Principles of Behavioral Genetics book cover

Principles of Behavioral Genetics

Principles of Behavioral Genetics presents the field of behavioral genetics. It emphasizes unifying principles, which, as a comprehensive discipline, encompasses not only studies of model organisms but the study of people, as well. Along with addressing behavior as a consequence of genetics, the book demonstrates the neurobiological and ecological aspects of behavioral genetics. In addition, it discusses evolutionary genetics and gene flow populations in relation to behavioral genetics. The book starts by discussing the history of the young field of behavioral genetics, and it continues with a description of the fundamental functions and the organization of the nervous system. The book goes on to offer basic topics related to quantitative genetic principles, and it focuses on a wide range of commonly studied behaviors, including chemoreception, circadian activity and sleep, social behaviors, locomotion, learning and memory, and addiction. This book will be a valuable resource for future generations of scientists who focus on the field of behavioral genetics.

Audience
Advanced undergraduate and graduate students in genetics, neuroscience, or ecology courses on behavior.

Paperback, 334 Pages

Published: September 2009

Imprint: Academic Press

ISBN: 978-0-12-372575-2

Contents


  • Preface

    Chapter 1: Introduction and Historical Perspective

    Overview

    The Rise of the Modern Field of Behavioral Genetics

    The Modern Evolutionary Synthesis

    The Rise of Molecular Genetics

    A Brief History of Neuroscience

    The Emergence of Behavioral Genetics

    Summary

    Study Questions

    Recommended Reading

    Chapter 2: Mechanisms of Neural Communication

    Overview

    Transmission of Information in the Nervous System

    The Resting Membrane Potential

    The Mechanism of the Action Potential

    Ion Channels, G-protein-coupled Receptors, and Signal Transduction

    Summary

    Study Questions

    Recommended Reading

    Chapter 3: Functional Organization of the Nervous System

    Overview

    The Organization of the Mammalian Nervous System

    Communication between the Brain and the Periphery

    Organization of the Nervous System in Insects

    Neurotransmitters

    Summary

    Study Questions

    Recommended Reading

    Chapter 4: Measuring Behavior: Sources of Genetic and Environmental Variation

    Overview

    Behavioral Assays

    Controlling Experimental Variation

    Sources of Variation in Behavior

    Effects of Mutations on Behavioral Phenotypes

    Environmental Variation

    Gene - Environment Correlation and Interaction

    Summary

    Study Questions

    Recommended Reading

    Chapter 5: Mapping Genotype to Phenotype in Populations

    Overview

    Genes in Populations: Random Mating

    Genes in Populations: Inbreeding

    Quantitative Genetic Model

    Summary

    Study Questions

    Recommended Reading

    Chapter 6: Partitioning Phenotypic Variance and Heritability

    Overview

    Components of Variance in Random Mating Populations

    Genotype-Environment Correlation and Interaction

    Partitioning Phenotypic Variance

    Heritability : The Concept

    Controlling and Estimating Environmental Components of Variation

    Summary

    Study Questions

    Recommended Reading

    Chapter 7: Estimating Heritability

    Overview

    Phenotypic Resemblance between Relatives

    Genetic Causes of Covariance between Relatives

    Environmental Causes of the Relationship between Relatives

    Heritability Estimates in Humans

    Heritability in Other Populations

    Estimates of Heritability for Behavioral Traits

    Summary

    Study Questions

    Recommended Reading

    Chapter 8: Quantitative Trait Locus Mapping

    Overview

    Linkage Mapping

    Interval Mapping

    Statistical Analysis

    Association Mapping

    Quantitative Trait Locus End Game

    Summary

    Study Questions

    Recommended Reading

    Chapter 9: Mutagenesis and Transgenesis

    Overview

    The Occurrence or Induction of Mutations

    Homologous Recombination

    Transposon -mediated Mutagenesis

    The GAL4-UAS Binary Expression System in Drosophila

    RNA Interference

    Summary

    Study Questions

    Recommended Reading

    Chapter 10: Genomics Approaches in Behavioral Genetics

    Overview

    Detecting Large-scale Gene Expression

    Parallel Sequencing and Transcriptional Analysis

    Plasticity of Transcriptional Profiles

    Analysis of Whole-genome Expression Microarray

    Defining Statistical Signifi cance Threshold

    Identifying Genetic Networks

    Summary

    Study Questions

    Recommended Reading

    Chapter 11: Neurogenetics of Activity and Sleep

    Overview

    Locomotion

    Genetics of Human Locomotion Disorders

    Circadian Rhythms

    Sleep

    Summary

    Study Questions

    Recommended Reading

    Chapter 12: Genetics of Social Interactions

    Overview

    Social Environment and the Genes-Brain-Behavior Paradigm

    Social Cooperation and Fitness

    Courtship and Mate Selection

    Affiliative Behavior

    Aggression and the Establishment of Social Hierarchies

    Division of Labor: The Genetics of Social Structure

    Aggregation Behavior

    Summary

    Study Questions

    Recommended Reading

    Chapter 13: Genetics of Olfaction and Taste

    Overview

    The Study of Olfaction

    The Discovery of Odorant Receptors

    Transgenic Approaches to Determine Odorant Receptor Response Profiles

    Transgenic Approaches to Map Projection Patterns of Olfactory Sensory Neurons

    The Use of Transgenic Reporter Genes to Visualize Odor Coding

    Taste and Gustatory Receptors

    Summary

    Study Questions

    Recommended Reading

    Chapter 14: Learning and Memory

    Overview

    Forming Memories

    Memory Formation: Cellular Mechanisms

    Harnessing the Power of Genetics: Learning in Drosophila

    Identifying Genetic Networks for Learning and Memory

    Learning Disabilities

    Neurodegeneration and Memory Impairment: Alzheimer’s Disease

    Summary

    Study Questions

    Recommended Reading

    Chapter 15: Genetics of Addiction

    Overview

    Hallmarks of Addiction

    Alcoholism

    Linkage and Association Studies

    Alcohol Sensitivity in Model Organisms

    Alcohol-related Phenotypes in Rodent Models

    Smoking

    Drug Addiction

    Summary

    Study Questions

    Recommended Reading

    Chapter 16: Evolution of Behavior

    Overview

    Population Genetics and Evolution

    Models of Evolution

    Selection Models

    Assessing Deviations from Neutrality

    Behavior as a Vehicle for Evolution

    Insect-Host Plant Interactions: An Example of Evolutionary Adaptation

    Co-evolution of Sexual Communication Systems

    Study Questions

    Recommended Reading

    Chapter 16: Evolution of Behavior

    Overview

    Population Genetics and Evolution

    Models of Evolution

    Selection Models

    Assessing Deviations from Neutrality

    Behavior as a Vehicle for Evolution

    Insect-Host Plant Interactions: An Example of Evolutionary Adaptation

    Co-evolution of Sexual Communication Systems

    The Evolutionary Genetics of Burrowing and Nest Building

    The Astounding Diversity of Cichlids and Sticklebacks

    Understanding the Evolution of Behavior: How Much Do We Really Know?

    Summary

    Study Questions

    Recommended Reading

    Glossary

    Index


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