Osteoporosis in Men book cover

Osteoporosis in Men

The Effects of Gender on Skeletal Health

Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men.

This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger - 8.5 x 11. This edition  of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.

Academic, medical, and pharmaceutical researchers in bone biology, endocrinology, and rheumatology; Medical researchers in pediatrics, internal medicine, orthopedics, primary care, geriatrics, obstetrics and gynecology, oncology, and nephrology.

Hardbound, 741 Pages

Published: November 2009

Imprint: Academic Press

ISBN: 978-0-12-374602-3


  • "The editors of Osteoporosis in Men, Second Edition have produced a comprehensive compendium about osteoporosis as it relates to men. An established group of experts has contributed to the second edition of this excellent book. The topics range from the basics of osteoporosis to sections on growth of the skeleton, aging, importance of nutrition, sex hormones, and the development of the disorder. Key sections of clinical relevance including diagnosis and treatment of osteoporosis in men are covered in depth. This book will serve as an excellent resource for established clinicians and investigators as well as for students and fellows."

    --Richard Eastell, MD, FRCP, FRCPath, FMedSci, Professor of Bone Metabolism, Director of the NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom

    "The 10 sections and total of 57 informative chapters in the second edition of the text Osteoporosis in Men constitute an impressive body of up-to-date information by leading experts on this important topic. The text is particularly useful because of its breadth extending from basic bone biology and environmental factors affecting skeletal development in men to clinical chapters on pathophysiology, diagnosis, and therapy. The editors have provided a comprehensive yet practical approach to the topic which makes the text useful to a broad potential audience ranging from trainees to established leaders in the field."

    -- John T. Potts, Jr., MD, Director of Research and Physician-in-Chief emeritus, Massachusetts General Hospital, Jackson Distinguished Professor of Clinical Medicine, Harvard Medical School, Boston, MA, USA

    "This thorough and comprehensive book integrates new, accessible, and informative material in the field. It will help investigators, as well as practitioners and students, to improve their understanding of male skeletal health and male skeletal loss. The additional knowledge, assembled in such a readable manner, should help us achieve one of our ultimate goals, namely better care of men with osteoporosis."

    --Gerolamo Bianchi, MD, Department of Locomotor System, Division of Rheumatology, Azienda Sanitaria Genovese, Genova, Italy


  • Section 1 - Essentials of bone biology

    1. The Biochemistry of Bone: Composition and Organization
    2. Adele L. Boskey

    3. Bone Remodeling: Cellular Activities in Bone
    4. David W. Dempster, Hua Zhou, Shi Shou Lu

    5. Assessment of Bone Turnover Using Biochemical Markers
    6. Patrick Garnero, Pawel Szulc

    7. Fundamentals of Mineral Homeostasis
    8. David A. Hanley, Shawn K. Davison

    9. The Mechanical Properties of Bone
    10. David P. Fyhrie

    11. Assessment of Bone Architecture
    12. Thomas F. Lang


      Section 2 - Development and growth of the male skeleton

    13. Skeletal Growth in Males
    14. Qingju Wang, Ego Seeman

    15. Pubertal Growth of the Male Skeleton
    16. Vincent Gilsanz, Stefano Mora

    17. The Effects of Sex Steroids on Bone Growth
    18. Giampiero I. Baroncelli, Silvano Bertelloni

    19. Nutritional Basis of Skeletal Growth
    20. Connie M. Weaver, Elizabeth Haney

    21. Physical Activity and Skeletal Growth
    22. Heather M. Macdonald, Heather A. McKay, Melonie Burrows


      Section 3 - Skeletal genetics

    23. The Genetics of Peak Bone Mass
    24. Luigi Gennari, Robert F. Klein, Serge Ferrari

      Section 4 - Aging and the male skeleton

    25. Age-Related Changes in Bone Remodeling and Micro Architecture
    26. Roger Zebaze, Ego Seeman

    27. Markers of Bone Remodeling and the Aging Skeleton
    28. Serge Cremers, Christian Meier, Markus J. Seibel

    29. Alterations in Mineral Metabolism in the Aging Male
    30. Shonni J. Silverberg, Bismruta Misra

    31. Change in Bone Size and Geometry with Aging
    32. Pawel Szulc

    33. Aging and Bone Density
    34. Steven Boonen, Filip Callewaert, Katrien Venken, Dirk Vanderschueren

    35. The Effect of Age on Material Properties
    36. Charles H. Turner, Matt Allen, David Burr

      Section 5, Nutritional issues

    37. Calcium, Bone Strength and Fractures
    38. Laura A.G. Armas, David P. Heaney, Joan M. Lappe

    39. Vitamin D and Bone
    40. Roger Bouillon, Christa Maes, Lieve Verlinden, Geert Carmeliet, Annemieke Verstuyf

    41. Role of Dietary Protein in Bone Growth and Bone Loss
    42. Rene Rizzoli


      Section 6 - Sex steroids and the skeleton in men

    43. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes
    44. Stavroula Kousteni

