Oxygen Biology and Hypoxia

Edited by

  • Helmut Sies, Institut Fur Physiologische Chemie, Germany
  • Bernard Bruene

For over fifty years the Methods in Enzymology series has been the critically acclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume features articles on the topic of oxygen biology and hypoxia.
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Biochemists and researchers in related life science disciplines.


Book information

  • Published: November 2007
  • ISBN: 978-0-12-373970-4

Table of Contents

Section I. Hypoxia-inducible factor Chapter 1HIF PAS domains: structure and function Thomas H. Scheuermann, Jinsong Yang, Lei Zhang, Kevin H. Gardner, and Richard K. BruickChapter 2Structure-function analysis of HIF Lorenz Poellinger Chaper 3HIF Prolyl Hydroxylase: Purification and Assays of PHD2Kirsty S. Hewitson, Christopher J. Schofield, Peter J. RatcliffeChapter 4Determination and modulation of prolyl-4-hydroxylase domain (PHD) oxygen sensor activityRenato Wirthner, Kuppusamy Balamurugan, Daniel P. Stiehl, Sandra Barth, Patrick Spielmann, Felix Oehme, Ingo Flamme, Dörthe M. Katschinski, Roland H. Wenger and Gieri CamenischChapter 5Characterisation of ankyrin-repeat containing proteins as substrates of the asparaginyl hydroxylase Factor Inhibiting HIF (FIH-1).Sarah Linke, Rachel J. Hampton-Smith, Daniel J. PeetChapter 6Transgenic Models to Understand HIF FunctionAndrew Doedens and Randall S. JohnsonChapter 7The Silencing Approach of the Hypoxia Signalling Pathway"Edurne Berra and Jacques PouyssegurChapter 8Cellular and developmental adaptations to hypoxia; a Drosophila perspectiveNuria Magdalena Romero, Andrés Dekanty, Pablo WappnerSection II. Erythropoietin Chapter 9Constitutively overexpressed erythropoietin reduces infarct size in a mouse model of permanent coronary artery ligationGiovanni G. Camici, Thomas Stallmach, Matthias Hermann, Rutger Hassink, Peter Doevendans, Beat Grenacher, Alain Hirschy, Johannes Vogel, Thomas F. Lüscher, Frank Ruschitzka and Max GassmannChapter 10Control of erythropoietin gene expression and its use in medicineWolfgang JelkmannChapter 11Role of HIF-2 in endothelial development and hematopoiesisOsamu Ohneda1,3, Masumi Nagano1,3 and Yoshiaki Fujii-KuriyamaSection III. Hypoxia and adaptationChapter 12ORGAN PROTECTION BY HYPOXIA AND HIFWanja M. Bernhardt, Christina Warnecke, Carsten Willam, Michael S. Wiesener and Kai-Uwe EckardtChapter 13Hypoxia and regulation of mRNA translationMarianne Koritzinsky and Bradly G. WoutersChapter 14Hypoxia and the Unfolded Protein ResponseConstantinos Koumenis, Meixia Bi, Jiangbin Ye, Douglas Feldman and Albert C. KoongSection IV. Hypoxia and tumor biologyChapter 15Tumor hypoxia in cancer therapyJ. Martin BrownChapter 16HIF Gene Expression in Cancer TherapyBy Denise A. Chan, Adam J. Krieg, Sandra Turcotte, and Amato J. GiacciaChapter 17Analysis of HIF-1 Expression and Its Effects on Invasion and MetastasisBalaji Krishnamachary, Gregg L. Semenza Chapter 18Macrophage migration inhibitory factor (MIF) manipulation and evaluation in tumoral hypoxic adaptationMillicent Winner, Lin Leng, Wayne Zundel and Robert A. MitchellChapter 19The von Hippel-Lindau Tumor Suppressor Protein: An UpdateWilliam G. Kaelin, Jr.Chapter 20Hypoxia Inducible Factor 1 (HIF-1) inhibitorsGiovanni MelilloSection V. Hypoxia and inflammatory mediatorsChapter 21Regulation of HIF during InflammationStilla Frede, Utta Berchner-Pfannschmidt, Joachim FandreyChapter 22Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factorsAgnes Görlach, Thomas KietzmannChapter 23Genetics of mitochondrial electron transport chain in regulating oxygen sensingEric L. Bell and Navdeep S. ChandelChapter 24Hypoxia inducible factor-1 (HIF-1) under the control of nitric oxide (NO) Bernhard Brüne and Jie ZhouChapter 25Hypoxic regulation of NF-κB signallingEoin P. Cummins, Katrina M. Comerford, Carsten Scholz, Ulrike Bruning & Cormac T. Taylor