Interactions of the Immune and Skeletal Systems

Edited by

  • Joseph Lorenzo, University of Connecticut Health Center, Farmington, CT, USA
  • Mark Horowitz, Yale University School of Medicine, New Haven, CT, USA
  • Yongwon Choi, University of Pennsylvania, Philadelphia, PA, USA
  • Hiroshi Takayanagi, Tokyo Medical and Dental University, Tokyo, Japan
  • Georg Schett, University of Erlangen-Nuremberg, Germany

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology.

This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics.

Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis.

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Book information

  • Published: September 2015
  • ISBN: 978-0-12-800571-2

Table of Contents

1. Overview

  Joseph Lorenzo, Mark Horowitz, Yongwon Choi, Hiroshi Takayanagi and Georg Schett

2. Innate and Adaptive Immunity and Bone

  Hector Leonardo Aguila

3. Origins of the Osteoclast

  Mary C. Nakamura, Julia F. Charles and Antonios O. Aliprantis

4. Trafficking of Osteoclast Precursors

  Joao Pereira, Junichi Kikuta and Erin Nevius

5. Osteoclast Biology: Regulation of Formation and Function

  Yongwon Choi and Hiroshi Takayanagi

6. Osteoblasts and the Immune system

  Mark Nanes

7. Osteocyte Biology

  Charles A. O'Brien

8. Bone Cells and the Hematopoietic Niche

  Henry M. Kronenberg and Joy Y. Wu

9. The Function of RANKL Beyond the Osteoclast

  Josef Penninger and Verena Sigl

10. The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells

  Joseph Lorenzo

11. Coupling Between Immune and Bone Cells

  Natalie A. Sims, Jack Martin and Julian Quinn

12. The Role of the Immune System in the Development of Osteoporosis and Fracture Risk

  Piet Geusens, Steven R. Goldring, Karine Briot and Christian Roux

13. The Role of Sex Steroiods in the Interactions of the Immune System with Bone

  Sun-Kyeong Lee, Danka Grcevic and Natasa Kovacic

14. The Role of the Immune System in the Local and Systemic Bone Loss of Inflammatory Arthritis

  Ellen M. Gravallese, Steven R. Goldring and Georg Schett

15. Osteoarthritis and the Immune System

  Mary B. Goldring, Steven R. Goldring and Jean-Michel Dayer

16. Inflammatory Bowel Disease and Bone

  Francisco A. Sylvester

17. The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis

  Edward M. Schwarz, Kohei Nishitani, Sheila Bello-Irizarry, Karen L. de Mesy Bentley and John Daiss

18. The Role of the Immune System in Fracture Healing

  Louis Gerstenfeld and Thomas Einhorn

19. The Role of the Immune System in the Effects of Cancer on Bone

  G. David Roodman

20. Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement)

  Dana Graves

21. The Role of the Immune System in the Interactions of Fat and Bone

  Ryan Berry, Jackie A. Fretz, Anne Klibanski, Clifford J. Rosen, Matt Rodeheffer and Mark Horowitz