Presynaptic Receptors and Neuronal Transporters

Edited by

  • S.Z. Langer
  • A.M. Galzin, Synthelabo-Recherche (LERS), Paris, France
  • J. Costentin, University of Rouen, St. Etienne du Rourray, France

The role of neuronal transporters in the inactivation of monoamine neurotransmitters and GABA following their release from nerve terminals has been established for at least 30 years. It is, however, during the past 10 years that receptor binding techniques have been used to label with high affinity the sodium-dependent transporter for serotonin and subsequently, that of other monoamine transmitters. This volume reviews the considerable advances in the field made since the first International Symposium on Presynaptic Receptors, and provides new insights into the function of presynaptic and neuronal transporters both in the periphery and in the CNS, with their ubiquitous locations and physiological roles. The first section deals with the extensive and still increasing list of presynaptic release-modulating auto- and heteroreceptors, and the different articles represent the current state of the art in the field of presynaptic modulation of neurotransmission. Section two is devoted to the molecular pharmacology of presynaptic receptors, whilst section three covers recent progress on the purification and molecular biology of transporter systems.
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For pharmacologists, neurobiologists, biochemists, medicinal chemists and physicians.


Book information

  • Published: January 1992
  • Imprint: PERGAMON
  • ISBN: 978-0-08-041165-1

Table of Contents

Selected Chapters: Preface. Physiological and pharmacological relevance of presynaptic receptors in neurotransmission, S Z Langer et al. Cholinergic-adrenergic presynaptic interactions in the heart and characterization of the receptors involved, E Muscholl et al. Effect of alpha-2 adrenoceptor antagonists on norephine release and inhibition of insulin secretion during pancreatic nerve stimulation. Interactions at pre- and postsynaptic sites, N Duval et al. In vivo presynaptic interaction between 5-HT and adrenergic antagonists on noradrenergic neurotransmission, M Davy et al. Factors influencing the function of presynaptic alpha-2 adrenoreceptors in rat brain, P J Hollingsworth & C B Smith. Terminal dopaminergic autoreceptors are of minor importance for the sedation produced by DA receptor agonists in rats, S Ahlenius et al. Autoreceptors and heteroreceptors evidenced by histamine H3 receptor ligands, M Garbarg et al. Autoreceptor-mediated control of serotonin release in the rat brain in vivo, B Scatton et al. A comparison of presynaptic serotonin autoreceptors in rabbit, rat and guinea-pig brain cortex, R Deicher et al. Modulation of dopamine and acetylcholine release in the rabbit caudate nucleus by opoids; receptor type and interaction with autoreceptors, R Jackisch et al. Localization of dopamine uptake complex by BTCP on rat brain sections and dopaminergic neurons in vitro, C Cerruti et al. Influence of the oxygen disponibility on the efficiency of the neuronal dopamine uptake complex, B Naudin et al. Pinoline, the natural ligand of serotonin transporter in retina and pineal gland, M M Airaksine