Photodynamic Therapy and Fluorescence Diagnosis in Dermatology

Edited by

  • P. Calzavara-Pinton, Department of Dermatology, Azienda Spedali Civili di Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
  • R-M. Szeimies, Department of Dermatology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany
  • B. Ortel, Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital/Harvard Medical School, 55 Fruit Street, Boston MA02114, USA

Photodynamic therapy has been widely investigated over the past two decades and is emerging as a promising therapeutic modality for skin cancers and several inflammatory diseases. This growing interest is based on the availability of a new simple, effective and safe regimen using the topical application of a pro-drug, 5-aminolevulinic acid, as well as on the development of new "second generation" photosensitizers, namely 5-aminolevulinic acid-esters, phthalocyanines, chlorins, porphycenes and hypericin. In contrast to hematoporphyrin derivatives, these compounds are characterized by short-lasting generalized skin photosensitivity. These dyes are available for either topical or systemic delivery and are well characterized. The basic principles of PDT is more complex than chemotherapy or other pharmacological modalities. PDT involves not only a drug but an otherwise harmless compound that is activated by visible light. The interaction of these two treatment components is PDT. The variability of these both components results in a complexity of the treatment that may disorient the clinician who does not have specific experience in this field. This book aims to focus experimental and clinical findings on PDT in order to attract and direct the attention of a growing number of dermatologists.
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For dermatologists, oncologists, biochemists, photochemists and photobiologists in academic and industrial research.


Book information

  • Published: August 2001
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-50828-7

Table of Contents

Part I: History and Basics.History of photodynamic therapy in dermatology(R.-M. Szeimies et al.). Primary processes in photosensitization mechanisms(B.M. Aveline).Mechanism of action - molecular effects(A.C.E. Moor, B. Ortel).Correlation of intracellular and intratumoral photosensitizer distribution with photodynamic effect(Q. Peng).Immunologic actions of PDT(D.W.C. Hunt et al.). Light sources for photodynamic therapy and fluorescence diagnosis in dermatology(W. Baumler).Part II: Photosensitizers.Photosensitizers - systemic sensitization(C. Zane et al.).Basic principles of 5-aminolevulinic acid-based photodynamic therapy(K. Berg).Part III: Photodynamic Diagnosis.Fluorescence diagnosis(C. Abels, G. Ackermann).Part IV: Systemic Photodynamic Therapy.Systemic sensitization - oncologic indications in dermatology(C. Abels, R.-M. Szeimies).Systemic sensitization - non-oncologic indications in dermatology(R. Bissonnette, H. Lui). Part V: Topical Photodynamic Therapy.Topical sensitization - oncologic indications - actinic keratoses(A. Sidoroff).Topical sensitization - oncologic indications - Bowen's disease(C.A. Morton).Photodynamic therapy of basal cell carcinoma(A.-M. Wennberg, O. Larko).Topical sensitization - oncologic indications - others (lymphoma)(R. Fink-Puches, P. Wolf).Topical photodynamic therapy for psoriasis(W.-H. Boehncke).Photodynamic therapy of pilosebaceous units(C.C. Dierickx).Topical sensitization - non-oncologic indications(C. Alge, R.-M. Szeimies).Topical sensitization - non-oncologic indications(S. Karrer).Part VI: Conclusive Remarks.Practical guidelines(P. Calzavara-Pinton). Cutaneous photosensitivity and photoprotection for photodynamic therapy patients(M. Trehan, C.R. Taylor).Future directions - photosensitizer targeting and new disease indications(M.R. Hamblin, B. Ortel).Keyword Index.