Platelets book cover


Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.

Hematologists, cardiologists, blood bankers, stroke physicians, pathologists, researchers in thrombosis and hemostasis, and students and fellows working in these fields

Hardbound, 1398 Pages

Published: December 2012

Imprint: Academic Press

ISBN: 978-0-12-387837-3


  • Reviews of the Third Edition

    "Comprehensive and definitive, this third-edition reference integrates platelet biology, pathophysiology, and clinical medicine. Sixty-four chapters address biology, function, disease, disorders of platelet number or function, antiplatelet therapy, and therapy to increase numbers and/or function."
    - Reference and Research Book News, August 2013

    "I've been reading various chapters for the past few days and have been marveling at the sheer depth and breadth. No other textbook or other reference source is comparable…You must have this book if your practice or interest even superficially touches on platelets."
    -, June 21, 2013

    "Platelets is the definitive current source of state- of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine."
    -, April 24, 2013

    "One might well question the value of a doorstopper-sized textbook in this era of instant Internet access to all variety of even the most arcane information. A notable exception, however, is the third edition of Michelson’s Platelets. The surprising complexity of these anucleate cells and their diverse and ever enlarging roles in physiology and disease has attracted a large cadre of interdisciplinary researchers focused on various aspects of these roles. Having at ready hand a readable, authoritative, comprehensive and beautifully illustrated and cross-referenced volume makes for easy access to important information required by these researchers - both established senior investigators and their students."
    - Thomas P Stossel, MD, American Cancer Society Professor of Medicine Harvard Medical School Director, Translational Medicine Unit and center for Medical Innovation Senior Physician, Hematology Division Brigham & Women's Hospital, Boston, MA, USA

    Reviews of the Second Edition

    "...the book is a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells."
    - Journal of the American Medical Association

    "This is a fantastic resource for anyone who treats patients with platelets disorders or is engaged in platelet or megakaryocyte-based research."
    - British Journal of Haematology

    "This is the second edition of a comprehensive book on everything you could ever possibly want to know about platelets...The purpose is to provide a comprehensive, definitive, and authoritative book on platelets. These are worthy objectives, well met in this updated edition...This book would interest anyone wanting to learn about platelets: physicians at all stages of training or practice, clinical laboratory scientists at any stage of training or practice, and basic scientists interested in learning about clinical aspects of platelets...This is the book I'll use whenever I have to answer any type of platelet question. If you field platelet questions, you should get this book, too."
    - Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars)


  • Foreword
    A Brief History of Ideas About Platelets in Health and Disease / Barry S. Coller

    Part One: Platelet Biology
    1. The Evolution of Mammalian Platelets / Jack Levin
    2. Megakaryocyte Development and Platelet Formation / Joseph E. Italiano Jr.
    3. The regulation of platelet life span / Benjamin T. Kile
    4. Platelet Genomics / Willem Ouwehand, Paul F. Bray
    5. Platelet MicroRNAs / Patrick Provost
    6. The Platelet Proteome / Andrew S. Weyrich
    7. Platelet Structure / James G. White
    8. The Platelet Cytoskeleton / John H. Hartwig
    9. Platelet Receptors / Kenneth J. Clemetson
    10. The GPIb-IX-V Complex / Michael C. Berndt
    11. GPVI and CLEC-2 / Steve P. Watson, Alice Y. Pollitt, Craig E. Hughes
    12. Integrin AlphaIIb Beta3 / Edward F. Plow
    13. Protease-activated Receptors / Athan Kuliopulos, Ping Zhang, Lidija Covic
    14. The Platelet P2 Receptors / Marco Cattaneo
    15. PECAM-1 / Peter J. Newman, Debra Newman
    16. Interactions Between Platelets, Leukocytes and the Endothelium / Susan S. Smyth
    17. Inhibition of Platelet Function by the Endothelium / Jane E. Freedman
    18. Platelet Secretion / Robert Flaumenhaft
    19. Signal Transduction During Platelet Plug Formation / Lawrence F. Brass
    20. Platelet Thrombus Formation in Flowing Blood / Zaverio M. Ruggeri
    21. Interactions Between Platelets and the Coagulation System / Paula B. Tracy
    22. Platelet-Derived Microparticles / Rienk Nieuwland
    23. The Role of Platelets in Fibrinolysis / Nicola J. Mutch
    24. The Role of Platelets in Angiogenesis / Giannoula Lakka Klement, Ela Shai, David Varon
    25. Platelet Function in the Newborn / Sara J. Israels

