Neurovirology book cover


Handbook of Clinical Neurology Series (Series Editors: Aminoff, Boller, Swaab)

This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology.

Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on molecular medicine. These advances are particularly important today with the introduction of emerging and re-emerging diseases such as HIV/AIDS, Nipah encephalitis and the appearance of West Nile encephalitis in the western hemisphere.


Clinical neurologists at tertiary centers and neuroscience researchers

Hardbound, 808 Pages

Published: August 2014

Imprint: Elsevier

ISBN: 978-0-444-53488-0


  • Section 1 Introduction
    1. A History of Viral Infections of the Central Nervous System: Foundations, Milestones, and Patterns 
    2. Basics of virology 
    3. Neuroepidemiology and the Epidemiology of Viral Infections of the Nervous System 
    4. Clinical Approach to the Syndromes of Encephalitis, Myelitis and Meningitis   
    5. Laboratory Diagnosis of Viral Disease  
    6. Neuroimaging of Viral Infections of the Central Nervous System  
    7. Viral Neuropathogenesis  
    8. Neuropathology of viral infections 
    9. Innate immune viral recognition: relevance to CNS infections 
    10. Adaptive immune response to viral infections in the central nervous system
    Section 2 DNA viruses
    11. Herpes simplex virus 
    12. Varicella zoster 
    13. Epstein-Barr virus infections of the nervous system 
    14. Cytomegalovirus infections of the adult human nervous system 
    15. Congenital Cytomegalovirus Infection 
    16. Human herpesvirus-6 and the nervous system 
    17. Progressive multifocal leukoencephalopathy 
    Section 3  RNA viruses
    18. Enterovirus/Picornavirus infections 
    19. The equine encephalitides 
    20. West Nile and St. Louis encephalitis viruses 
    21. The Bunyaviridae 
    22. Human endogenous retroviruses and the nervous system 
    23. Central Nervous System HIV-1 Infection 
    24. Neurological disease due to HTLV-1 infection 
    25. Tick-Borne Encephalitis  
    26. Japanese Encephalitis Virus Infection 
    27. Measles virus and the nervous system  
    28. Mumps and rubella 
    29. Rabies 
    30. Neurologic aspects of influenza viruses 
    31. Neurological complications of hepatic viruses 
    32. Henipavirus Encephalitis 
    33. Diseases of the Central Nervous System Caused by Lymphocytic Choriomeningitis Virus and other Arenaviruses 
    Section 4  Other Topics Concerning Viral or Presumed Viral Infections of the CNS
    34. Nervous system viral infections in immunocompromised hosts 
    35. Acute Disseminated Encephalomyelitis 
    36. Vaccines and viral / toxin associated neurological infections 
    37. Encephalitis Lethargica (von Economo's encephalitis) 
    38. Bell’s Palsy and Vestibular Neuronitis


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