Proteases in Health and Disease

Edited by

  • Enrico Di Cera, Washington University School of Medicine, St. Louis, Missouri, U.S.A.

Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments.
View full description


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.


Book information

  • Published: January 2011
  • ISBN: 978-0-12-385504-6


"Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal

Table of Contents

Chapter 1: Membrane-Anchored Serine Proteases in Health and Disease

by Toni M. Antalis, Thomas Bugge, and Qingyu Wu


Chapter 2: Complex Assemblies of Factor IX and X Regulate the Initiation, Maintenance, and Shutdown of Blood Coagulation

by Thomas Zögg and Hans Brandstetter


Chapter 3: Structure and Proteolytic Properties of ADAMTS13, a Metalloprotease Involved in the Pathogenesis of Thrombotic Microangiopathies

by Stefano Lancellotti and Raimondo De Cristofaro


Chapter 4: Thrombin as an Anticoagulant

by Enrico Di Cera


Chapter 5: Regulation of Proteases by Protein Inhibitors of the Serpin Superfamily

by Steven T. Olson and Peter G.W. Gettins


Chapter 6: Multiple Roles of Metalloproteinases in Neurological Disorders

by Yi Yang, Jeff W. Hill, and Gary A. Rosenberg