Edited by

  • Robert Marcus, MD, Emeritus, Department of Medicine, Stanford University School of Medicine, CA, USA
  • David Feldman, Division of Endocrinology, Stanford University School of Medicine, Stanford, California, USA
  • Robert Marcus, MD, Emeritus, Department of Medicine, Stanford University School of Medicine, CA, USA
  • David Feldman, Stanford University School of Medicine, Stanford, California, USA
  • Dorothy Nelson, Wayne State University, Detroit, MI, U.S.A.
  • Clifford Rosen, The Jackson Laboratory, Bar Harbor, Maine, U.S.A.

Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year.
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Academic and medical libraries as well as professionals in bone biology, endocrinology, osteology, neuroendocrinology; drug companies developing osteoporosis medications


Book information

  • Published:
  • ISBN: 978-0-12-370544-0


Praise for Previous Editions: "...Osteoporosis is quite comprehensive; indeed, topics that typically receive brief treatment elsewhere (osteoporosis in minority groups and in men) receive entire chapters here..." -THE NEW ENGLAND JOURNAL OF MEDICINE

Table of Contents

IntroductionThe Bone Organ System: Form and FunctionThe Nature of OsteoporosisThe Economics of OsteoporosisReflections on OsteoporosisSkeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of OsteoporosisBasic Science/Bone BiologyOsteoblast BiologyOsteoclast BiologyOsteocytesThe Regulatory Role of Matrix Proteins in Mineralization of BoneDevelopment of the SkeletonMouse Genetics as a Tool to Study Bone Development and PhysiologyParathyroid Hormone and Parathyroid Hormone-Related ProteinVitamin D: Biology, Action, and Clinical ImplicationsRegulation of Bone Cell Function by EstrogensAndrogens and Skeletal Biology: Basic MechanismsPhosphatoninsWnt Signaling in BoneCytokines and Bone RemodelingSkeletal Growth FactorsIntercellular Communication During Bone RemodelingStructural and BiomechanicsSkeletal Development: Mechanical Consequences of Growth, Aging and DiseaseInhibition of Osteoporosis by Biophysical InterventionBiomechanics of Age-Related FracturesBone QualityEpidemiology & Risk FactorsEpidemiologic Methods in Studies of OsteoporosisRace, Ethnicity and OsteoporosisThe Study of Osteoporotic Fractures (SOF): Major Findings and ContributionsBone Mineral Acquisition in Utero and During Infancy and ChildhoodBone Acquisition in Adolescence Genetic Determinants of Osteoporosis Nutrition and Risk for Osteoporosis Physical Activity in Prevention of Osteoporosis and Associated Fractures Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis Non-Skeletal Risk Factors for Osteoporosis and Fractures Falls as Risk Factors for Fracture Assessment of Fracture Risk Outcomes of Osteoporotic Fractures PathophysiologyLocal and Systemic Factors in the Pathogenesis of Osteoporosis Animal Models for Osteoporosis Estrogen, Bone Homeostasis and OsteoporosisPostmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization Osteoporosis in Childhood and Adolescence Glucocorticoid-Induced Osteoporosis Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach Mechanisms of Immobilization-induced Bone Loss Leptin-Dependent Regulation of Bone Mass Thyroid Hormone and the Skeleton Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis Osteoporosis Associated with Illnesses and Medications Transplantation Osteoporosis Osteoporosis Associated with Cancer Therapy Osteoporosis Associated with Pregnancy Osteoporosis Associated with Rheumatologic Disease Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks Localized Osteoporosis Evaluation and ManagementEvaluation of the Patient with Osteoporosis or at Risk for Osteoporosis Who Should be Screened: Who Should be Treated? Radiology of Osteoporosis Clinical Use of Bone Densitometry Biochemical Markers of Bone Turnover in Osteoporosis The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis An Orthopedic Perspective of OsteoporosisLessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs Pharmacology and TherapeuticsDesign Considerations for Clinical Investigations of Osteoporosis Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials Evidence-Based Osteoporosis Care The Role of Calcium in the Treatment of Osteoporosis Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis Estrogen Therapy: Prevention and Treatment of Osteoporosis Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and PhytoestrogensBisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis Calcitonin in Osteoporosis Strontium Therapy for Osteoporosis Androgens Treatment with PTH Peptides Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis New approaches to Osteoporosis Therapeutics