Principles of Clinical PharmacologyEdited by
- Arthur Atkinson, Jr., Northwestern University, Chicago, Illinois , U.S.A.
- Shiew-Mei Huang, FDA, Silver Spring, Maryland, U.S.A.
- Juan Lertora, NIH Clinical Center, Bethesda, MD, U.S.A.
- Sanford Markey, National Institute of Mental Health, Bethesda, Maryland, U.S.A.
Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.
Clinical pharmacologists, pharmacologists, clinicians and scientists working in the pharmaceutical industry and government regulatory agencies
Hardbound, 652 Pages
Published: September 2012
Imprint: Academic Press
"Recent advances in pharmacogenetics, membrane transport, and biotechnology warrant a second edition of this excellent book...This will serve as an excellent text for an advanced course in principles of clinical pharmacology for graduate students, physicians, and PharmDs. Because of recent advances, the second edition is welcome." - Thomas L. Pazdernik, PhD, University of Kansas Medical Center, FOR DOODY'S (4 Stars)
- Tentative TOC:Chapter 1 Introduction PART 1: PHARMACOKINETICS:Chapter 2 Clinical pharmacokinetics Chapter 3 Compartmental analysis of drug distribution Chapter 4 Drug absorption and bioavailability Chapter 5 Effects of renal disease on pharmacokineticsChapter 6 Kinetics of hemodialysis and hemofiltrationChapter 7 Effects of liver disease on pharmacokineticsChapter 8 Noncompartmental vs. compartmental approaches to pharmacokinetic analysisChapter 9 Distributed models of drug kineticsChapter 10 Population pharmacokineticsPART 2: DRUG METABOLISM AND TRANSPORT:Chapter 11 Pathways of drug metabolismChapter 12 Biochemical mechanisms of drug toxicityChapter 13 Chemical assay of drugs and drug metabolitesChapter 14 Equilibrative and concentrative transportChapter 15 PharmacogeneticsChapter 16 Drug interactionsPART 3: ASSESSMENT OF DRUG EFFECTS:Chapter 17 Physiological and laboratory markers of drug effectChapter 18 Dose response and concentration response analysisChapter 19 Kinetics of pharmacologic effectChapter 20 Disease progression models PART 4: OPTIMIZING AND EVALUATING PATIENT THERAPY:Chapter 21 Sex differences in pharmacokinetics and pharmacodynamicsChapter 22 Drug therapy in pregnant and nursing womenChapter 23 Drug therapy in neonates and pediatric patientsChapter 24 Drug therapy in the elderlyChapter 25 Clinical analysis of adverse drug reactionsChapter 26 Quality assessment of drug therapyPART 5: DRUG DISCOVERY AND DEVELOPMENT:Chapter 27 Project managementChapter 28 Drug discoveryChapter 29 Pre-clinical developmentChapter 30 Animal scale upChapter 31 Phase I studiesChapter 32 PK and PD considerations in the development of biotechnology products and large moleculesChapter 33 Design of clinical development programsChapter 34 Good design practices for clinical trials Chapter 35 Role of the FDA in guiding drug developmentAppendix I Table of Laplace TransformsAppendix II Answers to Study Problems