Pediatric Bone

Biology & Diseases


  • Francis Glorieux, MD, PhD, Professor of Surgery, Pediatrics and Human Genetics, McGill University; Adjunct Professor of Pediatrics, University of Montreal; Director of Research, Shriners Hospital for Children, Montreal, QC Canada

Edited by

  • John Pettifor, University of the Witwatersrand and Baragwanath Hospital, Soweto, Gauteng, SOUTH AFRICA
  • Harald Juppner, Massachusetts General Hospital, Boston, MA U.S.A

Pediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and basic scientists with a comprehensive resource covering the various aspects of bone health and disease in children
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Endocrinologists, bone biologists and biochemists, pediatricians, orthopedic surgeons and radiologists


Book information

  • Published: September 2003
  • ISBN: 978-0-12-286551-0

Table of Contents

Structure of Growth Plate and Bone MatrixBone Cell Biology: Osteoblasts, Osteocytes and OsteoclastsPrenatal Bone Development: Ontogeny and RegulationPostnatal Bone Growth: Growth Plate Biology, Modeling and RemodelingParathyroid Hormone and Calcium HomeostasisPhosphate homeostasis, Regulatory Mechanisms Vitamin D Biology Other Factors Controlling Bone Growth and Development- Calcitonin, CGRP, Osteostatin, Amylin and Adrenomedullin Peak Bone Mass and its regulationPregnancy and LactationFetal Mineral HomeostasisNon-invasive Techniques for Bone Mass MeasurementAssessment of maturation: Bone Age and Pubertal Assessment Biochemical Markers of Bone Metabolism Bone HistomorphometryA Diagnostic Approach to Skeletal DysplasiasSpectrum of OsteoporosisOsteogenesis Imperfecta Sclerosing Bony Dysplasia Parathyroid Disorders Fibrous Dysplasia Nutritional Rickets Metabolic Bone Disease of Prematurity Rickets Due to Hereditary Abnormalities of Vitamin D Synthesis or ActionFamilial Hypophosphatemia and Related DisordersRickets due to Renal Tubular AbnormalitiesHypophosphatasiaRenal Osteodystrophy: Pathogenesis, Diagnosis, and Treatment Bone Tumors in Children Orthopedic Problems Appendices