Osteoimmunology book cover


Interactions of the Immune and Skeletal Systems

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology.

This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics.

Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis.

Hardbound, 554 Pages

Published: September 2015

Imprint: Academic Press

ISBN: 978-0-12-800571-2


  • 1. Overview

      Joseph Lorenzo, Mark Horowitz, Yongwon Choi, Hiroshi Takayanagi and Georg Schett

    2. Innate and Adaptive Immunity and Bone

      Hector Leonardo Aguila

    3. Origins of the Osteoclast

      Mary C. Nakamura, Julia F. Charles and Antonios O. Aliprantis

    4. Trafficking of Osteoclast Precursors

      Joao Pereira, Junichi Kikuta and Erin Nevius

    5. Osteoclast Biology: Regulation of Formation and Function

      Yongwon Choi and Hiroshi Takayanagi

    6. Osteoblasts and the Immune system

      Mark Nanes

    7. Osteocyte Biology

      Charles A. O'Brien

    8. Bone Cells and the Hematopoietic Niche

      Henry M. Kronenberg and Joy Y. Wu

    9. The Function of RANKL Beyond the Osteoclast

      Josef Penninger and Verena Sigl

    10. The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells

      Joseph Lorenzo

    11. Coupling Between Immune and Bone Cells

      Natalie A. Sims, Jack Martin and Julian Quinn

    12. The Role of the Immune System in the Development of Osteoporosis and Fracture Risk

      Piet Geusens, Steven R. Goldring, Karine Briot and Christian Roux

    13. The Role of Sex Steroiods in the Interactions of the Immune System with Bone

      Sun-Kyeong Lee, Danka Grcevic and Natasa Kovacic

    14. The Role of the Immune System in the Local and Systemic Bone Loss of Inflammatory Arthritis

      Ellen M. Gravallese, Steven R. Goldring and Georg Schett

    15. Osteoarthritis and the Immune System

      Mary B. Goldring, Steven R. Goldring and Jean-Michel Dayer

    16. Inflammatory Bowel Disease and Bone

      Francisco A. Sylvester

    17. The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis

      Edward M. Schwarz, Kohei Nishitani, Sheila Bello-Irizarry, Karen L. de Mesy Bentley and John Daiss

    18. The Role of the Immune System in Fracture Healing

      Louis Gerstenfeld and Thomas Einhorn

    19. The Role of the Immune System in the Effects of Cancer on Bone

      G. David Roodman

    20. Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement)

      Dana Graves

    21. The Role of the Immune System in the Interactions of Fat and Bone

      Ryan Berry, Jackie A. Fretz, Anne Klibanski, Clifford J. Rosen, Matt Rodeheffer and Mark Horowitz


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