Principles of Molecular Virology

Alan J. Cann, Department of Microbiology and Immunology, University of Leicester, U.K.

The fifth edition of the highly successful Principles of Molecular Virology takes on a molecular approach to the explanation of virology, presenting basic in a clear, concise and student-friendly manner. This fully updated undergraduate text explores and explains the fundamental aspects of virology, including structure of virus particles and genome, replication, gene expression, infection, pathogenesis and subviral agents. A website with self-assessment questions and other resources aids in student understanding.

Audience
Undergraduates and graduates in virology, molecular biology and microbiology; Medical students and infectious disease clinicians and immunologists; Those entering the virology research area, including plant virology and AIDS research

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Paperback, 320 Pages

Published: September 2011

Imprint: Academic Press

ISBN: 978-0-12-384939-7

Chapter 1 Introduction
Viruses are Distinct from Living Organisms
The History of Virology
Living Host Systems
Cell Culture Methods
Serological/Immunological Methods
Ultrastructural Studies
Molecular Biology
Further Reading
Chapter 2 Particles
The Function and Formation of Virus Particles
Capsid Symmetry and Virus Architecture
Helical capsids
Icosahedral (isometric) capsids
Enveloped Viruses
Complex Virus Structures
Protein-Nucleic Acid Interactions and Genome Packaging
Virus Receptors - Recognition and Binding
Other Interactions of the Virus Capsid with the Host Cell
Summary
Further Reading
Chapter 3 Genomes
The Structure and Complexity of Virus Genomes
Molecular Genetics
Virus Genetics
Virus Mutants
Types of mutant virus
Suppression
Genetic Interactions between Viruses
Non-genetic Interactions between Viruses
Large DNA Genomes
Small DNA Genomes
Positive-Strand RNA Viruses
Negative-Strand RNA Viruses
Segmented and Multipartite Virus Genomes
Reverse Transcription and Transposition
Evolution and Epidemiology
Summary
Further Reading
Chapter 4 Replication
Overview of Virus Replication
Investigation of Virus Replication
The Replication Cycle
Summary
Further Reading
Chapter 5 Expression
Expression of Genetic Information
Control of Prokaryote Gene Expression
Control of Expression in Bacteriophage ë
Control of Eukaryote Gene Expression
Genome Coding Strategies
Transcriptional Control of Expression
Post-Transcriptional Control of Expression
Summary
Further Reading
Chapter 6 Infection
Virus Infections of Plants
Immune Responses to Virus Infections in Animals
Virus-Host Interactions
The Course of Virus Infections
Prevention and Therapy of Virus Infection
Virus Vectors and Gene Therapy
Chemotherapy of Virus Infections
Summary
Further Reading
Chapter 7 Pathogenesis
Mechanisms of Cellular Injury
Viruses and Immunodeficiency
Virus-Related Diseases
Bacteriophages and Human Disease
Cell Transformation by Viruses
Viruses and Cancer
New and Emergent Viruses
Zoonoses
Bioterrorism
Summary
Further Reading
Chapter 8 Subviral Agents: Genomes Without Viruses, Viruses Without Genomes
Satellites and Viroids
Prions
Summary
Further Reading
Appendix 1 Glossary and Abbreviations
Appendix 2 Classification of Subcellular Infectious Agents
Appendix 3 The History of Virology
Index

Principles of Molecular Virology

Contents