Principles of Sex-based Differences in Physiology

Edited by

  • V. Miller, Departments of Surgery, Physiology and Biophysics, Mayo Clinic, Rochester, MN, USA
  • M. Hay, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA

Differences in physiology between men and women extend far beyond differences in reproductive functions. Medical literature abounds in descriptions of differences in prevalence, symptoms and severity of diseases between men and women including heart attack, rheumatic diseases, gastrointestinal disease and osteoporosis. Much of the information is descriptive rather than mechanistic and scattered throughout a variety of books, review articles and original papers.

This book provides a single source that summarizes current basic mechanisms of gene/hormone interactions and their subsequent impact on physiological functions. It is an ideal source material to be used in training the next generation of physician/scientists who will develop a more individualized approach to prevention, diagnosis and therapeutic medical practice.

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Book information

  • Published: March 2004
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-51497-4

Table of Contents

Introduction (V.M. Miller, M. Hay). Forward/Historical Overview (S. Marts, S. Keitt). Section 1. Genetic control. Sex chromosomes (M.E. Turner, C. Jenkins et al.). Endocrine control of sexual differentiation: Effects of the maternal-fetal environment and endocrine disrupting chemicals (S.C. Nagel, F.S. vom Saal). Section 2. Hormonal receptors. General mechanisms of steroid receptors and receptor co-regulator action (D.G. Monroe, T.C. Spelsberg). Non-genomic actions of hormones (R.H. Karas). Hormone receptor polymorphisms (A.M. Shearman). Section 3. Integrated systems. Cardiovascular system. Sex, hormones and the endothelium (S.J. Murphy, M.T. Littleton-Kearney et al.). Sex hormones and vascular smooth muscle (J.M. Orshal, R.A. Khalil). Cardiovascular membrane excitability and the influence of sex and sex steroids (D.K. Bowles, M. Hay). Sex-differences in electrophysiology of the heart and cardiac arrhythmias (T.V. Pham, M.R. Rosen). Sex-differences in cardiac muscle and remodeling (B.L. Stauffer, L.A. Leinwand). Reflex control of the circulation (C.T. Minson). Sex differences in hypertension and renal injury (J. F. Reckelhoff, L.A. Fortepiani et al.). Musculoskeletal system and metabolism. Influence of sex hormones on the neuromuscular junction (G.C. Sieck, C.B. Mantilla). Sex and hormonal influences on skeletal muscle, differentiation and contractile mechanisms (M. Brown). Sex-based differences in substrate metabolism (T. Horton, B. Braun). Sex-differences in skeletal development (L.A. Fitzpatrick). Neurological effects. Sex differences in steroid-induced synaptic plasticity (R.D. Romeo, B.S. McEwen). Hormones and the developing brain (M.M. McCarthy). Mechanisms of sex-based neuropathologies (P.M. Wise, D.B. Dubal et al.). Immunological response, hemostasis and wound healing. Sex differences in autoimmunity (T.F. Fagan, D.L. Faustman). Influence of hormones and sex on platelet functions (M. Jayachandran, V.M. Miller). Sex differences in wound healing (G.S. Ashcroft).