Neuromuscular Disorders of Infancy, Childhood, and Adolescence

A Clinician's Approach

Edited by

  • Basil Darras, Children's Hospital, Boston, MA, USA
  • H. Royden Jones, Jr., Children's Hospital, Boston, MA, USA
  • Monique Ryan, Royal Children's Hospital, Parkville, Victoria, Australia
  • Darryl De Vivo, Columbia University Medical Center, New York, NY, USA

Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science, diagnosis and treatment of neuromuscular disorders in childhood is a timely and needed resource for all clinicians and researchers studying neuromuscular disorders, especially in childhood. The Second Edition is completely revised to remain current with advances in the field and to insure this remains the standard reference for clinical neurologists and clinical research neurologists. The Second Edition retains comprehensive coverage while shortening the total chapter count to be an even more manageable and effective reference.
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Clinical Neurologists, Pediatric Neurologists, Neuroscience Researchers, Clinical Research Neurologists


Book information

  • Published: November 2014
  • ISBN: 978-0-12-417044-5

Table of Contents

SECTION I.  Clinical and Laboratory Approach to the Infant and Child with a Neuromuscular Problem
1. Introduction: Historical Perspectives
  Darryl C. De Vivo, Basil T. Darras, Monique M. Ryan, and H. Royden Jones, Jr.
2. Genetics of Neuromuscular Disorders
  Wendy K. Chung
3. Electromyography in Pediatrics
  Matthew Pitt and Peter B. Kang
4. Muscle Biopsy for Diagnosis of Neuromuscular and Metabolic Diseases
  Harvey B. Sarnat and Stirling Carpenter
5. Nerve Biopsy 
  Jo M. Wilmshurst, Pedro Ciarlini and Umberto De Girolami

SECTION II.  Infantile Hypotonia and Arthrogryposis
6. Neonatal Hypotonia
  Joseph J. Volpe
7. Arthrogryposis
  Judith G. Hall and Angela Vincent

SECTION III.  Motor Neuron Disorders
8. Spinal Muscular Atrophies
  Basil T. Darras, Jennifer A. Markowitz, Umrao R. Monani and Darryl C. De Vivo
9. Juvenile Amyotrophic Lateral Sclerosis
  Jemeen Sreedharan and Robert H. Brown, Jr.
10. Infectious or Acquired Motor Neuron Diseases
  Manikum Moodley, William S. David and Alan R. Seay
11. The Stiff-man Syndrome in Children and Adolescents
  Jennifer A. Tracy and Andrew McKeon

SECTION IV.  Peripheral Nerve Disorders

Radiculopathies and Plexopathies
12. Radiculopathies and Plexopathies
  H. Royden Jones, Jr., Monique M. Ryan and Kerry H. Levin

13. Congenital and Acquired Facial Palsies 
  Francis Renault and Susana Quijano-Roy
14. Mononeuropathies
  Monique M. Ryan, H. Royden Jones, Jr.

15. Overview of Pediatric Peripheral Neuropathies
  Hugh J. McMillan and Monique M. Ryan
16. Congenital and Early Infantile Neuropathies
  Eppie M. Yiu and Jonathan Baets
17. Hereditary Neuropathies in Late Childhood and Adolescence
  Kathryn M. Brennan and Michael E. Shy
18. Hereditary Sensory and Autonomic Neuropathies
  Felicia B. Axelrod and Horacio Kaufmann
19.  Peripheral Neuropathy in Inherited Metabolic Disease
  Marc C. Patterson and Alan K. Percy
20. Acute Polyneuropathies
  H. Royden Jones, Jr., Padraic J. Grattan-Smith and Monique M. Ryan
21. Chronic Inflammatory Demyelinating Polyradiculoneuropathy
  Hugh J. McMillan and Peter B. Kang
22. Neuropathies Secondary to Systemic Disorders
  Jo M. Wilmshurst and Robert A. Ouvrier
23. Toxic Neuropathies
  David Pleasure
24. Hansen's Disease (Leprosy): Leprous Neuropathy
  Wilson Marques Jr.

