Bugge, and Qingyu Wu


    Chapter 2: Complex Assemblies of Factor IX and X Regulate the Initiation, Maintenance, and Shutdown of Blood Coagulation

    by Thomas Zögg and Hans Brandstetter


    Chapter 3: Structure and Proteolytic Properties of ADAMTS13, a Metalloprotease Involved in the Pathogenesis of Thrombotic Microangiopathies

    by Stefano Lancellotti and Raimondo De Cristofaro


    Chapter 4: Thrombin as an Anticoagulant

    by Enrico Di Cera


    Chapter 5: Regulation of Proteases by Protein Inhibitors of the Serpin Superfamily

    by Steven T. Olson and Peter G.W. Gettins


    Chapter 6: Multiple Roles of Metalloproteinases in Neurological Disorders

    by Yi Yang, Jeff W. Hill, and Gary A. Rosenberg


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