Neuroregulatory Mechanisms in AgingEdited by
- M.H. Makman, Departments of Biochemistry and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
- G.B. Stefano, Old Westbury Neuroscience Institute and Multidisciplinary Center for the Study of Aging, State University of New York/College at Old Westbury, New York 11568-0210, USA
Aging and its associated problems are of increasing interest and concern as the life expectancy of the human population increases. The importance of continued functioning of the nervous system in cognitive and integrative processes, necessary for maintaining the quality of life during aging, is self evident. The nature and extent of the changes that occur with increasing age differ considerably in different species and also in the various organs or tissues within a given species. This volume is the first to consider the process of aging, with particular emphasis on "normal" aging, as it applies to the nervous systems of man and other mammals, as well as to certain invertebrates. Changes in human brain function due to Alzheimer's disease are considered in addition to changes that may occur with "normal" human aging. The potential involvement of immunocytes in age-associated disorders is also discussed. Leading experts describe the changes that occur in the brain and in the nervous system, generally, due to aging, from molecular, pharmacological, electrophysiological and behavioral perspectives. This book emphasizes the attempts of recent research to understand the basic mechanisms for these changes, as well as their functional consequences and provides important insight into our understanding of the aging process and the consequences of these changes for neuronal function. Topics considered include neuropeptides systems in aging, including opioids and analgesic, cholinergic and aminergic systems, neuroendocrinology and neuroimmunology.
For neurobiologists and those interested in the biology of aging from a variety of perspectives, including physiologists, biochemists, and pharmacologists.
Pergamon Studies in Neuroscience
Published: November 1993
- Introduction and perspectives on the neurobiology of aging (M.H. Makman, G.B. Stefano). The effects of acetylcholine and aging on electrical excitability of the central nervous system (D.O. Carpenter et al.). Alterations in muscarinic cholinergic neurotransmission in normal aging and Alzheimer's disease: implications for current therapeutic strategies for treatment of dementia (E.E. El-Fakahany, J.A. Joseph). Influence of normal aging on monoamines, monoamine receptors and associated signal transduction systems (M.H. Makman). Altered calcium homeostasis during aging of the brain: cellular mechanisms involved and possible consequences (J. Satrústegui et al.). Adrenal glucocorticoids as modulators of brain aging (M.J. Meaney et al.). Neuroimmunological processes and aging (G.B. Stefano et al.). Aging and analgesic mechanism (R.J. Bodnar, G.W. Pasternak). The pond snail Lymnaea stagnalis - an animal model for aging studies in the central nervous system (C. Janse). Alterations of opioid regulatory mechanisms associated with aging (G.B. Stefano). Index.