Presynaptic Receptors and Neuronal Transporters
- S.Z. Langer
- A.M. Galzin, Synthelabo-Recherche (LERS), Paris, France
- J. Costentin, University of Rouen, St. Etienne du Rourray, France
The role of neuronal transporters in the inactivation of monoamine neurotransmitters and GABA following their release from nerve terminals has been established for at least 30 years. It is, however, during the past 10 years that receptor binding techniques have been used to label with high affinity the sodium-dependent transporter for serotonin and subsequently, that of other monoamine transmitters. This volume reviews the considerable advances in the field made since the first International Symposium on Presynaptic Receptors, and provides new insights into the function of presynaptic and neuronal transporters both in the periphery and in the CNS, with their ubiquitous locations and physiological roles. The first section deals with the extensive and still increasing list of presynaptic release-modulating auto- and heteroreceptors, and the different articles represent the current state of the art in the field of presynaptic modulation of neurotransmission. Section two is devoted to the molecular pharmacology of presynaptic receptors, whilst section three covers recent progress on the purification and molecular biology of transporter systems.
For pharmacologists, neurobiologists, biochemists, medicinal chemists and physicians.