New Models of the Cell Nucleus: Crowding, Entropic Forces, Phase Separation, and Fractals book cover

New Models of the Cell Nucleus: Crowding, Entropic Forces, Phase Separation, and Fractals

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2012: 4.973.

Ideas from the fields of biophysics, physical chemistry, of polymer and colloid, and soft matter science have helped clarify the structure and functions of the cell nucleus. The development of powerful methods for modeling conformations and interactions of macromolecules has also contributed. The book aims to encourage cell and molecular biologists to become more familiar with and understand these new concepts and methods, and the crucial contributions they are making to our perception of the nucleus.


Cell biologists, molecular biologists, developmental biologists, physiologists (organ level), biomedical scientists, biochemists studying cell-cell interactions, cell variation and evolution

Hardbound, 512 Pages

Published: January 2014

Imprint: Academic Press

ISBN: 978-0-12-800046-5


    1. The Nuclear Physique
      Thoru Pederson
    2. The Crowded Nucleus
      Ronald Hancock
    3. Crowding in Polymer-Nanoparticle  Mixtures
      Alan R. Denton
    4. Crowding-Induced Formation and Structural Alteration of Nuclear Compartments: Insights from Computer Simulations
      Eun Jin Cho, Igal Szleifer and Jun Soo Kim
    5. Phase Separation as a Possible Means of Nuclear Compartmentalization
      William M. Aumiller, Jr, Bradley W. Davis and Christine D. Keating
    6. Formation of Multi-Protein Assemblies in the Nucleus: The Spindle Assembly Checkpoint (SAC)
      Victor M. Bolanos-Garcia
    7. Characteristic Behavior of Crowding Macromolecules Confined in Cell-Sized Droplets
      Miho Yanagisawa, Takahiro Sakaue and Kenichi Yoshikawa
    8. Non-Canonical Structures and their Thermodynamics of DNA and RNA Under Molecular Crowding: Beyond the Watson-Crick Double Helix
      Naoki Sugimoto
    9. Computational Models of Large-Scale Genome Architecture
      Angelo Rosa and Christophe Zimmer
    10. How Chromatin Looping and Nuclear Envelope Attachment Affect Genome Organization in Eukaryotic Cell Nuclei
      Hansjoerg Jerabek and Dieter W. Heermann
    11. Crowding, Diffusion, and Biochemical Reactions
      Matthias Weiss
    12. Importance of Crowding in Signaling, Genetic, and Metabolic Networks
      Pieter Rein ten Wolde and Andrew Mugler
    13. Relevance and Limitations of Crowding, Fractal, and Polymer Models to Describe Nuclear Architecture
      Sébastien Huet, Christophe Lavelle, Hubert Ranchon, Pascal Carrivain, Jean-Marc Victor and Aurélien Bancaud


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