Challenges and Opportunities in Therapeutic Implementation

Edited by

  • Yui-Wing Francis Lam, PharmD, Professor of Pharmacology, Department of Pharmacology and Associate Professor, Department of Medicine, The University of Texas Health Science Center at San Antonio
  • Larisa Cavallari, PharmD, Associate Professor, Department of Pharmacy Practice, University of Illinois at Chicago

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.
View full description


This book is intended for scientists and clinicians interested in pharmacogenomics implementation in academic, research, medical and pharmaceutical industry settings. Relevant fields include pharmacology, pharmaceutical sciences, genetics, molecular biology and medicine. This book may also be used as a recommended textbook for pharmacy students and graduate-level students in health and pharmaceutical science programs. 


Book information

  • Published: March 2013
  • ISBN: 978-0-12-391918-2


"...a practical and indispensable resource on both the opportunities and challenges that allows readers to reflect on the future direction of pharmacogenomics while applying these observations to their own work or research."--Anticancer Research, February 2015

"Lam and Cavallari bring together pharmacy and other specialists from North America, Europe, and Asia for 13 chapters aimed at scientists, clinicians, and students in health and pharmaceutical sciences. The chapters consider the translation of pharmacogenomic findings into therapeutic applications from academic, regulatory, pharmaceutical, clinical, socioethical, and economic perspectives."--Reference and Research Book News, August 2013
"This book succeeds in providing a relevant and unique perspective, by international experts in the field, on the progress and challenges facing the translation of pharmacogenomics into clinical practice. I highly recommended it to anyone with an interest in the topic, from the essential basics to its role in the future practice of medicine.", August 2, 2013

Table of Contents


1 Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications
2 Translating Pharmacogenomic Research to Therapeutic Potentials
3 Governmental and Academic Efforts to Advance the Field of Pharmacogenomics (PGRN CPIC, PharmGKB)

Section 2

4a Pharmacogenomics in Cancer Therapeutics
4b A Look to the Future:  Cancer epigenetics
5a Pharmacogenomics in Cardiovascular Diseases
5b A Look to the Future: Cardiovascular Pharmaco-epigenetics
6a Pharmacogenomics in Psychiatry Disorders
6b A Look to the Future: Epigenetics in psychiatric disorders and treatment
7 Role of Pharmacogenomics in Diabetes and Other Therapeutic Areas 


8a Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development
8b Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development
9a Incorporating Pharmacogenomics in Drug Development
Part 1:  Rational  study designs for pharmacogenetic research and therapy - A perspective  from academia
9b Incorporating Pharmacogenomics in Drug Development
Part 2:  A perspective from industry
10 Ethnobridging and Pharmacogenomics


11 Beyond ELSIs - Where to from here? From 'Regulator' to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine
12 The Economics of Pharmacogenomics


13 Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics is not enough