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Organic Chemistry Concepts and Applications for Medicinal Chemistry
1st Edition - April 14, 2014
Author: Joseph E. Rice
Language: English
Paperback ISBN:9780128007396
9 7 8 - 0 - 1 2 - 8 0 0 7 3 9 - 6
eBook ISBN:9780128008324
9 7 8 - 0 - 1 2 - 8 0 0 8 3 2 - 4
Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular…Read more
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Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams.
Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding
Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more
Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material
Advanced students moving from organic chemistry to medicinal/pharmaceutical chemistry; exam takers in pharmacy, medicine, etc; professionals in chemistry and pharmaceutics who require review for practice
Dedication
Preface
Chapter 1. Bonding in Organic Compounds
Atomic Orbitals
Hybrid Orbitals
Resonance
Aromaticity
Chapter 2. The Three-Dimensional Structure of Organic Compounds
Isomers
Stereoisomerism at Saturated Centers
Prochirality
Stereoisomerism at Unsaturated Centers
Conformations
Chapter 3. Functional Groups
Common Functional Groups
The Electronic Effects of Functional Groups
Chapter 4. Acids and Bases
Brønsted–Lowry Acids and Bases
Ionization
Estimating Acid/Base Strength
Lewis Acids and Bases
Chapter 5. Partition Coefficients
What is a Partition Coefficient?
Effect of Structure on Partition Coefficients
Chapter 6. The Nomenclature of Cyclic and Polycyclic Compounds
Common Heterocycles
Fused-Ring Systems
Substituents and Saturation
Bridged Rings
Spiro Rings
Special Classes of Compounds
Chapter 7. Drug Metabolism
Phase I: Oxidative Processes
Phase I: Reductions
Phase I: Hydrolysis
Phase II: Conjugation
Miscellaneous Phase II Processes
Index
No. of pages: 224
Language: English
Edition: 1
Published: April 14, 2014
Imprint: Academic Press
Paperback ISBN: 9780128007396
eBook ISBN: 9780128008324
JR
Joseph E. Rice
Joseph Rice received his Ph.D. in Organic Chemistry from the Polytechnic Institute of New York in 1982. He worked at the American Health Foundation in Valhalla, NY for six years doing research on chemical carcinogenesis and became Head of the Section of Metabolic Chemistry. His research involved the synthesis of potential carcinogenic metabolites of polycyclic aromatic hydrocarbons. In 1988, he joined the faculty of the Medicinal Chemistry Department of the Ernest Mario School of Pharmacy at Rutgers University. He has been teaching Medicinal Chemistry to 4th year undergraduates for 25 years. In 2001, the author spearheaded the creation of a Graduate Program in Medicinal Chemistry and served as its director until 2012. He is actively involved in teaching three graduate courses- Medicinal Chemistry: Research Techniques and Principles, Heterocycles in Medicinal Chemistry, and Strategies and Tactics in Synthetic Medicinal Chemistry. His current research interest is the synthesis of selective G-quadruplex-stabilizing macrocyclic polyoxazoles as a new class of anticancer agents. The author has published over 60 papers in the area of the synthesis of compounds of biological interest.
Affiliations and expertise
Rutgers,the State University of New Jersey, Piscataway, NJ, USA
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