PAKs, RAC/CDC42 (p21)-activated Kinases
Towards the Cure of Cancer and Other PAK-dependent Diseases
This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.
This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins.
This book will be of interest to pharmaceutical scientists and other biomedical research scientists, clinical doctors and even patients who suffer from PAK-dependent diseases.
Hardbound, 276 Pages
Published: February 2013
Chapter 1: Functional Maturation of PAKs: from Uni-cellular to Multi-cellular Organisms
(Masato Okada, Graham Cote, Ramesh Jha, Hiroshi Maruta)
Chapter 2:Oncogenicity of PAKs and Their Substrates
(Hong He & Hiroshi Maruta)
Chapter 3:Natural or Synthetic Therapeutics that Block PAKsChapter 4:PAK1 in Parasites-Host Interaction
(Hiroshi Maruta, Shanta Messerli, Ramesh Jha)
(Jean-Philippe Semblat & Chris Doerig)
Chapter 5: PAK1 in Brain Diseases (NF, TSC, glioma, RB, epilepsy, depression, LD)Chapter 6: PAK1 in Alzheimers and Huntingtons diseases
(Hiroshi Maruta & Shanta Messerli)
(Qiu-Lan Ma, Fusheng Yang, Sally Frautschy and Greg Cole)
Chapter 7: PAK1 Controls the LifespanChapter 8: PAK 4-6 in Cancer and Neuronal Development
(Sumino Yanase & Hiroshi Maruta)