Principles of Regenerative Medicine

Edited by

  • Anthony Atala, Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
  • Anthony Atala, Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
  • Robert Lanza, Advanced Cell Technology, MA, USA
  • James Thomson, Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA
  • Robert Nerem

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.
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Advanced researchers in bioengineering, stem cell biology, and developmental biology.


Book information

  • Published: December 2010
  • ISBN: 978-0-12-381422-7

Table of Contents

1 Molecular Organization of Cells
2 Cell-ECM interactions In Repair and Regeneration
3 Developmental Mechanisms of Regeneration
4 The molecular basis of pluripotency in Principles of Regenerative Medicine
5 How cells change their phenotype
6 Scarless Wound Healing
7 Somatic Cloning and Epigenetic Reprogramming in Mammals
8 Engineered Proteins for Manipulating Gene Expression and Genome Sequence
9 Genetic Approaches in Human Embryonic Stem Cells and Their Derivatives
10 Embryonic Stem Cells: Derivation and Properties
11 Alternate Sources of human embryonic stem cells
12 Stem cells derived from amniotic fluid and placenta
13 Induced Pluripotent stem cells
14 Mesenchymal Stem cells Derived from Bone Marrow
15 Multipotent adult progenitor cells
16 Mesenchymal Stem cells
17 Hepatic Stem Cells and Therapy
18 Cardiac stem cells
19 Skeletal muscle stem cells
20 Stem Cells Derived from Fat
21 Stem Cells Derived from Peripheral Blood
22 Islet Cell Therapy and Pancreatic Stem Cells
23 Regenerative Medicine for Diseases of the Retina
24 Somatic cells: Growth and expansion potential of T Lymphocytes
25 Mechanical  Determinants of Tissue Development
26 Morphogenesis and Morphogenic Proteins
27 Physical stress as a factor in tissue growth and remodeling
28 Intelligent Surfaces for Cell Sheet Engineering
29 Applications of Nanotechnology in Regenerative Medicine
30 Design Principles in Biomaterials and Scaffolds
31 Natural Origin Materials- Processing, Modification and Performance
32 Synthetic Polymers
33 Collagen Based Scaffold Materials
34 Hydrogels
35 Surface Modification of Biomaterials
36 Histogenesis in Three-Dimensional Scaffolds
37 Biocompatibility and Bioresponse to biomaterials
38 Mechano-inducible systems for stem cells
39 Biomineralization and Bone Regeneration
40 Cell therapy for blood substitutes
41 Articular Cartilage
42 Implantation of Myogenic Cells in Skeletal Muscles
43 Clinical islet transplantation
44 Fetal Tissues
45 Engineering of Large Diameter Vessels
46 Engineering of Small Diameter Vessels
47 Cardiac Tissue
48 Regenerative Medicine in the Cornea
49 Alimentary Tract
50 Extracorporeal Kidney Support
51 Tissue Engineering of the Reproductive System
52 Cartilage Tissue Engineering
53 Functional Tissue Engineering of Ligament and Tendon Injuries
54 Central Nervous System
55 Peripheral Nervous System

56 Tissue Engineeing of Skin
57 Tissue Engineering of the Respiratory Tree
58 Ethical Considerations
59 US Stem Cell Research Policy
60 Overview of FDA Regulatory Process