PAKs, RAC/CDC42 (p21)-activated Kinases

Towards the Cure of Cancer and Other PAK-dependent Diseases

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.

This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins.

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This book will be of interest to pharmaceutical scientists and other biomedical research scientists, clinical doctors and even patients who suffer from PAK-dependent diseases.


Book information

  • Published: February 2013
  • Imprint: ELSEVIER
  • ISBN: 978-0-12-407198-8


"Here neurologists and other biomedical researchers explain in some detail how PAKs - particularly the oncogenic kinases PAK1 and PAK4 and their blockers - may control various aspects of life and health, and how mammalian PAKs have functionally evolved from their ancestral origins in unicellular organisms such as yeast and amoebas through a series of mutations over millions of years."--Reference and Research Book News, August 2013

Table of Contents

Chapter 1: Functional Maturation of PAKs:  from Uni-cellular to Multi-cellular Organisms
(Masato Okada, Graham Cote, Ramesh Jha, Hiroshi Maruta) 

Chapter 2:Oncogenicity of PAKs and Their Substrates
(Hong He & Hiroshi Maruta)

Chapter 3:Natural or Synthetic Therapeutics that Block PAKs
(Hiroshi Maruta, Shanta Messerli, Ramesh Jha)

Chapter 4:PAK1 in Parasites-Host Interaction
(Jean-Philippe Semblat & Chris Doerig)

Chapter 5: PAK1 in Brain Diseases (NF, TSC, glioma, RB, epilepsy, depression, LD)
(Hiroshi Maruta & Shanta Messerli)

Chapter 6: PAK1 in Alzheimer’s and Huntington’s diseases
(Qiu-Lan Ma, Fusheng Yang, Sally Frautschy and Greg Cole)

Chapter 7: PAK1 Controls the Lifespan
(Sumino Yanase & Hiroshi Maruta)

Chapter 8: PAK 4-6 in Cancer and Neuronal Development
(Audrey Minden)