Interactions of the Immune and Skeletal Systems

Edited by

  • Joseph Lorenzo, University of Connecticut Health Center, Farmington, CT, USA
  • Mark Horowitz, Yale University School of Medicine, New Haven, CT, USA
  • Yongwon Choi, University of Pennsylvania, Philadelphia, PA, USA
  • Yongwon Choi, University of Pennsylvania, Philadelphia, PA, USA
  • Hiroshi Takayanagi, Tokyo Medical and Dental University, Tokyo, Japan
  • Georg Schett, University of Erlangen-Nuremberg, Germany
  • Hiroshi Takayanagi, Tokyo Medical and Dental University, Tokyo, Japan

Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. Critical interactions between these two organ systems frequently occur, particularly in the development of immune cells in the bone marrow and for the function of bone cells in health and disease. This book provides a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated.
The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology--all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact.
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Book information

  • Published: August 2010
  • ISBN: 978-0-12-375670-1


"Edited by four pioneers in the field of osteoimmunology, this book contains chapters by 44 outstanding experts, spanning the breadth and depth of our current knowledge of osteoimmunology from cell and molecular biology to clinical problems."

--Tatsuo Suda, Member of the Japan Academy, Associate Member, Science Council of Japan, Emerutus Professor of Showa University, Visiting Professor, Research Center for Genomic Medicine, Saitama Medical University, Japan

"The new textbook of osteoimmunology provides a comprehensive introduction to this recently established field that seeks to bridge two-well established disciplines. By reviewing both well-established concepts in bone biology and recent advances in our understanding of the interactions between the immune and skeletal systems, the text serves as both an excellent introduction to the field and a state of the art summary. Overall, each chapter provides concise history of work in the area, thus both immunologists and bone biologists can gain a view of how current paradigms evolved to their current states. This makes the book of particular use to trainees that have studied primarily immunology or bone biology in the past but know little about the other. Early chapters focus on specific cell types in the bone such as osteoclasts or osteoblasts and review both the cellular differentiation and function and our current knowledge regarding immune regulation of the cells. Later chapters nicely focus on specific pathologic states in the bone such as inflammatory arthritis or fracture healing and provide a comprehensive review of studies investigating the role of the immune system in these models. The field of osteoimmunology is rapidly expanding and evolving quickly, this textbook will help put all of us on the same page and help us understand how we got here."

--Mary C. Nakamura M.D., Associate Professor of Medicine, UCSF, Division of Rheumatology, San Francisco, CA, USA

Table of Contents

Chapter 1 Overview: The developing Field of Osteoimmunology Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi, Joseph LorenzoChapter 2The Origins of Bone Cells: Osteoclasts G. David Roodman, Deborah L. GalsonChapter 3Adaptive Immune ResponseDavid G. Hesslein, Hector L. Aguila, Mark C. HorowitzChapter 4The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche Henry Kronenberg, Joy WuChapter 5 The Signaling Pathways Regulating Osteoblast Differentiation Jane Lian, Gary SteinChapter 6The Signaling Pathways Regulating Osteoclast DifferentiationSteven Teitelbaum, Roberta Faccio, Hiroshi Takayanagi, Yongwon ChoiChapter 7The Effects of Immune Cells Products (Cytokines and Growth Factors) on Bone Cells Joseph LorenzoChapter 8Interactions of Osteoblasts and Osteoclasts T. John Martin, Natalie A. Sims, Julian M. W. Quinn Chapter 9The Role of the Immune System in the Development of Osteoporosis Sundeep Khosla, B. Lawrence Riggs, Ulrike I. Moedder Chapter 10The Role of the Immune System in the Bone Loss of Inflammatory ArthritisGeorg Schett, Steven GoldringChapter 11 The Role of the Immune System in the Bone Loss of Inflammatory Bowel Disease Francisco Sylvester, Anthony T. VellaChapter 12The Role of the Immune System in Fracture HealingLouis Gerstenfeld, Thomas Einhorn, Brandon SteenChapter 13 The Role of the Immune System in the Development of Chronic Infections of BoneBrendan Boyce, Edward Schwarz, Lianping XingChapter 14 The Role of the Immune System in Hematologic Malignancies, which Affect BoneGregory Mundy, Claire M. Edwards, Jessica FowlerChapter 15The Role of the Immune System in Dental DiseaseDana Graves, Rayyan A. Kayal, Thomas Oates, Gustavo Garlet