Principles and Methods of Immunotoxicology


  • Jacques Descotes, Lyon Poison Center, Pharmacovigilance Unit, Lyon, France

This third thoroughly revised edition, written by a renowned expert in this rapidly expanding field, is a welcome and timely publication in the field of experimental and clinical immunotoxicology.

Immunotoxicology is a young, but rapidly expanding area of toxicology. Since the second edition of this book was published in 1988, an increasing amount of data has resulted in the publication of many articles and reviews.

This book covers the many general facets of current immunotoxicology - clinical, experimental, mechanistic and regulatory aspects, including a chapter on the immune system giving toxicologists unfamiliar with immunology the opportunity to acquire the minimal knowledge necessary to conduct and interpret immunotoxicity studies.

A comprehensive chapter on adverse effects in relation to immunotoxicity is included in order to predict and understand the toxic effects of drugs and other chemicals in living beings.An effort is made to answer one of the perhaps most confusing issues confronting the student of immunotoxicology namely the identification of what constitutes an immunotoxic response and what does not.

Researchers from different disciplines have shown interest in this new field, and presented results of their work on immunotoxicological issues from extremely varied perspectives. As a bridging discipline between immunology and toxicology, immunotoxicology is genuinely multidisciplinary, reflected in this excellent book.

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Book information

  • Published: October 2004
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-51093-8

Table of Contents

Preface. 1. Definition, history and scope of immunotoxicology. Definition of immunotoxicology. A short history of immunotoxicology. First phase: the "prehistorical phase". The scope of immunotoxicology. References. 2. The immune system: a toxicologist's overview. Introduction. The lymphoid organs. Immunocompetent cells. Innate (natural) immunity. Adaptive (specific) immunity. External influences on the immune system. Conclusion. References. 3. Health consequences of immunotoxicity. Introduction. Immunosuppression. Hypersensitivity. Autoimmunity. Conclusion. References. 4. Mechanisms of immunotoxicity. Introduction. Mechanisms of immunosuppression. Mechanisms of immunostimulation. Mechanisms of hypersensitivity reactions. Mechanisms of autoimmune reactions. Structure/immunotoxicity relationships. Conclusion. References. 5. Non clinical evaluation of unexpected immunosuppression. Introduction. Histopathology. Measurement of humoral immunity. Measurement of cellular immunity. Measurement of innate immunity. Host resistance models. Conclusion. References. 6. Non clinical evaluation of unexpected immunostimulation. Introduction. Histopathology. Immune function assays. Host resistance models. Immunosuppression and immunostimulation. Conclusion. References. 7. Non clinical evaluation of the potential for hypersensitivity. Introduction. Prediction of immune-mediated hypersensitivity. Prediction of pseudoallergy. Conclusion. References. 8. Non clinical evaluation of the potential for autoimmunity. Introduction. Systemic autoimmune reactions. Organ-specific autoimmune reactions. Autoantibodies in conventional toxicity studies. Conclusion. References. 9. Regulatory aspects of immunotoxicity evaluation. Introduction. Early immunotoxicity regulations. Recent immunotoxicity guidelines. Conclusion. References. 10. Non clinical strategies of immunotoxicity evaluation and risk assessment. Introduction. Good laboratory practices in immunotoxicity evaluation. Strategies for the prediction of immunosuppression. Strategies for the prediction of immunostimulation. Strategies for the prediction of hypersensitivity. Strategies for the prediction of autoimmune reactions. Risk assessment. Conclusion. References. 11. Clinical immunotoxicology. Introduction. Objectives of clinical immunotoxicology. Validation of non clinical immunotoxicity assays and animal models. Clinical assessment of immunotoxicity. Biomarkers of immunotoxicity. Environmental epidemiology studies. Disease clusters and sentinel diseases. Conclusion. References. 12. Immunotherapy of human poisonings. Introduction. Experimental studies. Clinical studies. Mechanisms of the efficacy of specific antibodies. Perspectives and conclusion. References. 13. Chemical immunoteratology and developmental immunotoxicology. Introduction. Immunity in newborns. Chemical teratogens and the lymphoid system. Developmental immunotoxicants. Conclusion. References. 14. Immunotoxicity and wildlife. Introduction. Immunotoxicity in fish. Immunotoxicity in marine animals. Immunotoxicity in birds. Conclusion. References. 15. New methods in immunotoxicology. Introduction. Enhanced pathology. In vitro immunotoxicology. In silico immunotoxicology. New animal models. Computational immunotoxicology. Conclusion. References. 16. Proposed classification of immunotoxicants. Introduction. Selected criteria. Proposed classification. Examples. Discussion. References.