Oxidative Stress and Neurodegenerative Disorders

Edited by

  • G. Ali Qureshi, Medical Research Center, Liaquat University of Medical and Health Sciences, Pakistan
  • S. Hasan Parvez, CNRS Neuroendocrine Unit, France

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.
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Researchers, clinicians and students in the fields of neuroscience, neurology, biochemistry and drug discovery who are interested in neurodegenerative disorders.


Book information

  • Published: March 2007
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-52809-4

Table of Contents

1Advances in our understanding of Neurodegeneration.Kurt A. Jellinger.2Mitochondrial mutagenesis in the brain in forensic and pathological researchNicole von Wurmb-Schwark3Genetic and environmental factors in neurodegenerative diseases Fabio Copped√ɬ® and Lucia Migliore4Nitric oxide and cellular stress response in brain aging and neurodegenerative disordersVittorio Calabrese, Cesare Mancuso, Carlo De Marco, Anna Maria Giuffrida Stella and D. Allan Butterfield.5Oxidative Stress and Radiation-induced Late Normal Tissue InjuryM.E.C. Robbinsand W. Zhao6Oxidative stress-induced death in the nervous system: cell cycle dependent for independent?Brett C. Langley7Redox imbalance in Parkinson√ʬĬôs disease.Daniela Berg.8Genes and Oxidative Stress in Sporadic and Familial Parkinsonism : cDNA Microarray Studies.Youdum M.B.H., Grunblatt E, Mandel S, Riederer P.9Down syndrome, antioxidant balance and the √ʬĬúgene dosage effect√Ę¬Ä¬Ě hypothesis.Judy de Haan, P.J. Crack, M. Pritchard and I. Kola10The role of levodopa in the chronic neurodegenerative disorder Parkinson√ʬĬôs disease.Thomas Muller.11Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients.Prof. K. Christou, K.I. Gourgoulianis.12The Key Role of Oxidative Stress in Alzheimer Disease.George Perry, Mark A. Smith, Paula I. Moreira, Akihiko Nunomura, Kazuhiro Honda, Gjumrakch Aliev, Gemma Casadesus, Xiongwei Zhu.13The role of oxidative stress in the pathogenesis of multiple sclerosis: Current state.Nirit Lev, Yossi Gilgun-Sherki, Daniel Offen, Eldad Melamed.14Oxidative stress and neuroinflammation in Alzheimere√ʬĬôs disease and amyotrophic lateral sclerosis: From Biology to Therapeutic Strategies.Molina Mhatre, Kenneth Hensley.15Oxidative Stress in Stroke.Margarita L. Alexandrova and Petyo G. Bochev.16Hyperoxidation of the two catechol amines, Depamine and Adrenaline: Implications for the Etiiologies and Treatment of Encephalitis Lethargica, Parkinson;s disease, Multiple sclerosis, Amyotrophic Lateral Sclerosis and Schizophrenia.Harold D. Foster, Abram Hoffer.17The role of metals and their effect on oxidative stress in amyotrophic lateral sclerosis. Maria Teresa Carr.18Neurotransmission and coexistence of neurotransmitters in Parkinson√ʬĬôs disease.G.Ali Qureshi.19Manganese-Induced Oxidative Stress: Truth or FictionAllison W. Dobson20Prospects for Antioxidant Therapy in Mild Cognitive Impairment and Alzheimer√ʬĬôs Disease.Mark A. Smith.21An assessment of the chances of antiapoptotic drug therapy in patients with neurodegenerative disorders.Peter C. Waldmeier.22Role of Antioxidant Activity of Estrogens in their Potent Neuroprotection.James W. Simpkins, Ph.D. and Evelyn Perez, Ziaofei Wang.23Diet, Herbs, and Nutritional Protection Against Oxidative Stress in Neurological Diseases.Carlos Kusano Bucalen Ferrari, PhD24Diabetic Neuropathy: Pathogenesis and Treatment.Maria Siemionow, MD, PhD, DsC Yalcin Kulahci, MD, Galip Agaoglu, MD25Green and Black Tea in Brain Protection.Elzbieta Skrzydlewska, Justyna Ostrowska, Wojciech Lluczaj, Agnieszka Augustyniak.26Environmental and genetic interactions: key to sporadic Parkinson√ʬĬôs disease?Fai. TSANG, & Tuck Wah SOONG27Prevention and Therapy of Neurodegenerative Disorders: Role of Nutritional Antioxidants.Ennio Esposito, MD, Vincenzo Di Matteo, Massimo Pierucci, and Giuseppe Di Giovanni.28Genetics of Parkinson√ʬĬôs disease.Yue Huang, Piu Chan, Glenda Halliday.29Biomarkers of hypoxic brain injury.Buonocore Giuseppe30Role of Iron, Zinc and Copper in Parkinson patients.G.Ali Qureshi, S. Ali Shuja, and S. H.Parvez31Oxidative stress in phagocytic cell : changes with age and effect of melatoninCarmen Barriga, M.P. Terron, H.Parvez, J.Cubero, D.Narciso, S.D.Paredes, S.Sanchez and A.B.Rodriquez