Peripheral Nerve Disorders

Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

Edited by

  • Gérard Said, Médecin Consultant, Department of Neurology, Hôpital de la Salpétrière, Paris, France
  • Christian Krarup, Department of Clinical Neurophysiology, Rigshospitalet, Copenhagen, Denmark

Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities.
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Clinical neurologists and research neuroscientists


Book information

  • Published: September 2013
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-52902-2

Table of Contents

Section 1 Introduction

1. Prelude to the peripheral neuropathies  

Section 2 Structure and function

2. Microscopic anatomy: normal structures  

3. Gross anatomy and Development of the Peripheral Nervous System  

4. Physiology and pathophysiology of myelinated nerve fibers  

5. Biology of Schwann cells  

6. Neurophysiological approach to disorders of peripheral nerve  

7. Testing autonomic functions  

8. Imaging of the peripheral nervous system  

9. The nerve biopsy: indications, technical aspects and contribution  

10. The cutaneous nerve biopsy: Technical aspects, indications, and contribution  

11. Antibody testing in peripheral nerve disorders  

12. DNA testing in hereditary neuropathies  

Section 3 Clinical aspects

13. Examination and clinical care of the patient with neuropathy  

14. How to explore a patient with chronic axonal neuropathy  

15. Evaluation of a patient with suspected chronic demyelinating polyneuropathy  

16. Sensory-motor assessment in clinical research trials  

17. Management of painful neuropathies  

Section 4 Plexus and compression lesions

18. Diagnosis of brachial and lumbosacral plexus lesions  

19. Compression and entrapment neuropathies  

20. Facial nerve palsy and hemifacial spasm  

Section 5 Inflammatory root and nerve lesions

21. The Guillain-Barré syndrome  

22. Chronic inflammatory demyelinating polyneuropathy   

23. Treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)  

24. Multifocal motor neuropathy  

25. Neuropathy and monoclonal gammopathy  

Section 6 Neuropathy in connective tissue disorders

26. Vasculitic neuropathy  

27. Sarcoidosis of the peripheral nervous system  

Section 7 Neuropathy in infectious disorders

28. Leprous neuropathy  

29. HIV peripheral neuropathy  

30. Human t-cell leukemia virus (HTLV) associated neuropathy  

31. Herpes virus infection of the peripheral nervous system  

32. Lyme neuroborreliosis  

Section 8 Neuropathy and metabolic disorders

33. Diabetic neuropathy  

34. Biology of diabetic neuropathy  

35. Uremic neuropathy  

36. Porphyric neuropathy  

37. Fabry’s disease  

38. Transthyretin familial amyloid polyneuropathy  

39. Hereditary gelsolin amyloidosis  

Section 9 Neuropathy and malignancy

40. Malignant cell infiltration in the peripheral nervous system  

41. Paraneoplastic neuropathy  

Section 10 Cryptogenic, Traumatic and Iatrogenic neuropathies

42. Drug induced neuropathies  

43. Late radiation injury to peripheral nerves  

44. Neuromuscular complications of critical illness  

45. The surgery of peripheral nerves (including tumours)  

46. Neuropathy in the elderly  

Section 11 Familial neuropathies

47. Dominant Charcot-Marie-Tooth syndrome and cognate disorders  

48. Recessively transmitted predominantly motor neuropathies  

49. Early onset childhood monogenic neuropathies

50. Hereditary sensory and autonomic neuropathies

51. Peripheral nerve involvement in hereditary cerebellar and multisystem degenerative disorders

52. Giant axonal neuropathy  

53. Neurofibromatosis 1(NF1), diagnosis and management  

54. Neurofibromatosis type 2 (NF2) diagnosis and management