Practical Biostatistics book cover

Practical Biostatistics

A Friendly Step-by-Step Approach for Evidence-based Medicine

Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. Practical Biostatistics provides researchers, medical professionals, and students with a friendly, practical guide to biostatistics. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials.

Audience

Investigators and clinicians involved in genetics, genomics, immunology, virology, microbiology, cell biology, pharmacology, and biomedical research; post-doctoral fellows and graduate researchers; physicians who need to make evidence-based clinical decisions; physicians and medical students who consult medical literature which demands knowledge on biostatistics; instructors and trainees in national and international technical clinician and degree programs

Paperback, 248 Pages

Published: July 2012

Imprint: Academic Press

ISBN: 978-0-12-415794-1

Reviews

  • "With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials."--Doody.com, April 24, 2013
    "Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics."

    Mauri Carakushansky, MD
    Pediatric Endocrinologist - Nemours Children's Clinic Orlando
    , Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida

    "This work by Dr. Suchmacher and Dr. Geller is bound to become a classic and should be readily available on the desk, shelf and on line."

    Salin Dahlben, Harvard University, Clinical Assistant Professor in Psychiatry, Tufts University

    "Dr. Suchmacher and Dr. Geller are experienced researchers and writers in the clinical research field, who were able to fathom the often confusing realm of Statistics applied to biological sciences, and to come back with a pragmatic study proposal for interested medical students and healthcare professionals […] In my opinion, 'Practical Biostatistics' will undoubtedly be welcomed as one of the books designed to bring medical students and healthcare professionals alike, closer to a better understanding of this inescapable issue."

    Spyros G.E. Mezitis, Assistant Professor of Clinical Medicine, The New York Presbyterian Hospital Weill, Cornell Medical Center

    "I believe the result of [Drs. Suchmacher and Geller’s] efforts will prove useful for many medical students and researchers, who must thrive in an era when Biostatistics is destined to be an ever present matter."

    Allan E. Rubenstein, Clinical Professor of Neurology, The Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, Langone Medical Center, School of Medicine, New York University

    Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics."

    Mauri Carakushansky, MD, Pediatric Endocrinologist - Nemours Children's Clinic Orlando, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida


Contents

  • PART 1 - STUDY TYPE DETERMINATION
    1. Epidemiological studies
    2. Analytical studies
    3. Summary


    PART 2 - OBSERVATIONAL STUDIES
    4. Determination of association strength between an exposure factor and an event in observational studies
    5. Increasing accuracy in observational studies


    PART 3 - STEP-BY-STEP BIOSTATISTICS OF A CLINICAL TRIAL
    6. STEP 1: Investigator's hypothesis and expression of its corresponding outcome
    7. STEP 2: n estimation and n assessment of a published trial
    8. STEP 3: Organization of variables and endpoints
    9. STEP 4: Measures for results expression of a clinical trial
    10. STEP 5: Determination of normality or non-normality of data distribution
    11. STEP 6: Hypothesis testing
    12. STEP 7: Correlating sample data with the general population - 95% confidence Interval


    PART 4 - ADDITIONAL CONCEPTS IN BIOSTATISTICS
    13. Individual and collective benefit and risk indexes inferable from intervention cohort studies
    14. Statistical assessment of diagnostic tests for the clinic
    15. Systematic reviews and meta-analyses
    16. Correlation and regression
    17. Per protocol analysis and intention to treat analysis


    Self-evaluation
    Annotated answers
    Microsoft Excel 2010 Basics
    References
    Glossary
    Index

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