Progress in Medicinal ChemistryEdited by
- F.D. King
- G. Lawton
The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are druggable, is the best starting point for improved productivity.The seven chapters of this volume describe recent progress towards drugs acting at a range of druggable targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.
Chemists, biologists, doctors, pharmacists and anyone interested in the contemporary controversy about drugs, drug firms, and the community
Progress in Medicinal Chemistry
Hardbound, 404 Pages
Published: April 2006
se for the Series: "...may the Progress in Medicinal Chemistry series continue its invaluable service..."
--Chemistry and Industry
... a valuable source of reference"
--British Medical Journal
...These volumes should be on the shelves of all specialist libraries which claim to cater for chemists, biologists, doctors and pharmacists and should be available to everyone interested in the contemporary controversy about drugs, drug firms and the community."
...the consistently high standards for this series have been maintained in the present volume. This volume should certainly take its place next to the previous volumes in this series in libraries devoted to medicinal chemistry and drug research..."
--Journal of Medicinal Chemistry
- 1. Finding Protein Kinase Hits Using Structural Information2. Blunting the Swiss Army Knife3. Peptide Deformylase Inhibitors4. Clinically Useful Vanilloid Receptor TRPV1 Antagonists5. Recent Medicinal Chemistry of the Histamine H3 Receptor6. Recent Progress in Cannabinoid research7. Oxytocin Antagonists as Potential Therapeutic Agents