Edited by

  • Alan Michelson, Harvard University Medical School, Boston, MA, USA


  • Alan Michelson, Harvard University Medical School, Boston, MA, USA

PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.
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Hematologists, cardiologists, blood bankers, stroke physicians, pathologists, researchers in thrombosis and hemostasis, and students and fellows working in these fields


Book information

  • Published: October 2006
  • ISBN: 978-0-12-369367-9


"This is the second edition of a comprehensive book on everything you could ever possibly want to know about platelets...The purpose is to provide a comprehensive, definitive, and authoritative book on platelets. These are worthy objectives, well met in this updated edition...This book would interest anyone wanting to learn about platelets: physicians at all stages of training or practice, clinical laboratory scientists at any stage of training or practice, and basic scientists interested in learning about clinical aspects of platelets...This is the book I'll use whenever I have to answer any type of platelet question. If you field platelet questions, you should get this book, too." - Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital, FOR DOODY'S (4 Stars) "...the book is a clearly written, concise, and comprehensive discussion of platelets and their disorders that will be useful to anyone whose professional activity involves these important little cells." -Michael J. Domanski, MD, National Heart Lung and Blood Institute, in JAMA "This is a fantastic resource for anyone who treats patients with platelets disorders or is engaged in platelet or megakaryocyte-based research." - BRITISH JOURNAL OF HAEMATOLOGY

