Principles of Developmental Genetics book cover

Principles of Developmental Genetics

Providing expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries of major takeaways and clinical pathways assist comprehension and readability of the highly complex content.


Basic cell and developmental biologists, developmental geneticists, stem cell biologists, clinical scientists and evo-devo biologists.

Hardbound, 784 Pages

Published: September 2014

Imprint: Academic Press

ISBN: 978-0-12-405945-0


  • Section I: Emerging Technologies and Systems Biology
    1. Untangling the Gordian knot: Cell signaling events that instruct development
    2. RNA-seq and deep sequencing
    3. Using mutagenesis in mice and zebrafish for developmental gene discovery
    4. Chemical approaches to control stem cell fate
    5. BMP signaling and stem cell self-renewal in the Drosophila ovary
    6. Genomic Analyses of Neural Stem Cells
    7. Chordate origins, stem cells and regeneration

    Section II: Early Embryology and Morphogenesis
    8. Dorsal-ventral axis patterning in insects
    9. Building dimorphic forms: an examination of the genetic pathways that intersect embryonic patterning and sex determination
    10. Anterior-Posterior patterning in mammals
    11. Early development of epidermis and neural tissue
    12. Taking the middle road: mesoderm induction and the blastula-gastrula transition
    13. Endoderm induction
    14. Epithelial branching: mechanisms of patterning and self-organization
    15. Lateral line migration

    Section III: Organogenesis
    16. Neural cell fate determination
    17. Retinal development
    18. Neural crest determination
    19. Determination of preplacodal ectoderm and sensory placodes
    20. Olfactory development
    21. Inner ear development
    22. Molecular genetics of tooth development
    23. Induction of the cardiac lineages
    24. Blood vessel formation
    25. Blood induction and embryonic formation
    26. Vertebrate kidney formation: a comparative perspective
    27. Development of the genital system
    28. Skeletal  development
    29. Formation of vertebrate limbs
    30. Patterning the embryonic endoderm into presumptive organ domains
    31. Pancreas Development and Regeneration

    Section IV: Selected Clinical Problems
    32. Diaphragmatic embryogenesis and human congenital diaphragmatic defects
    33. Genetic and developmental basis of congenital cardiovascular malformations
    34. Multiple Roles of T-box genes
    35. Craniofacial syndromes: etiology, impact and treatment
    36. DeGeorge and related syndromes
    37. Neural tube defects


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