Preneoplasia of the Breast

A New Conceptual Approach to Proliferative Breast Disease


  • Werner Boecker, Prof Dr, Gerhard Domagk Institute for Pathology, University of Munster, Germany

PRENOEOPLASIA OF THE BREAST covers the clinical, radiological and histological diagnosis of benign proliferative breast disease and precursor lesions of breast cancer. It focuses on a new immunohistochemical method based on an innovative progenitor cell concept of breast epithelium that has been developed by Prof. Boecker, Prof. Schnitt and Prof. Silverstein. This technique can also be used for small samples (percutaneous core biopsy) and offers high specificity, and therefore provides a greater degree of diagnostic security. The practical applicability and interpretation of the technique are integrated into a comprehensive description of all benign and malignant noninvasive proliferative diseases of the breast, including: * Interpretation of histologic samples attained by stereotactic biopsy (including immunohistochemistry) * Comparison of radiologic and pathologic * Action to be taken in the case of in-situ malignoma * Treatment of DICS
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Book information

  • Published: August 2006
  • Imprint: SAUNDERS
  • ISBN: 978-0-7020-2892-2

Table of Contents

Chapter 1: Normal breast

Chapter 2: Fibrocystic change and miscellaneous "non-neoplastic" epithelial and stromal lesion

Chapter 3: Metaplastic changes and their neoplastic counterparts

Chapter 4: Percutaneous breast biopsy

Chapter 5: Non-operative breast pathology

Chapter 6: Examination of surgical specimens

Chapter 7: Basic principles of benign proliferative breast disease

Chapter 8: Usual ductal hyperplasia

Chapter 9: Sclerosing adenosis and other forms of adenosis

Chapter 10: Radial scar

Chapter 11: Papilloma

Chapter 12: Tubular adenoma and variants

Chapter 13: Adenoma of the nipple

Chapter 14: Adenomyoepithelial tumors

Chapter 15: Fibroadenoma and phyllodes tumor

Chapter 16: Inflammatory conditions of the breast

Chapter 17: Basic principles of precursor lesions of breast cancer

Chapter 18: Flat epithelial atypia

Chapter 19: Atypical ductal hyperplasia

Chapter 20: Ductal carcinoma in situ

Chapter 21: Lobular neoplasia

Chapter 22: The cytology of preneoplastic disease

Chapter 23: Hormonal and genetic risk factors

Chapter 24: Treatment for patients with ductal carcinoma in situ

Chapter 25: Risk adapted therapy of ductal carcinoma in situ

Chapter 26: Molecular concept of breast carcinogenesis

Chapter 27: EGF receptors in breast tumors