Osteoporosis, Two-Volume Set book cover

Osteoporosis, Two-Volume Set

Osteoporosis is the most comprehensive, authoritative reference on this disease. Some of the topics covered include basic biology, anatomy, physiology, pathophysiology, preclinical issues, experimental medicine, management, and therapeutics. Written by renowned experts in this field, this book is a must-have for the researcher, the academic clinician, or anyone in the field of bone biology.

Researchers, professionals, and academic clinicians in bone, endocrinology, and related disciplines.


Published: August 2001

Imprint: Academic Press

ISBN: 978-0-12-470862-4


  • m:Praise for the First Edition
    Praise for the First Edition, --NEW ENGLAND JOURNAL OF MEDICINE

    "The editors have managed to produce a work which is interesting, comprehensive and up-to-date..."


  • ContributorsPrefaceVOLUME 1Part I Introduction to Normal Bone Physiology and PathophysiologyChapter 1 The Bone Organ System: Form and FunctionCassandra A. Lee and Thomas A. EinhornChapter 2 Osteoblast BiologyJane B. Lian and Gary S. SteinChapter 3 Osteoclast BiologyF. Patrick Ross and Steven L. TeitelbaumChapter 4 The Biochemistry of BoneJayashree A. Gokhale, Pamela Gehron Robey, and Adele L. BoskeyChapter 5 Developmental Biology of BoneAnthony M. Reginato, Wenfang Wang, and Bjorn R. OlsenChapter 6 Mouse Genetics as a Tool to Study Bone Development and PhysiologyMillan S. Patel and Gerard KarsentyChapter 7 Parathyroid Hormone and Parathyroid Hormone-Related ProteinRobert A. NissensonChapter 8 CalcitoninAna O. Hoff, Gilbert J. Cote, and Robert F. GagelChapter 9 Vitamin D: Biology, Action, and Clinical ImplicationDavid Feldman, Peter J. Malloy, and Coleman GrossChapter 10 Regulation of Bone Cell Function by EstrogensBarry S. Komm and Peter V. N. BodineChapter 11 Skeletal Biology of AndrogensKristine M. Wiren and Eric S. OrwollChapter 12 Coupling of Bone Resorption and Formation during Bone RemodelingThomas J. Martin and Gideon A. RodanChapter 13 Cytokines and Bone RemodelingGregory R. Mundy, Babatunde Oyajobi, Kathy Traianedes, Sarah Dallas, and Di ChenChapter 14 Bone Growth FactorsXuezhong Qin, Reinhard Gysin, Subburaman Mohan, and David J. BaylinkChapter 15 Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of OsteoporosisA. M. ParfittChapter 16 Basic Biology of BisphosphonatesH. FleischPart II Structure and BiomechanicsChapter 17 Skeletal Development: Mechanical Consequences of Growth, Aging, and DiseaseMarjolein C. H. van der Meulen, Dennis R. Carter, and Gary S. BeaupréChapter 18 Inhibition of Osteopenia by Biophysical InterventionClinton T. Rubin and Kenneth J. McLeodChapter 19 Biomechanics of Age-Related FracturesMary L. BouxseinPart III Epidemiology and Risk FactorsChapter 20 Introduction to Epidemiologic MethodsJennifer L. Kelsey and MaryFran SowersChapter 21 Magnitude and Impact of Osteoporosis and FracturesL. Joseph Melton III and Cyrus CooperChapter 22 Race, Ethnicity, and OsteoporosisMarie Luz Villa, Lorene Nelson, and Dorothy NelsonChapter 23 Epidemiology of Osteoporosis Fractures: The European ExperienceChris de Laet and Jonathan ReeveChapter 24 Bone Mineral Acquisition in Utero, during Infancy, and throughout ChildhoodBonny Specker, Ran Namgung, and Reggie C. TsangChapter 25 Bone Acquisition in AdolescenceJean-Philippe Bonjour and Rene RizzoliChapter 26 Genetics and Genomics of OsteoporosisAndré G. Uitterlinden, Johannes P. T. M. van Leeuwen, and Huibert A. P. PolsChapter 27 Nutrition and Risk for OsteoporosisRobert P. HeaneyChapter 28 Physical Activity and OsteoporosisBelinda R. Beck, Janet Shaw, and Christine M. SnowChapter 29 Premenopausal Reproduction and Hormonal Characteristics and Risk for OsteoporosisMaryFran SowersChapter 30 Postmenopausal Endogenous and Exogenous Hormones, Degree of Obesity, Thiazide Diuretics, and Risk of OsteoporosisJane A. Cauley and Loran M. SalamoneChapter 31 The Effects of Tobacco and Alcohol Use on BoneEgo SeemanChapter 32 Falls as Risk Factors for FracturesAnne Schwartz, Elizabeth Capezuti, and Jeane Ann GrissoChapter 33 Assessing Fracture RiskCharles W. Slemenda, C. Conrad Johnston, and Siu L. HuiChapter 34 Outcomes of Osteoporotic FracturesElizabeth Barrett-Conner and Gail GreendaleVOLUME 2Part IV PathophysiologyChapter 