Pharmacology of 5-HT6 receptors, Part I

Edited by

  • Franco Borsini, Head, Central & Peripheral Nervous System and General Pharmacology Area - R&D Department, sigma-tau SpA, Pomezia (Rome), Italy

The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors.
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Audience

Neuroscientists, neurologists, psychologists, psychiatrists, pharmacologists

 

Book information

  • Published: November 2010
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-384976-2


Table of Contents

  1. 5-HT6 Medicinal Chemistry
  2. Kevin G. Liu and Albert J. Robichaud

  3. Patents
  4. Nicolas Vincent Ruiz and Gloria Oranias

  5. 5-HT6 Receptor Charactertization
  6. Teresa Riccioni

  7. 5-HT6 receptor signal transduction. Second Messenger Systems
  8. Xavier Codony, Javier Burgueño, Maria Javier Ramírez, José Miguel Vela

  9. Electrophysiology of 5-HT6 Receptors
  10. Annalisa Tassone, Graziella Madeo, Giuseppe Sciamanna, Antonio Pisani, and Paola Bonsi

  11. Genetic Variations and Association
  12. Massimo Gennarelli and Annamaria Cattaneo

  13. Pharmacokinetics of 5-HT6 Receptors Ligands

Angelo Mancinelli