Principles of Tissue Engineering book cover

Principles of Tissue Engineering

First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. This edition includes greatly expanded focus on stem cells, including adult and embryonic stem cells and progenitor populations that may soon lead to new tissue engineering therapies for heart disease, diabetes, and a wide variety of other diseases that afflict humanity. This up-to-date coverage of stem cell biology and other emerging technologies is complemented by a series of new chapters on recent clinical experience in applying tissue engineering. The result is a comprehensive textbook that we believe will be useful to students and experts alike.

Basic and clinical researchers in fields such as biology, chemistry, materials science, and engineering with an interest in tissue engineering.


Published: August 2007

Imprint: Academic Press

ISBN: 978-0-12-370615-7


  • INTRODUCTION TO TISSUE ENGINEERING1. The History and Scope of Tissue EngineeringJoseph P. Vacanti and Charles A. Vacanti 2. The Challenge of Imitating NatureRobert M. Nerem 3. Moving into the Clinic Alan J. Russell and Timothy Bertram4. Future PerspectivesMark E. Furth and Anthony AtalaPART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION5. Molecular Biology of the CellJonathan Slack 6. Organization of Cells into Higher-Ordered Structures Jon D. Ahlstrom and Carol A. Erickson7. Dynamics of Cell-ECM InteractionsM. Petreaca and Manuela Martins-Green8. Matrix Molecules and Their LigandsBjorn Reino Olsen 9. Morphogenesis and Tissue EngineeringA.H. Reddi 10. Gene Expression, Cell Determination and DifferentiationWilliam Nikovits, Jr. and Frank E. StockdalePART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT 11. Engineering Functional TissuesLisa E. Freed and Farshid Guilak 12. Principles of Tissue Culture and Bioreactor DesignR.I. Freshney, B. Obradovic, W. Grayson, C. Cannizzaro and Gordana Vunjak-Novakovic13. Regulation of Cell Behavior by Extracellular ProteinsAmy Bradshaw and E. Helene Sage14. Growth Factors Thomas F. Deuel and Yunchao Chang15. Mechanochemical Control of Cell Fate SwitchingDonald E. Ingber PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS16. In Vivo Synthesis of Tissues and OrgansBrendan A. Harley and Ioannis V. YannasPART FOUR: MODELS FOR TISSUE ENGINEERING17. Models as Precursors for Prosthetic DevicesEugene Bell 18. Quantitative AspectsAlan J. Grodzinsky, Roger D. Kamm, and Douglas A. LauffenburgerPART FIVE: BIOMATERIALS IN TISSUE ENGINEERING19. Micro-Scale Patterning of Cells and Their Environment Xingyu Jiang, Shuichi Takayama, Robert G. Chapman, Ravi S. Kane and George M. Whitesides20. Cell Interactions with PolymersW. Mark Saltzman and Themis R. Kyriakides21. Matrix EffectsJeffrey A. Hubbell 22. Polymer Scaffold Fabrication Matthew B. Murphy and Antonios G. Mikos23. Biodegradable Polymers James M. Pachence, Michael P. Bohrer and Joachim Kohn24. Micro- and Nanofabricated ScaffoldsChristopher J. Bettinger, Jeffrey T. Borenstein and Robert Langer 25. Three-Dimensional ScaffoldsYing Luo, George Engelmayr, Debra T. Auguste, Lino da Silva Ferreira, Jeffrey M. Karp, Rajiv Saigal and Robert LangerPART SIX: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES26. Tissue Engineering and Transplantation in the FetusDario O. Fauza 27. Immunomodulation Denise L. Faustman 28. ImmunoisolationBeth A. Zielinski and Michael J. Lysaght 29. Engineering Challenges in Immunobarrier Device DevelopmentAmy S. Lewis and Clark K. ColtonPART SEVEN: STEM CELLS 30. Embryonic Stem CellsAlan Trounson31. Adult Epithelial Tissue Stem CellsChristopher S. Potten and James W. Wilson 32. Embryonic Stem Cells as a Cell Source for Tissue EngineeringAli Khademhosseini, Jeffrey M. Karp, Sharon Gerecht, Lino Ferreira, Gordana Vunjak-Novakovic and Robert Langer33. Postnatal Stem CellsPamela Gehron Robey and Paulo Bianco PART EIGHT: GENE THERAPY34. Gene TherapyRonald G. Crystal and Stefan Worgall35. Gene Delivery into Cells and TissuesAles Prokop and Jeffrey M. Davidson PART NINE: BREAST36. Breast ReconstructionLamont Cathey, Kuen Yong Lee, Walter D. Holder, David J. Mooney and Craig R. HalberstadtPART TEN: CARDIOVASCULAR SYSTEM37. Progenitor