Contents. List of Contributors. Introduction to the Series. Preface (S. Gordon). Secton I Context. The early History of Phagocytosis (T.P. Stossel). Drosophila Hemocytes, Phagocytosis, and Croquemort, a Macrophage Receptor (N.C. Franc). Phagocytosis by Nonprofessional Phagocytes (D. Williams-Herman and Z. Werb). Section II Receptors. Scavenger Receptors and Phagocytosis of Bacteria and Apoptotic Cells (N. Platt, R. Haworth, R.P. da Silva, and S. Gordon). Mannose Receptor and Phagocytosis (I.P. Fraser, R. Alan and B. Ezekowitz). Integrin Receptors of Phagocytes (S.D. Blystone and E.J. Brown). Fc Receptor-Mediated Phagocytosis (S. Greenberg). Section III Signaling. Heterogeneity in Macrophage Phagocytosis (A. Aderem and D.M. Underhill). Signaling through RHO GTPases in Phagocytes (A.E. Abo). Regulatory Roles of Phosphatidylinositol (4,5) Bisphosphate in Cell Signalin, Membrane Traffic, and the Cytoskeleton (S. Cockcroft). Section IV The Pathway. Pathways through the Macrophage Vacuolar Compartment (J.A. Swanson). Sequential Maturation of Phagosomes provides unique Targets for Pathogens (C. Alvarez-Dominguez, L. Mayorga, and P.D. Stahl). Phagosomal Acidification: Mechanisms and Funtional Significance (D.J. Hackam, O.D. Rotstein, and S. Grinstein). The Phagocyte Actin Cytoskeleton (H. Sun, K. Lin, M. Yamamoto, and H.L. Yin). Section V Responses. Nramp1: A Novel Macrophage Protein with a Key Function in Resistance to Intracellular Pathogens (S. Gruenheid, E. Skamene, and P. Gros). Uptake and Presentation of Phagocytosed Antigens by Dendritic Cells (M.L. Albert, S. Turley, W. Garrett, I. Mellman, K. Inaba, N. Bhardway, and R.M. Steinman). Processing and Presentation of Phagocytosed Antigens to the Immune System (J. Pieters). Antimicrobial Mechanisms of Macrophages (M.U. Shiloh and C.F. Nathan). Components and Organization of the Nadph Oxidase of Phagocytic Cells: Its Role in Microbial Killing and in the Molecular Pathology of Chronic Granulomatous Disease (A.W. Segal, f. wientjes, R.W. Stockley, and L.V. Dekker). Oxygen-Independent Antimicrobial Mechanisms of PMN (P. Elsbach). Index.