Neuronal Cell Death and RepairEdited by
- A.C. Cuello, McGill University, Montreal, PQ., Canada
This unique book deals with concepts and experimental possibilities which could not have been anticipated 10 years ago. Recent hard evidence that neuronal cells in the central nervous system possess a capability for recovery after trauma well beyond that previously recognized poses many fundamental and secondary questions. For example: is there a programmed cell death phenomenon in the mature brain? Under what circumstances do neurotransmitters promote trophic responses in neurons or provoke cell death? How might environmental or toxic molecules be responsible for specific neuronal damage? These and many other questions were extensively discussed at the Madrid conference on which this volume is partly based. Various additional invited papers comprise this excellent work on neuronal cell death and repair.
Published: July 1993
- List of Contributors. Preface. Section I. Cellular and Molecular Mechanisms for Neuronal Cell Death. Chapter 1. An introduction to apoptosis (G.T. Williams, C.A. Smith, N.J. McCarthy, E.A. Grimes). 2. Apoptosis (I.D. Bowen). 3. Molecular mechanism of programmed cell death in the developing nervous system (E.M. Johnson Jr, E.B. Cornbrooks, T.L. Deckwerth, S. Estus, J.L. Franklin, R.S. Freeman, K. Horigome, P.A. Lampe). 4. Neurotrophic factors and apoptosis in the nervous system (A. Batistatou, L.A. Greene). 5. The microtubule cytoskeleton in neuronal development and degeneration (J. Avila, I. Correas, J. García de Ancos, D. Ledesma, L. Ulloa, E. Montejo de Garcini, J. Díaz-Nido). 6. Molecular biology and pathology of Alzheimer's disease (K. Beyreuther, G. Multhaup, C.L. Masters). Section II. Chemically Induced Neuronal Cell Death. 7. Excitatory amino acids and free radicals in the genesis of ischemic neuronal death (F. Moroni, G. Lombardi, M. Alesiani, F. Moroni). 8. Cell death: a tough business (D.W. Choi). 9. Anatomical, physiological and behavioral effects of chronic MK-801 administration to adult and developing rats (M. Nieto-Sampedro, C. Bailón, F. Rivas, M.T. Moreno). 10. MPTP and neurotoxins induced neuronal cell death (J. Del Rio, I. Pérez-Otaño, M. Trinidad Herrero, J.A. Obeso). 11. Adrenal glucocorticoids as modulators of hippocampal neuron survival, repair and function in the aged rat (M.J. Meaney, S.R. Bodnoff, D. O'Donnell, A. Sarrieau, N.P.V. Nair, D.M. Diamond, G.M. Rose, J. Poirier, J.R. Seckl). Section III. Experimental Recovery of Lesion-Induced Neuronal Cell Death and Atrophy. 12. Neurotrophins and neurodegenerative diseases (F. Zafra). 13. Neurotrophic effects on afferent neurons in the developing, adult and aged cholinergic basal forebrain (J.D. Cooper, M.V. Sofroniew). 14. Atrophy and regrowth of CNS forebrain neurons. Models of study and clinical relevance (A.C. Cuello, P. Liberini, P. Piccardo). 15. Manipulating macrophages in nervous system repair (V.H. Perry, M.C. Brown, P.B. Andersson). Section IV. DNA Synthesis and Neurogenesis in the Adult Brain 16. Are new neurons formed in the brain of adult mammals? (J. Altman, S.A. Bayer). 17. Neurogenesis and neuronal replacement in adult birds (F. Nottebohm, A. Alvarez-Buylla). 18. Postnatal neurogenesis and regeneration in the lizard cerebral cortex (C. Lopez-Garcia). 19. EGF-responsive stem cells in the mammalian central nervous system (B.A. Reynolds, S. Weiss). 20. Constraints on neurogenesis in adult primate brain: an evolutionary advantage? (P. Rakic, D.R. Kornack). 21. Neurogenesis in the adult rat hippocampus: lesion stimulated phenomenon? (M. Skup, D.G. Herrera, A. Ribeira-da-Silva, A.C. Cuello). 22. Recombination activating gene-1 (RAG-1) transcription in the mammalian CNS: implications and future directions (J.J.M. Chun). 23. Neurogenesis and oncogenesis (M. Szyf). Subject index.