Principles of Laboratory Animal Science, Revised Edition

A contribution to the humane use and care of animals and to the quality of experimental results

Edited by

  • L. F. van Zutphen, Utrecht University, Department of Veterinary Science, Utrecht, The Netherlands
  • V. Baumans
  • A. C. Beynen, Department of Laboratory Animal Science, Utrecht University, Utrecht, The Netherlands

The welfare of laboratory animals, as well as the ethical issues involved in the humane use of animals for scientific purposes, are discussed in this new revised edition. Information is included on the biology and husbandry of animal models; on behavior, stress and well-being; genetic and microbiological standardization; health monitoring; anaesthesiology; animal alternatives; ethics. This book addresses all of the aspects that scientists need to know when considering the design of an animal experiment. Replacement, reduction and refinement of animal experiments are the guiding principles for its contents.
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Book information

  • Published: May 2001
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-50612-2


...This text clearly passed the 'desert island' test: it is a high-quality contribution which could stand alone as the basic, core reference text to ensure good science and welfare practice, and which should be found in any laboratory using animals in research.
T. Morris, Animal Welfare, 2002

...this book seems to me to be an extremely useful, perhaps an essential, introduction to the responsibility and process of the use of animals in research, for all those intending to embark on such a journey. Every institution where such research is conducted should have a copy on the shelf as a constant reference.
S.J. Atkinson, Australian Veterinary Journal, 2002
...this book gives valuable information and guidance for proper conduct of pharmacological or toxicological experimentation in animals. ... very useful as teaching material for courses in laboratory animal science for scientists. ...I strongly recommend this book to teachers and colleagues in in vivo pharmacology and toxicology.
Pharmacology & Toxicology, 2003

Table of Contents

Preface. Contributors. Introduction (L.F.M. van Zutphen). Legislation and animal experimentation (P.C.M. de Greeve, J. Hampson, L.F.M. van Zutphen). Biology and husbandry of laboratory animals (R. Havenaar, J.C. Meijer, D.B. Morton, J. Ritskes-Hoitinga, P. Zwart). Behaviour, stress and well-being (J.M. Koolhaas, V. Baumans, H.J.M. Blom, D. von Holst, P.J.A. Timmermans, P.R. Wiepkema). Standardization of animal experimentation (A.C. Beynen, K. Gärtner, L.F.M. van Zutphen). Nutrition and experimental results (A.C. Beynen, M.E. Coates). Genetic standardization (L.F.M. van Zutphen, H.J. Hedrich, H.A. van Lith, J.B. Prins). Microbiological standardization (R. Boot, J.P. Koopman, I. Kunstýl). Diseases of laboratory animals (J.E. van Dijk, H. van Herck, M.C. Bosland). Animal models (A.C. Beynen, J. Hau). Phases in an animal experiment (A.C. Beynen, M.F.W. Festing). Design of animal experiments (A.C. Beynen, M.F.W. Festing, M.A.J. van Montfort). Organization and management of animal experiments (A.E.J.M. van den Bogaard, R. Fosse, R.G.M. ten Berg, J.T.W.A. Strik). Recognition of pain and distress ((V. Baumans, P.F. Brain). Anaesthesia, analgesia and euthanasia (L.J. Hellebrekers, L.H.D.J. Booij, P. Flecknell). Experimental procedures (V. Baumans, R. Remie, H.J. Hackbarth, A. Timmerman). Reduction and replacement concepts in animal experimentation (J. Nab, M. Balls, J.B.F. van der Valk, C.F.M. Hendriksen). Ethical aspects of animal experimentation (Tj. de Cock Buning, F.R. Heeger, H. Verhoog). Annex. Index.