    Part Two: Tests of Platelet Function
    26. Clinical Tests of Platelet Function / Paul Harrison
    27. Platelet Counting / Paul Harrison
    28. Platelet Aggregation / Catherine Pauline Hayward, Karen A. Moffat
    29. Flow Cytometry / Alan D. Michelson
    30. Monitoring of Antiplatelet Therapy / Paul A. Gurbel, Udaya S. Tantry
    31. Real Time In Vivo Imaging of Platelets During Thrombus Formation / Bruce Furie, Barbara Furie

    Part Three: The Role of Platelets in Disease
    32. Atherothrombosis and Coronary Artery Disease / Meinrad Gawaz
    33. Central Nervous System Ischemia / Gregory J. del Zoppo
    34. Peripheral Vascular Disease / Michael Sobel
    35. Diabetes Mellitus / Giovanni Davi
    36. Inflammation / Guy Zimmerman
    37. Antimicrobial Host Defense / Michael R. Yeaman, Arnold Bayer
    38. Tumor Growth and Metastasis / Jerry Ware

    Part Four: Disorders of Platelet Number and Function
    39. The Clinical Approach to Disorders of Platelet Number and Function / Alan D. Michelson
    40. Immune Thrombocytopenia (ITP) / James B. Bussel, Bethan Psaila
    41. Drug-induced Thrombocytopenia / Richard H. Aster
    42. Heparin-induced Thrombocytopenia / Andreas Greinacher, Theodore Warkentin, Beng H. Chong
    43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome / Han-Mou Tsai
    44. Thrombocytopenia in Pregnancy / Keith R. McCrae
    45. Thrombocytopenia in the Newborn / Irene A.G. Roberts
    46. Alloimmune Thrombocytopenia / Cecile Kaplan, Heyu Ni, John Freedman
    47. Inherited Thrombocytopenias / Mortimer Poncz, Michele P. Lambert and Ravichandran Mohan
    48. Pseudothrombocytopenia / Nicola Bizzaro
    49. Thrombocytosis and Essential Thrombocythemia / Ayalew Tefferi
    50. Congenital Disorders of Platelet Function / Marco Cattaneo
    51. Acquired Disorders of Platelet Function / A. Koneti Rao
    52. Cardiopulmonary Bypass / Brian Richard Smith, Henry M. Rinder, Christine S. Rinder

    Part Five: Antiplatelet Therapy
    53. Aspirin / Carlo Patrono
    54. ADP Receptor Antagonists / Marco Cattaneo
    55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists / Anthony A. Bavry
    56. Dipyridamole / Wolfgang G. Eisert
    57. Cilostazol / Yasuo Ikeda, Toshiki Sudo
    58. Novel Antiplatelet Therapies / Deepak L. Bhatt

    Part Six: Therapy to Increase Platelet Numbers and/or Function
    59. Thrombopoietin Mimetics / David J. Kuter
    60. Desmopressin / Pier Mannuccio Mannucci
    61. Factor VIIa / Man-Chiu Poon
    62. Platelet Transfusion Medicine / Peter L. Perrotta, Jeremy Parsons, Henry M. Rinder, Edward L. Snyder
    63. Making Platelets Ex Vivo / Mortimer Poncz, Spencer Sullivan, Michele P. Lambert
    64. Gene Therapy for Platelet Disorders / David A. Wilcox


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