35 The Nature of OsteoporosisRobert Marcus and Sharmilla MajumderChapter 36 Local and Systemic Factors in the Pathogenesis of OsteoporosisLawrence R. RaiszChapter 37 Animal Models for in Vivo Experimentation in Osteoporosis ResearchDonald B. KimmelChapter 38 The TypeI/Type II Model for Involutional Osteoporosis: Update and Modification Based on New ObservationsB. Lawrence Riggs, Sundeep Khosla, and L. Joseph Melton IIIChapter 39 Bone Remodeling Findings in OsteoporosisRobert R. Recker and M. Janet Barger-LuxChapter 40 The Role of Parathyroid Hormone and Vitamin D in the Pathogenesis of OsteoporosisJohn P. Bilezikian and Shonni J. SilverbergChapter 41 Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone LossRoberto PacificiChapter 42 Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical CharacterizationEric S. Orwoll and Robert F. KleinChapter 43 Osteoporosis in Childhood and AdolescenceLaura K. BachrachChapter 44 Glucocorticoid-Induced Osteoporosis: Basic Pathological Mechanisms, Clinical Features, and Management in the New MillenniumGary M. Leong, Jacqueline R. Center, N. Kathryn Henderson, and John A. EismanChapter 45 Familial OsteoporosisAlan L. Burshell and Steven R. SmithChapter 46 Immobilization OsteopeniaB. Jenny KiratliChapter 47 Thyroid Hormone and the SkeletonDaniel BaranChapter 48 Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic DiseasesDaniel D. BikleChapter 49 Primary Hyperparathyroidism and Hyperparathyroid Bone DiseaseLorraine A. Fitzpatrick and Hunter Heath IIIChapter 50 Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult OsteoporosisJay R. ShapiroChapter 51 Osteoporosis Secondary to Illnesses and MedicationsAdina Schneider and Elizabeth ShaneChapter 52 Transplantation OsteoporosisSol Epstein and Elizabeth ShaneChapter 53 Osteoporosis Associated with PregnancyLynn Kohlmeier and Robert MarcusChapter 54 Osteoprosis Associated with Rheumatologic DisordersSteven R. GoldringChapter 55 Oral Bone Loss and Systemic OsteopeniaMarjorie K. Jeffcoat, Michael S. Reddy, and Arthur A. DecarloPart V Evaluation and ManagementChapter 56 Localized OsteoporosisD. J. Schurman, W. J. Maloney, and R. L. SmithChapter 57 The Evaluation of the Patient with Osteoporosis or at Risk for OsteoporosisMichael KleerekoperChapter 58 Imaging of OsteoporosisMichael Jergas and Harry K. GenantChapter 59 Clinical Use of Bone DensitometryKenneth G. FaulknerChapter 60 Biochemical Markers of Bone Turnover in OsteoporosisP. Garnero and P. D. DelmasChapter 61 Osteoporosis and Its Nonskeletal Consequences: Their Impact on Treatment DecisionsDeborah T. Gold, Kenneth W. Lyles, Kathy M. Shipp, and Marc K. DreznerChapter 62 An Orthopedic Perspective of OsteoporosisMichael H. Heggeness and Kenneth B. MathisChapter 63 Clinical Use of Bone BiopsyP. Chavassieux, M. Arlot, and P. J. MeunierPart VI Pharmacology and TherapeuticsChapter 64 Design Considerations for Clinical Investigations of OsteoporosisRobert P. HeaneyChapter 65 Development and Evaluation of New Drugs for OsteoporosisHenry BoneChapter 66 Evidence-Based Decision Making in OsteoporosisAnn B. Cranney and Gordon H. GuyattChapter 67 The Role of Calcium in the Treatment of OsteoporosisBess Dawson-HughesChapter 68 Vitamin D and Its Metabolites in the Management of OsteoporosisIan R. ReidChapter 69 Estrogens and OsteoporosisRobert Lindsay and Felicia CosmanChapter 70 Selective Estrogen Receptor Modulators (SERMs)Ethel S. Siris and Douglas B. MuchmoreChapter 71 Phytoestrogen and Other Phytochemical Effects on BoneRichard PrinceChapter 72 Bisphosphonates in the Management of Postmenopausal OsteoporosisSocrates E. PapapoulousChapter 73 CalcitoninRoberto CivitelliChapter 74 Fluoride Therapy for OsteoporosisK.-H. William Lau and David J. BaylinkChapter 75 A New Perspective on Fluoride TherapyCharles Y. C. PakChapter 76 Androgens and Andogenic ProgestinsSundeep KhoslaChapter 77 Treatment with PTH PeptidesLis Mosekilde and Jonathan ReeveChapter 78 Growth Hormone and Insulin-Like Growth Factors: Potential Applications and Limitations in the Management of OsteoporosisChristian Wüster and Clifford RosenChapter 79 New Approaches to Osteoporosis TherapeuticsS. Aubrey Stoch, Michael Chorev, and Michael RosenblattIndex


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