Palladium in Heterocyclic Chemistry, 20 book cover

Palladium in Heterocyclic Chemistry, 20

A Guide for the Synthetic Chemist

After an inordinately long induction period, organopalladium chemistry has finally been embraced by synthetic organic chemists. Currently, it is being utilized across the spectrum of organic synthesis, from applications to complex natural product syntheses to the synthesis of polymers. A substantial portion of organopalladium methodology has been developed in the context of heterocyclic chemistry and applications to heterocyclic syntheses abound.

In this new book, Jack Li and Gordon Gribble have compiled an impressive array of richly referenced examples of the use of palladium in heterocyclic chemistry. The book is organized by class of heterocycle (pyrroles, indoles, pyridines, etc.) and each chapter contains the syntheses of heterocyclic precursors as well as details of uses of palladium to both synthesize and functionalize these heterocyclic systems. This book will appeal to anybody involved in heterocyclic chemistry, and will provide an easy entry into the field for those unfamiliar with the area.

To view sample pages of Palladium in Heterocyclic Chemistry, click here.

Audience
For graduate students of chemistry and synthetic organic chemists in academia and industry, especially those involved in the fields of medicinal and agricultural chemistry.

,

Published: November 2000

Imprint: Pergamon

ISBN: 978-0-08-043705-7

Reviews

  • "This volume is the latest contribution from the well-regarded Tetrahedron Organic Chemistry Series, and it continues the tradition of this series for providing practicing organic chemists with timely, well-written, and well-researched overviews of topics of contemporary interest. The current volume collects together numerous examples of the burgeoning and often diverse field of heterocyclic synthesis via organopalladium chemistry ...a fine addition to the Tetrahedron Organic Chemistry Series and would be a valuable addition to the library of practicing organic chemists in both academe and the pharmaceutical industry."

    James.H. Rigby, Wayne State University
    Journal of the American Chemical Society, Vol 124, No 12, 2002


    "...this book is easy to read and follow and I believe will be the first point of reference for information regarding the synthesis of heterocyclic compounds employing organopalladium chemistry."

    P. Stevenson, Queen's University,
    Synthesis

Contents

  • Foreword. Preface. Abbreviations. Introduction. Oxidative coupling/cyclization. Cross-coupling reactions with organometallic reagents. The Sonogashira reaction. The Heck, intramolecular Heck and heteroaryl Heck reactions. The carbonylation reactions. The Pd-catalyzed C—P bond formation. The Buchwald-Hartwig C—N bond and C—O bond formation reactions. The Tsuji—Trost reaction. Jeffery's "ligand-free" conditions. Mori—Ban, Hegedus and Larock indole syntheses. References. Pyrroles. Synthesis of pyrrolyl halides. Oxidative coupling/cyclization. Coupling reactions with organometallic reagents. Sonogashira reaction. Heck and intramolecular Heck reactions. Carbonylation. C—N bond formation reactions. Miscellaneous. References. Indoles. Synthesis of indolyl halides. Oxidative coupling/cyclization. Coupling reactions with organometallic reagents. Sonogashira coupling. Heck couplings. Carbonylation. C—N bond formation reactions. Miscellaneous. References. Pyridines. Synthesis of halopyridines. Coupling reactions with organometallic reagents. Sonogashira reaction. Heck and intramolecular Heck reactions. C—N bond formation. Carbonylation of halopyridines. Phosphonation of halopyridines. Heteroannulation. References. Thiophenes and Benzo[b]thiophenes. Preparation of halothiophenes and halobenzothiophenes. Oxidative and reductive coupling reactions. Cross-coupling with organometallic reagents. Sonogashira reaction. Heck and intramolecular Heck reactions. Carbonylation reactions. Miscellaneous. References. Furans and Benzo[b]furans. Synthesis of halofurans and halobenzo[b]furans. Oxidative coupling/cyclization. Coupling reactions with organometallic reagents. Sonogashira reaction. Heck, intramolecular Heck and heteroaryl Heck reactions. Heteroannulation. Carbonylation and C—N bond formation. References. Thiazoles and Benzothiazoles. Synthesis of halothiazoles. Coupling reactions with organometallic reagents. Sonogashira reaction. Heck and heteroaryl Heck reactions. Carbonylation. C—N bond formation. References. Oxazoles and Benzoxazoles. Synthesis of halooxazoles and halobenzoxazoles. Coupling reactions with organometallic reagents. Sonogashira reaction. Heck and heteroaryl Heck reactions. Carbonylation. C—N bond formation. References. Imidazoles. Synthesis of haloimidazoles. Homocoupling reaction. Coupling reactions with organometallic reagents. Sonogashira reaction. Heck and heteroaryl Heck reactions. Tsuji-Trost reaction. Phosphonylation. References. Pyrazines and Quinoxalines. Pyrazines. Quinoxalines. References. Pyrimidines. Synthesis of pyrimidinyl halides and triflates. Coupling reactions with organometallic reagents. Sonogashira reaction. Heck reaction. Carbonylation. Heteroannulation. References. Subject Index.

Advertisement

advert image