Principles of Molecular Virology book cover

Principles of Molecular Virology

The fifth edition of the highly successful Principles of Molecular Virology takes on a molecular approach to the explanation of virology, presenting basic in a clear, concise and student-friendly manner. This fully updated undergraduate text explores and explains the fundamental aspects of virology, including structure of virus particles and genome, replication, gene expression, infection, pathogenesis and subviral agents. A website with self-assessment questions and other resources aids in student understanding.

Undergraduates and graduates in virology, molecular biology and microbiology; Medical students and infectious disease clinicians and immunologists; Those entering the virology research area, including plant virology and AIDS research

Paperback, 320 Pages

Published: September 2011

Imprint: Academic Press

ISBN: 978-0-12-384939-7


  • Praise for previous editions:
    “An excellent virological text for students. It is recommended in many university undergraduate courses for good reason. It is well written in an accessible style... well illustrated…I suspect the self assessment questions will be usefully plundered by those setting examinations.” - Trends in Genetics
    “Excellent.. The writing flows easily with good practical examples... an attractive, up-to-date book and is an excellent buy that I can strongly recommend.” - Society for General Microbiology Quarterly
    "More suitable for an undergraduate class than any other text I have recently seen... readable and undergraduate-friendly, and it fills a definite niche.” - American Society for Microbiology News
    "Compact... and realistically priced... Present(s) molecular virology to an undergraduate audience is an easily digestible form.” - Trends in Microbiology


  • Chapter 1 Introduction

    Viruses are Distinct from Living Organisms

    The History of Virology

    Living Host Systems

    Cell Culture Methods

    Serological/Immunological Methods

    Ultrastructural Studies

    ‘Molecular Biology’

    Further Reading

    Chapter 2 Particles

    The Function and Formation of Virus Particles

    Capsid Symmetry and Virus Architecture

    Helical capsids

    Icosahedral (isometric) capsids

    Enveloped Viruses

    Complex Virus Structures

    Protein-Nucleic Acid Interactions and Genome Packaging

    Virus Receptors - Recognition and Binding

    Other Interactions of the Virus Capsid with the Host Cell


    Further Reading

    Chapter 3 Genomes

    The Structure and Complexity of Virus Genomes

    Molecular Genetics

    Virus Genetics

    Virus Mutants

    Types of mutant virus


    Genetic Interactions between Viruses

    Non-genetic Interactions between Viruses

    ‘Large’ DNA Genomes

    ‘Small’ DNA Genomes

    Positive-Strand RNA Viruses

    Negative-Strand RNA Viruses

    Segmented and Multipartite Virus Genomes

    Reverse Transcription and Transposition

    Evolution and Epidemiology


    Further Reading

    Chapter 4 Replication

    Overview of Virus Replication

    Investigation of Virus Replication

    The Replication Cycle


    Further Reading

    Chapter 5 Expression

    Expression of Genetic Information

    Control of Prokaryote Gene Expression

    Control of Expression in Bacteriophage ë

    Control of Eukaryote Gene Expression

    Genome Coding Strategies

    Transcriptional Control of Expression

    Post-Transcriptional Control of Expression


    Further Reading

    Chapter 6 Infection

    Virus Infections of Plants

    Immune Responses to Virus Infections in Animals

    Virus-Host Interactions

    The Course of Virus Infections

    Prevention and Therapy of Virus Infection

    Virus Vectors and Gene Therapy

    Chemotherapy of Virus Infections


    Further Reading

    Chapter 7 Pathogenesis

    Mechanisms of Cellular Injury

    Viruses and Immunodeficiency

    Virus-Related Diseases

    Bacteriophages and Human Disease

    Cell Transformation by Viruses

    Viruses and Cancer

    New and Emergent Viruses




    Further Reading

    Chapter 8 Subviral Agents: Genomes Without Viruses, Viruses Without Genomes

    Satellites and Viroids



    Further Reading

    Appendix 1 Glossary and Abbreviations

    Appendix 2 Classification of Subcellular Infectious Agents

    Appendix 3 The History of Virology



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