SECTION V.  Neuromuscular Junction Disorders
25. Acquired Presynaptic Neuromuscular Junction Disorders: Infant Botulism and Lambert-Eaton Myasthenic Syndrome
  Ai Sakonju and Thomas O. Crawford
26. Congenital Myasthenic Syndromes
  Andrew G. Engel
27. Juvenile and Neonatal Myasthenia Gravis
  Peter B. Kang, Wendy K. M. Liew, Maryam Oskoui and Angela Vincent

SECTION VI.  Myopathies
28. Congenital and Other Structural Myopathies
  James J. Dowling, Kathryn North, Hans H. Goebel and Alan H. Beggs
29. Congenital Muscular Dystrophies
  Eugenio Mercuri and Francesco Muntoni
30. Dystrophinopathies
  Basil T. Darras, Caroline C. Menache Starobinski, Veronica J. Hinton and Louis M. Kunkel
31. Clinical Management of Dystrophinopathies: A Systematic Approach
  Michela Guglieri and Kate Bushby
32. Facioscapulohumeral Dystrophy
  Wendy K. M. Liew, Silvère M. van der Maarel and Rabi Tawil
33. Distal Myopathies
  Bjarne Udd
34. Limb-Girdle Muscular Dystrophies
  Payam Mohassel and Carsten G. Bönnemann
35. Emery-Dreifuss Muscular Dystrophy: Nuclear Envelopathies
  Hacer Durmus, Piraye Serdaroglu-Oflazer and Feza Deymeer
36. Myopathies of Systemic Disease
  Thornton B.A. Mason, II and Darryl C. De Vivo
37. Myotonic Dystrophy
  Richard T. Moxley, III, Emma Ciafaloni and Debra Guntrum
38. Muscle Channelopathies: Myotonias and Periodic Paralyses
  Karin Jurkat-Rott, Reinhardt Rüdel, Frank Lehmann-Horn
39. Glycogen Storage Diseases of Muscle
  Hasan O. Akman, Anders Oldfors and Salvatore DiMauro
40. Lipid Storage Myopathies due to Fatty Acid Oxidation Defects
  Ingrid Tein
41. Mitochondrial Encephalomyopathies
  Darryl C. De Vivo, Carmen Paradas and Salvatore DiMauro
42. Juvenile Dermatomyositis and Other Inflammatory Myopathies in Children
  Lauren M. Pachman

SECTION VII.  Special Clinical Problems
43. Neuromuscular Problems of the Critically Ill Neonate and Child  
  Basil T. Darras and H. Royden Jones, Jr.
44. Intensive Care Management, Including Cardiorespiratory Care
  William A. Scott and Susan T. Iannaccone
45. Malignant Hyperthermia: An Inherited Disorder of Muscle Calcium Metabolism
  Werner Klingler and Frank Lehmann-Horn
46. Disorders of the Ocular Motor Cranial Nerves and Extraocular Muscles
  Monique M. Ryan and Elizabeth C. Engle
47. Oromotor Dysfunction in Neuromuscular Disorders: Evaluation and Treatment
  Manuel Roig-Quilis
48. Complex Regional Pain Syndromes I and II (Reflex Sympathetic Dystrophy, Causalgia)
  Navil F. Sethna and Deirdre E. Logan

49. Friedreich Ataxia
  Massimo Pandolfo
50. Dominantly Inherited Spinocerebellar Syndromes
  Stephen M. Maricich and Huda Y. Zoghbi

SECTION VIII.  General Therapeutic Principles 
51. Principles and Practice of Molecular Therapies
  Louise R. Rodino-Klapac and Jerry R. Mendell
52. Orthopedic Management
  David P. Roye, Evan D. Sheha and Nanfang Xu
53. Rehabilitation of the Child with a Neuromuscular Disorder
  Nancy E. Strauss, Jacqueline Montes, Barry S. Russman
54. Outcome Measures in Neuromuscular Diseases
  Jacqueline Montes and Petra Kaufmann