Cells and Cardiac HomeostasisAnnarosa Leri, Toru Hosoda, Marcello Rota, Claudia Bearzi, Konrad Urbanek, Roberto Bolli, Jan Kejstura and Piero Anversa38. Cardiac-Tissue EngineeringM. Radisic, H. Park and G. Vunjak-Novakovic 39. Blood Vessels Luke Brewster, Eric M. Brey and Howard P. Greisler40. Heart Valves Peter Marc Fong, Jason Park and Christopher Kane BreuerPART ELEVEN: ENDOCRINOLOGY AND METABOLISM41. Generation of Islets from Stem CellsBernat Soria, Abdelkrim Hmadcha, Francisco J. Bedoya and Juan R. Tejedo42. Bioartificial Pancreas Athanassios Sambanis 43. Engineering Pancreatic Beta-Cells Hee-Sook Jun and Ji-Won Yoon 44. Thymus and Parathyroid OrganogenesisCraig Scott Nowell, Ellen Richie, Nancy Ruth Manley and Catherine Clare BlackburnPART TWELVE: GASTROINTESTINAL SYSTEM45. Adult Stem Cells in Normal Gastrointestinal Function and Inflammatory Disease Mairi Brittan and Nicholas A. Wright46. Alimentary Tract Shaun M. Kunisaki and Joseph Vacanti47. Liver Stem CellsEric Lagasse 48. Liver Gregory H. Underhill, Salman R. Khetani, Alice A. Chen and Sangeeta N. BhatiaPART THIRTEEN: HEMATOPOIETIC SYSTEM49. Hematopoietic Stem CellsMalcolm A.S. Moore 50. Red Blood Cell Substitutes Thomas M. S. Chang 51. Lymphoid CellsUna Chen PART FOURTEEN: KIDNEY AND GENITOURINARY SYSTEM52. Stem Cells in Kidney Development and RegenerationGregory R. Dressler 53. Renal Replacement DevicesH. David Humes 54. Genitourinary System Anthony Atala PART FIFTEEN: MUSCULOSKELETAL SYSTEM55. Mesenchymal Stem CellsFaye H. Chen, Lin Song, Robert L. Mauck, Wan-Ju Li and Rocky S. Tuan56. Bone RegenerationChantal E. Holy, F. Jerry Volenec, Jeffrey Geesin and Scott P. Bruder57. Bone and Cartilage Reconstruction Wei Liu, Wenjie Zhang and Yilin Cao58. Regeneration and Replacement of the Intervertebral DiscLori A. Setton, Lawrence J. Bonassar and Koichi Masuda59. Articular Cartilage Injury Joseph A. Buckwalter, J.L. Marsh, T. Brown, A. Amendola and J.A. Martin60. Tendons and Ligaments Francine Goulet, Lucie Germain, A. Robin Poole and Francois A. Auger61. Mechanosensory Mechanisms in BoneUpma Sharma, Antonios G. Mikos and Stephen C. Cowin62. Skeletal-Tissue EngineeringMatthew D. Kwan, Derrick C. Wan and Michael T. LongakerPART SIXTEEN: NERVOUS SYSTEM63. Neural Stem Cells Lorenz Studer 64. Brain Implants Lars U. Wahlberg 65. Spinal Cord InjuryJohn W. McDonald and Daniel Becker 66. Protection and Repair of AuditionRichard Altschuler, Yehoash Raphael, David C. Martin, Jochen Schacht, David J. Anderson and Josef M. MillerPART SEVENTEEN: OPHTHALMIC APPLICATIONS67. Stem Cells in the EyeMichael E. Boulton, Julie Albon and Maria B. Grant68. Corneal-Tissue ReplacementJeffrey W. Ruberti, James D. Zieske and Vickery Trinkaus-Randall 69. Vision Enhancement SystemsGislin Dagnelie PART EIGHTEEN: ORAL/DENTAL APPLICATIONS70. Biological Tooth Replacement and RepairAnthony J. (Tony) Smith and Paul T. Sharpe71. Oral and Maxillofacial SurgerySimon Young, Kyriacos A. Athanasiou, Antonios G. Mikos and Mark Eu-Kien Wong72. Periodontal-Tissue EngineeringHai Zhang, Hanson K. Fong, William V. Giannobile and Martha J. SomermanPART NINETEEN: RESPIRATORY SYSTEM73. Progenitor Cells in the Respiratory SystemValérie Besnard and Jeffrey A. Whitsett74. Lungs Anne E. Bishop and Julia A. PolakPART TWENTY: SKIN75. Cutaneous Stem Cells George Cotsarelis 76. Wound RepairKaustabh Ghosh and Richard A.F. Clark77. Bioengineered Skin ConstructsVincent Falanga and Katie FariaPART TWENTY-ONE: CLINICAL EXPERIENCE78.Current State of Clinical Application Shaun M. Kunisaki and Dario O. Fauza79. Tissue-Engineered Skin ProductsJonathan Mansbridge 80. Tissue-Engineered Cartilage ProductsDavid W. Levine 81. Tissue-Engineered Bone ProductsJohn F. Kay 82. Tissue-Engineered Cardiovascular ProductsThomas Eschenhagen, Herrmann Reichenspurner and Wolfmram-Hubertus Zimmermann83. Tissue-Engineered Organs Steve J. Hodges and Anthony Atala PART TWENTY-TWO: REGULATION AND ETHICS84. The Tissue-Engineering IndustryMichael J. Lysaght, Elizabeth Deweerd and Ana Jaklenec85. The Regulatory Path From Concept to MarketKiki B. Hellman 86. Ethical IssuesLaurie Zoloth Epilogue Joseph P. Vacanti


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