Parkinson's Disease and Related Disorders Part I
Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)
Edited by- William Koller, MD, PhD, Department of Neurology, UNC-Chapel Hill, NC, USA
- Eldad Melamed, MD, Department of Neurology, Rabin Medical Center, Petaq Tiqva, Israel
This volume provides a complete guide to advancements made in the understanding of Parkinsons disease and related neurodegenerative disorders. From information on early research conducted in the 1960s, to modern clinical views of these diseases, this handbook will give clinicians and neuroscientists a state-of-the-art reference that presents critical appraisals on recent developments in the study of these disorders.
As the world population in developed countries ages, these observations are particularly relevant. Dramatic data on the genetic causes of dominant and recessive forms of hereditary Parkinsons disease are presented, as well as new knowledge on the differences in the intricate circuitry of basal ganglia in healthy individuals and those afflicted with Parkinsons.
Clinicians will find this to be a great platform on which to base ongoing investigative approaches and research.Handbook of Clinical Neurology
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Published: June 2007
Imprint: Elsevier
ISBN: 978-0-444-51900-9
Reviews
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The Volume I on Parkinsons Disease in the Handbook of Clinical Neurology series covers, in fact, the scientific background, general aspects of Parkinsons Disease, clinical aspects and aetiology; it also covers a group of disorders that constitute the commonest of neurodegenerative diseases and one that is assuming ever greater importance with the ageing of the population in developed countries. The coverage reflects the dramatic advances in understanding of the biochemical background of Parkinsonism and the resulting developments in the pharmacological management of the disease.
This volume gives a comprehensive account of the subject for both clinical neurologists and those researching in the neurosciences.
In summary, this book demystifies, enlightens, and educates; an outstanding accomplishment; the style is uniform and the text reader-friendly punctuated with useful tables, and the clinical descriptions and practical approach to patient management are what make this an exceptional text. General neurologists, movement disorders fellows, and internists will all find this book an excellent source.
Reviewed by Mohammad Zeibo, Department of Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103, USA
30 July 2007
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Contents
- Section 1: Scientific foundation
Anatomy and physiology of the basal ganglia: relevance to parkinsons disease and related disorders. Functional neurochemistry of the basal ganglia. Dopamine receptor pharmacology.
Section 2: General aspects of Parkinson's disease
History of Parkinsons disease. Epidemiology of Parkinsons disease. Neurochemistry of the basal ganglia in Parkinsons disease. The neuropathology of parkinsonism. Imaging Parkinsons disease. Parkinsons disease: animal models.
Section 3: Clinical aspects
Scales to measure parkinsonism. Motor symptoms in Parkinsons disease. Autonomic dysfunction in Parkinsons disease. Sleep in Parkinson syndromes. Sensory symptoms in Parkinsons disease. Speech disorders in Parkinsons disease and the effects of pharmacological, surgical and speech treatment with emphasis on Lee Silverman voice treatment. Clinical features, pathophysiology and treatment of dementia associated with Parkinsons disease. Disorders of mood and affect in Parkinsons disease. Neurobehavioral disorders in Parkinsons disease. Early detection of Parkinsons disease.
Section 4: Etiology
Mitochondria in the etiology of Parkinsons disease. Iron as a trigger of neurodegeneration in Parkinsons disease. Oxidative stress and Parkinsons disease. Neurotrophic factors and Parkinsons disease. Neuroinflammation and Parkinsons disease. Excitotoxicity. Protein handling dysfunction in Parkinsons disease. Programmed cell death in Parkinsons disease.
