Prion Diseases and Copper Metabolism book cover

Prion Diseases and Copper Metabolism

Bse, Scrapie and CJD Research

International authorities here investigate research into the prion diseases which include Scrapie of sheep, BSE the "Mad Cow" disease, and CJD one of the human diseases. The role of metals in these diseases has become of great importance, linking it with some of the changes in Alzheimer's disease. The book focuses on metabolism of copper and manganese which are found in these diseases. It stems from proceedings of the international workshop at Christ's College, Cambridge University in 2001. After an introduction on the history of research into the diseases, there are discussions on the effects of copper on biochemical properties and prion proteins of brain cells, and newer techniques for their study. There is also a section on the relationship of Alzheimers disease to prion diseases.

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Published: October 2002

Imprint: Woodhead Publishing

ISBN: 978-1-898563-87-7

Reviews

  • The best prion book ever! ...a very well researched and prepared book on the neurodegenerative conditions known as prion diseases or TSEs. …if you want an introduction to the prion diseases as a student or are a professional looking for a readable and relevant update - this is the book for you., Review by a customer on Amazon.co.uk

Contents

  • Copper - prion protein, molecular interactions; Effects of copper on the cellular trafficking and biochemical properties of the prion protein; Tracing the copper binding to the murine prion protein; Co-ordinate binding of copper to prion protein; Oxidative stress, metal ions and neurodegenerative disease; Near infrared spectroscopy for non-destructive analysis of prion protein isoforms; Prion and Alzheimer diseases; The copper binding domain of the amyloid precursor protein of Alzheimer’s disease can modulate copper homeostasis and regulate amyloid AB production; Metals modulate the aggregation and neurotoxic properties of the prion peptide PrP106-126; Human CJD and trace elements; Metals and human prion disease; Disease progression and metal aberrations; Trace elements copper and manganese in soils; Future directions for copper and the prion protein.

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