Peripheral Nerve Disorders book cover

Peripheral Nerve Disorders

Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities.

Clinical neurologists and research neuroscientists

Hardbound, 1008 Pages

Published: September 2013

Imprint: Elsevier

ISBN: 978-0-444-52902-2


  • Section 1 Introduction

    1. Prelude to the peripheral neuropathies  

    Section 2 Structure and function

    2. Microscopic anatomy: normal structures  

    3. Gross anatomy and Development of the Peripheral Nervous System  

    4. Physiology and pathophysiology of myelinated nerve fibers  

    5. Biology of Schwann cells  

    6. Neurophysiological approach to disorders of peripheral nerve  

    7. Testing autonomic functions  

    8. Imaging of the peripheral nervous system  

    9. The nerve biopsy: indications, technical aspects and contribution  

    10. The cutaneous nerve biopsy: Technical aspects, indications, and contribution  

    11. Antibody testing in peripheral nerve disorders  

    12. DNA testing in hereditary neuropathies  

    Section 3 Clinical aspects

    13. Examination and clinical care of the patient with neuropathy  

    14. How to explore a patient with chronic axonal neuropathy  

    15. Evaluation of a patient with suspected chronic demyelinating polyneuropathy  

    16. Sensory-motor assessment in clinical research trials  

    17. Management of painful neuropathies  

    Section 4 Plexus and compression lesions

    18. Diagnosis of brachial and lumbosacral plexus lesions  

    19. Compression and entrapment neuropathies  

    20. Facial nerve palsy and hemifacial spasm  

    Section 5 Inflammatory root and nerve lesions

    21. The Guillain-Barré syndrome  

    22. Chronic inflammatory demyelinating polyneuropathy   

    23. Treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)  

    24. Multifocal motor neuropathy  

    25. Neuropathy and monoclonal gammopathy  

    Section 6 Neuropathy in connective tissue disorders

    26. Vasculitic neuropathy  

    27. Sarcoidosis of the peripheral nervous system  

    Section 7 Neuropathy in infectious disorders

    28. Leprous neuropathy  

    29. HIV peripheral neuropathy  

    30. Human t-cell leukemia virus (HTLV) associated neuropathy  

    31. Herpes virus infection of the peripheral nervous system  

    32. Lyme neuroborreliosis  

    Section 8 Neuropathy and metabolic disorders

    33. Diabetic neuropathy  

    34. Biology of diabetic neuropathy  

    35. Uremic neuropathy  

    36. Porphyric neuropathy  

    37. Fabry’s disease  

    38. Transthyretin familial amyloid polyneuropathy  

    39. Hereditary gelsolin amyloidosis  

    Section 9 Neuropathy and malignancy

    40. Malignant cell infiltration in the peripheral nervous system  

    41. Paraneoplastic neuropathy  

    Section 10 Cryptogenic, Traumatic and Iatrogenic neuropathies

    42. Drug induced neuropathies  

    43. Late radiation injury to peripheral nerves  

    44. Neuromuscular complications of critical illness  

    45. The surgery of peripheral nerves (including tumours)  

    46. Neuropathy in the elderly  

    Section 11 Familial neuropathies

    47. Dominant Charcot-Marie-Tooth syndrome and cognate disorders  

    48. Recessively transmitted predominantly motor neuropathies  

    49. Early onset childhood monogenic neuropathies

    50. Hereditary sensory and autonomic neuropathies

    51. Peripheral nerve involvement in hereditary cerebellar and multisystem degenerative disorders

    52. Giant axonal neuropathy  

    53. Neurofibromatosis 1(NF1), diagnosis and management  

    54. Neurofibromatosis type 2 (NF2) diagnosis and management  


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