Post-Genomic Cardiology

By

  • José Marín-García, Director, The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach.

This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA.

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Book information

  • Published: June 2014
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-404599-6

Reviews

"This Second edition of Post-Genomic Cardiology (PCG) deals with what promises to be the cardiology of the future. As the role of genetic screening in cardiology is strengthened, and as research on the multiple signaling pathways involved in cardiac organogenesis and pathology progresses, this 2nd edition of PCG further attempts to integrate known facts with what is still developing and with what is slowly becoming known. New areas of interest to cardiologists and researchers include systems biology, the constructive cycle of computational model building, and experimental verification. These are capable of providing the input necessary for exciting new discoveries, including the management of diseases in a “personalized” way. The book is fascinating because it introduces a field that no one with a minimum amount of scientific interest will be able to avoid in the very near future. Extensively referenced, and thoroughly researched, this book presents well-written and organized chapters, each with a summary of the important points discussed, followed by exhaustive bibliographies. A detailed glossary clearly defines the many acronyms used throughout the book. Unquestionably, this volume will be of great interest and use to clinical and research cardiologists, pharmacologists and genetics investigators; and to students of basic sciences. Dr. Marin-Garcia - author and editor of this 2nd edition of PGC has done an outstanding job of completing this challenging task." - Dr. Daniel Shindler

"This is a great book." - Dr. A. Bayes de Luna




Table of Contents

Preface
Section I: BIOCHEMICAL, CELLULAR AND MOLECULAR FUNCTIONING OF THE HEART
1. Introduction to Post-Genomic Cardiology
2. Molecular and Biochemical Methodology in the Post-Genomic Era
3. Cardiovascular Gene Expression. New advances
4. Cellular Techniques. New advances
5. Signaling Pathways
Section II: PEDIATRIC CARDIOLOGY IN THE POST-GENOMIC ERA
6. Cardiac Development: Molecular and Genetic Analysis
7. Inherited and Adquired Heart Disease
Section III: POST-GENOMIC ANALYSIS OF CORONARY ARTERY DISEASE, ANGIOGENESIS AND HYPERTENSION
8. Molecular Basis of Lipoproteins Disorders, Atherogenesis and Thrombosis
9. Ischemia and Myocardial Infarction: A Post-Genomic Appraisal
10.Cellular Pathways and Molecular Events in Cardioprotection
11. Cardiac Neovascularization: Angiogenesis, Arteriogenesis and Vasculogenesis
12. Systemic and Pulmonary Hypertension
Section IV POSTGENOMIC ANALYSIS OF THE MYOCARDIUM
13. Cardiomyopathies
14. Heart Response to Inflammation and Infection
Section V THE FAILING HEART
15. Molecular analysis of heart failure and remodeling.
16. Cardiac oxidative stress and cell death in the failing heart (new)
17. Mitochondrial dynamics in heart failure (new)
Section VI MOLECULAR AND GENETIC ANALYSIS OF METABOLIC DISORDERS
18. Fatty Acid and Glucose Metabolism in Cardiac Disease
Section VII MOLECULAR GENETIC OF DYSRHYTHMIAS
19. Dysrhythmias and Sudden Death
Section VIII GENES, GENDER AND ENVIRONMENT
20. Gender and Cardiovascular Disease
Section IX AGING AND THE CARDIOVASCULAR SYSTEM
21. The Aging Heart: Current Post-Genomic Appraisal
Section X. Current/New approaches to treatment
22. Genetic and epigenetic therapy of CVDs (new)
23. Cell transplantation in the broken heart (new)
Section XI -LOOKING TO THE FUTURE
23. New and Future trends in Post-Genomic Cardiology. Personalized medicine (new).
Section XII
GLOSSARY
INDEX