Table of Contents

ForewordA Brief History of Ideas About Platelets in Health and Disease. Barry S. CollerPart One: Platelet Biology1. The Evolution of Mammalian Platelets. Jack Levin2. Megakaryocyte Development and Platelet Formation. Joseph E. Italiano, Jr., John H. Hartwig3. Platelet Structure. James G. White4. The Platelet Cytoskeleton. John H. Hartwig5. Platelet Genomics and Proteomics. Ángel García, Yotis Senis, Michael G. Tomlinson, Steve P. Watson6. Platelet Receptors. Kenneth J. Clemetson, Jeannine M. Clemetson7. The Glycoprotein Ib-IX-V Complex. Robert K. Andrews, Michael C. Berndt, José A. López 8. Integrin αIIbβ3. Edward F. Plow, Michelle Pesho, Yan-Qing Ma 9. Thrombin Receptors. Wadie F. Bahou10. The Platelet P2 Receptors. Marco Cattaneo11. PECAM-1. Melanie S. Novinska, Vipul Rathore, Debra K. Newman, Peter J. Newman12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium. Rodger P. McEver13. Inhibition of Platelet Function by the Endothelium. Sybille Rex, Jane E. Freedman14. Platelet Polymorphisms. Vahid Afshar-Kharghan, K. Vinod Vijayan, Paul F. Bray15. Platelet Secretion. Guy L. Reed16. Signal Transduction During the Platelet Plug Formation. Lawrence F. Brass, Timothy J. Stalker, Li Zhu, Donna S. Woulfe17. Outside-in Signaling By Integrin αIIbβ3. Nicolas Prévost, Sanford J. Shattil18. Platelet Thrombus Formation in Flowing Blood. Brian Savage, Zaverio M. Ruggeri19. Interactions Between Platelets and the Coagulation System. Beth A. Bouchard, Saulius Butenas, Kenneth G. Mann, Paula B. Tracy20. Platelet-Derived Microparticles. Rienk Nieuwland, Augueste Sturk21. The Role of Platelets in Fibrinolysis. Bradley A. Maron, Joseph Loscalzo22. Platelet Function in the Newborn. Sara J. IsraelsPart Two: Tests of Platelet Function23. Clinical Tests of Platelet Function. Paul Harrison, David Keeling24. Platelet Counting. Carol Briggs, Paul Harrison, Samuel J. Machin 25. The Bleeding Time. Stuart E. Lind, Carla D. Kurkjian26. Platelet Aggregation. Lisa K. Jennings, Melanie McCabe White27. The VerifyNow System. Steven R. Steinhubl28. Platelet Function Analyzer (PFA)-100. John L. Francis29. Impact Cone and Plate(let) Analyzer. David Varon, Naphtali Savion30. Flow Cytometry. Alan D. Michelson, Matthew D. Linden, Marc R. Barnard, Mark. I. Furman, A.L. Frelinger III31. Thromboxane Generation. Tilo Grosser, Susanne Fries, Garret A. FitzGerald 32. Perfusion Chambers. Philip G. de Groot, Jan J. Sixma33. Animal Models. David H. Lee, Morris A. Blajchman34. Real Time In Vivo Imaging of Platelets During Thrombus Formation. Christophe Dubois, Ben Atkinson, Barbara Furie, Bruce FuriePart Three: The Role of Platelets in Disease35. Atherothrombosis and Coronary Artery Disease. Pascal J. Goldschmidt, Neuza Lopes, Lawrence E. Crawford, Richard C. Becker36. Central Nervous System Ischemia. Gregory J. del Zoppo37. Peripheral Vascular Disease. Michael Sobel38. Diabetes Mellitus. Bernd Stratmann, Barbara Menart, Diethelm Tschoepe 39. Inflammation. Wolfgang Bergmeier, Denisa D. Wagner40. Antimicrobial Host Defense. Michael R. Yeaman, Arnold S. Bayer41. Angiogenesis. Alexander Brill, David Varon42. Tumor Growth and Metastasis. Mary Lynn Nierodzik, Simon Karpatkin43. Alzheimer’s Disease. Qiao-Xin Li, Colin L. Masters44. Psychiatric Disorders. George N. M. GurguisPart Four: Disorders of Platelet Number and Function45. The Clinical Approach to Disorders of Platelet Number and Function. Alan D. Michelson46. Immune Thrombocytopenic Purpura. James B. Bussel47. HIV-1-related Thrombocytopenia. Michael A. Nardi, Zongdong Li, Simon Karpatkin48. Heparin-induced Thrombocytopenia. Beng H. Chong49. Drug-induced Thrombocytopenia. Richard H. Aster50. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome. Joel L. Moake51. Thrombocytopenia in Pregnancy. Keith R. McCrae52. Thrombocytopenia in the Newborn. Irene A. G. Roberts, Neil A. Murray53. Alloimmune Thrombocytopenia. Cecile Kaplan, John Freedman54. Inherited Thrombocytopenias. Michele P. Lambert, Mortimer Poncz55. Pseudothrombocytopenia. Nicola Bizzaro56. Thrombocytosis and Essential Thrombocythemia. Ayalew Tefferi57. Inherited Disorders of Platelet Function. Alan T. Nurden, Paquita Nurden58. Acquired Disorders of Platelet Function. A. Koneti Rao59. Cardiopulmonary Bypass. Brian Richard Smith, Henry M. Rinder, Christine S. RinderPart Five: Pharmacology: Antiplatelet Therapy60. Aspirin. Eric H. Awtry, Joseph Loscalzo61. ADP Receptor Antagonists. Marco Cattaneo62. αIIbβ3 (GPIIb-IIIa) Antagonists. Ramtin Agah, Edward F. Plow, Eric J. Topol63. Dipyridamole. Wolfgang G. Eisert64. Cilostazol. Yasuo Ikeda, Toshiki Sudo, Yukio Kimura65. Experimental Antiplatelet Therapy. Anthony A. Bavry, Deepak L. Bhatt, Eric J. TopolPart Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function66. Platelet Growth Factors. David J. Kuter67. Desmopressin (DDAVP). Pier Mannuccio Mannucci, Marco Cattaneo68. Factor VIIa. Man-Chiu PoonPart Seven: Platelet Transfusion Medicine69. Platelet Storage and Transfusion. Peter L. Perrotta, Edward L. Snyder70. Platelet Substitutes and Novel Methods of Platelet Preservation. David H. Lee, Morris A. BlajchmanPart Eight: Gene Therapy for Platelet Disorders71. Gene Therapy for Platelet Disorders. David A. Wilcox, Gilbert C. White II