Nonviral Vectors for Gene Therapy

Edited By

  • Mien-Chie Hung, M.D. Anderson Cancer Center, University of Texas, Houston, U.S.A.
  • Leaf Huang, School of Medicine, University of Pittsburgh, Pennsylvania, U.S.A.
  • Ernst Wagner, Institute of Biochemistry, Vienna University Biocenter, Austria


Book information

  • Published: June 1999
  • ISBN: 978-0-12-358465-6


Chapters are written by leading experts and recognized authorities in the field, and the editors have done a remarkable job of ensuring that the level of presentation remains constant throughout... The book is well illustrated, and includes several pages of color plates and a functional index... This volume is a succinct, readable introduction to the development and use of nonviral vectors in gene therapy, and should serve to stimulate further research into this field. Its appeal, however, is not limited to those working in gene therapy. It should also be read by molecular biologists and especially cell biologists, whose work on basic cellular mechanisms of uptake and transport are needed to further an understanding of how to design effective vectors for gene therapy."

Table of Contents

Introduction, L.Huang and E. Viroonhatapan.Cationic Liposomes:Progress in Gene Delivery Research and Development, P. Felgner.Cationic Lipid-Mediated Gene Delivery to the Airways, J. Marshall, N. Yew, S. Eastman, C. Jiang, R. Scheule, S. Cheng.Structure and Structure-Activity Relationship of Lipid-Based Gene Delivery Systems, D. Lasic.Self-Assembled Structures of Lipid/DNA Nonviral Gene Delivery Systems from Synchorotron X-Ray Diffraction, C. Safinya, I. Koltover.Sites of Uptake and Expression of Cationic Liposome/DNA Complexes Injected Intravenously, J. McLean, G. Thurston, D. McDonald.Other Vectors:Nuclear Transport of Exogenous DNA, M. Sebestyén and J. Wolff.Particle-Mediated Gene Delivery: Applications to Canine and Other Larger Animal Systems, N.-S. Yang, G. Hogge, E.G. MacEwen.Polyethylenimines: A Family of Potent Polymers for Nucleic Acid Delivery, A. Kichler, J.-P. Behr, P. Erbacher.Ligand-Polycation Conjugates for Receptor-Targeted Gene Transfer, E. Wagner.The Perplexing Delivery Mechanism of Lipoplexes, L. Barron and F. Szoka, Jr..Biopolymer-DNA Nanospheres, K. Leong.Novel Lipidic Vectors for Gene Transfer, S. Li, L. Huang.Animal Models and Clinical Trials:Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium, D. Liu, J. Knapp, Y. Song.Cystic Fibrosis Gene Therapy, U. Griesenbach, D. Geddes, E. Alton.Targeting HER-2/neu-Overexpressing Cancer Cells with Transcriptional Repressor Genes Delivered by Cationic Liposome, M.-C. Hung, S.-C. Wang, G. Hortobagyi.Immune Pathways Used in Nucleic Acid Vaccination, G. Rhodes.A Novel Gene Regulatory System, S. Chua, M. Burcin, Y. Wang, S. Tsai.Index.