Plasticity in the Adult Brain: From Genes to Neurotherapy book cover

Plasticity in the Adult Brain: From Genes to Neurotherapy

In the past decade neuronal plasticity has become a major theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in worms and insects to behavioural recovery from strokes in elderly humans. For this reason the focus of interest in the present volume of Progress in Brain Research is on the topic of neuroplasticity in mature organisms, including humans. Contributions range from neurogenesis and synaptic plasticity in the adult primate brain, to neural mechanisms of learning and memory, and the influence of environmental factors and aging on the functional potential of the central nervous system. Several contributions focus on recent developments in neural regeneration and brain repair, providing challenging evidence that the use of stem cell neurotherapy may be beneficial to humans suffering from various neurological and psychiatric diseases. This volume integrates new information on the cellular and molecular mechanisms of neuroplasticity and highlights challenging future questions in this exciting and topical area of neuroscience.

Included in series
Progress in Brain Research

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Published: October 2002

Imprint: Elsevier

ISBN: 978-0-444-50981-9

Contents

  • List of contributors. Preface. Acknowledgements. Section I. Neurogenesis in Adulthood: New Neurons in Old Brains. 1. Neurogenesis in adult primates (P. Rakic). Section II. Brain Plasticity: From Molecule to Neural Network. 2. Semaphorins: contributors to structural stability of hippocampal networks?(A.J.G.D. Holtmaat et al.). 3. Neurotrophins and visual cortical plasticity (A.D. Huberman, A.K. McAllister). 4. Dendritic spines: elementary structural units of neuronal plasticity (M. Segal). 5. Abnormal plastic changes in a rat model for mesial temporal lobe epilepsy: a short review(J.A. Gorter, F.H. Lopes Da Silva). 6. Cortical map plasticity in animals and humans (J.P. Rauschecker). Section III. Learning and Memory. 7. A brain adaptation view of plasticity: is synaptic plasticity an overly limited concept? (A.W. Grossman et al.). 8. Environmental enrichment and the brain(A.H. Mohammed et al.). 9. Sex hormones, neuroprotection and cognition (C. Behl). 10. Memory reactivation and consolidation during sleep: from cellular mechanisms to human performance (C.M.A. Pennartz et al.). 11. Sensory loss and cortical reorganization in mature primates (J.H. Kaas). 12. Human brain plasticity: evidence from sensory deprivation and altered language experience (H. Neville, D. Bavelier). Section IV. Circadian and Seasonal Plasticity. 13. Modes of plasticity within the mammalian circadian system (S. Amir et al.). 14. Functional plasticity of the circadian timing system in old age: light exposure (E.J.W. Van Someren et al.). 15. What is the adaptive role of neurogenesis in adult birds? (M. Gahr et al.). 16. A brain for all seasons: cellular and molecular mechanisms of photoperiodic plasticity(M.A. Hofman, D.F. Swaab). Section V. Neural Plasticity in Aging and Neuropathology. 17. Regulation of synaptic plasticity in memory and memory decline with aging(T.C. Foster). 18. Synaptic plasticity in the diabetic brain: advanced aging? (A. Artola et al.). 19. Adult neurogenesis: implications for psychiatry (A.J. Eisch). 20. Brain aging and Alzheimer's disease - use it or lose it(D.F. Swaab et al.). 21. Functional genomics and psychiatric illness (W. Hasenkamp, S.E. Hemby). Section VI. Cell Implantation and Gene Therapy. 22. The fifteenth C.U. Ariëns Kappers lecture (an introduction) (D.F. Swaab, M.A. Hofman). 23. New strategies in neural repair (M.H. Tuszynski et al.). 24. Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease (L.M. Björklund, O. Isacson). 25. Neuroprotection for Parkinson's disease using viral vector-mediated delivery of GDNF (J.L. McBride, J.H. Kordower). Section VII. Stem Cells: Their Role in Brain Repair. 26. Glial stem-like cells: implications for ontogeny, phylogeny and CNS regeneration (E.D. Laywell, D.A. Steindler). 27. Induced neurogenesis by endogenous progenitor cells in the adult mammalian brain (E. Chmielnicki, S.A. Goldman). 28. The use of human embryonic stem cells for research: an ethical evaluation (G. De Wert). Subject Index.

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