Practical Process Research and Development A guide for Organic ChemistsBy
- Neal Anderson, Neal G. Anderson, Anderson's Process Solutions LLC, Jacksonville, Oregon, USA
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry."
Second Edition highlights:
Reflects the current thinking in chemical process R&D for small molecules
Retains similar structure and orientation to the first edition.
Contains approx. 85% new material
Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)
Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)
Replaces the first edition, although the first edition contains useful older examples that readers may refer to
Hardbound, 488 Pages
Published: April 2012
Imprint: Academic Press
"This second edition text is at a more advanced level than the original, reflecting the abundant sources of information that have become available in the last ten years and the authors reconsideration of this presentation. Anderson has worked for 30-plus years in the pharmaceutical industry. His text offers a step-by-step approach, beginning with discussion of how and why operations are carried out and then illustrating principles with examples. Coverage encompasses process safety; route, reagent, and solvent selection; effect of water; in-process assays, controls, and specifications; practical considerations for scale-up; refining the process for simplicity and ruggedness; and troubleshooting, among other topics."--Reference and Research Book News, August 2012, page 265 "I would hope that most readers of this journal are very familiar with the first edition of Neal Andersons excellent book on Chemical Process Research and Development and are as keen to see the second edition as I was. The good news is that the new edition is bigger (by over 100 pages), better than the original, and cheaper The big improvement in the new edition is the layout so that the schemes are now much closer to the relevant text than before which makes reading that much easier Overall this book is highly recommended even if you already have a copy of the original edition."--Organic Process Research & Development
Chapter 1. Introduction to the role of process development
Chapter 2. Process Safety
Chapter 3. Route selectionChapter 4. Reagent selection
Chapter 5. Solvent selectionChapter 6. Effects of water
Chapter 7. In-Process Assays, In-Process Controls, and SpecificationsChapter 8. Practical Considerations for Scale-Up
Chapter 9. Optimizing by Minimizing ImpuritiesChapter 10. Optimizing Organometallic Reactions
Chapter 11. WorkupChapter 12. Crystallization and Purification
Chapter 13. Final Product Form and ImpuritiesChapter 14. Continuous Operations
Chapter 15. Refining the Process for Simplicity and RuggednessChapter 16. Process Implementation and Validation
Chapter 17. Trouble-shootingIndices: reagent type, reaction type, and general index including abbreviations.