    45. Estrogen and the Skeleton - Rodents
    46. Dirk Vanderschueren, Katrien Venken, Filip Callewaert, Steven Boonen

    47. Estrogen and the Skeleton - Humans
    48. Liesbeth Vandenput, Claes Ohlsson

    49. Androgens and the Skeleton - Animal Models
    50. Kristine Wiren, Eric Orwoll

    51. Androgens and the Skeleton - Humans
    52. Benjamin Z. Leder

    53. Androgen Effects on the Skeletal Muscle
    54. Shalender Bhasin, Rajan Singh, Ravi Jasuja, Thomas W. Storer

      Section 7 - Fractures in men

    55. Epidemiology of Fractures
    56. Shreyasee Amin

    57. Individualized Progress of Fractures in Men
    58. Tuan V. Nguyen , John A. Eisman

    59. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men
    60. Peggy Mannen Cawthon, Lynn Marshall

    61. Economic Impact of Osteoporotic Fractures (vs women)
    62. Terence O’Neill

    63. Adverse Health Outcomes in Men with Osteoporosis
    64. Deborah T. Gold, Stuart L. Silverman


      Section 8. Metabolic bone disease in men

    65. Idiopathic Osteoporosis
    66. Jean-Marc Kaufman, Bruno Lepauw, Youri Taes, Stefan Goemeare

    67. Glucocorticoid Induced Osteoporosis
    68. Andrea Giustina, Gherardo Mazziotti

    69. Testicular Dysfunction
    70. David J. Handelsman, Christian Meier, Markus J. Seibel

    71. Alcohol and Bone
    72. Neil Binkley

    73. Transplantation Osteoporosis
    74. Elizabeth Shane, Juliet E. Compston, Emily Stein

    75. Management of Fractures in Men with Impaired Renal Function
    76. Paul D. Miller

    77. Hyperparathyroidism
    78. John P. Bilezikian, Claudio Marccoci

    79. Hypercalciuria
    80. Murray J. Favus

    81. The Skeletal Phenotype of the Male Athlete
    82. Clifford J. Rosen, Ann E. Maloney

    83. Inherited and Related Disorders of Bone Matrix Synthesis in Men
    84. Jay R. Shapiro


      Section 9 - Diagnostic approach

    85. Dual-Energy X-ray Absorptiometry (DXA) in Men
    86. Neil C. Binkley, Robert A. Adler

    87. Quantitative Ultrasound Diagnosis of Osteoporosis in Men
    88. Robert A. Adler, Neil C. Binkley

    89. Advanced Structural Assessment of Bone Using CT and MRI
    90. X. Edward Guo, X. Sherry Liu, Felix W. Wehrli

    91. Vertebral Fracture Assessments
    92. Piet Geusens, Willem Lems

    93. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis
    94. Erik F. Eriksen, Johan Halse

    95. Overall diagnostic strategy
    96. Eric Orwoll

      Section 10 - Therapy

    97. Diagnostic Thresholds for Osteoporosis in Men
    98. John A. Kanis, Anders Oden, Helena Johansson, Eugene V. McCloskey

    99. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges
    100. John T. Schoesboe

    101. Nutritional Therapy for Skeletal Health in Men
    102. Deborah E. Sellmeyer, Diana M. Antoniucci

    103. Exercise Programs for Patients with Osteoporosis
    104. Dieter Felsenberg, Martin Runge

    105. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications
    106. Sunil J. Wimalawansa

    107. Treatment of Male Osteoporosis with Bisphosphonates
    108. Socrates E. Papapoulos, Andrea Giusti

    109. Treatment of Male Osteoporosis with Parathyroid Hormone
    110. Monica Giotra, Felicia Cosman, John P. Bilezikian

    111. Testosterone Therapy for Osteoporosis in Men

    Kishore M. Lakshman, Andre B. Araujo, Shalendar Bhasin

    57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon

    Ghada El-Hajj Fuleihan, Mahmoud Tabbal


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