Neurobiology of the Locus Coeruleus

Edited by

  • C.D. Barnes
  • O. Pompeiano

This volume contains the presentations resulting from a three day world symposium held at Post Falls, Idaho, U.S.A., on May 16-19, 1990, entitled `The Neurobiology of the Locus Coeruleus'. The conference answered a definite need for establishing a focus amid the rapidly accumulating information available. Leading scientists had pursued valuable research work on the neurochemical anatomy of the LC, the membrane properties of neurons, and many other facets of this important neuroscientific area.

This volume sheds light not only on this pioneering research work, but also on some of the major discrepencies which had arisen from these fast developments and the large amounts of information surfacing therefrom. Contributors gathered to present the fruits of their personal research efforts and to pool common ideas to stimulate and challenge those presently engaged in research on the LC. An excellent book, essential to neuroscientists and neurophysiologists involved with the locus coeruleus.

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Book information

  • Published: November 1991
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-81394-7


...a luxurious publication, not only because of the quality of print, but for the quality of the illustrations and the content as well. There is an enormous wealth of information available to a variety of neuroscientists...a must for locus coeruleus interested researchers...

Table of Contents

List of contributors. Preface. Section I. Anatomy of the locus coeruleus, its afferents and efferents. 1. Neurochemicals in the dorsal pontine tegmentum 2. Noradrengergic locus coeruleus neurons: their distant connections and their relationship to neighboring--including cholinergic and GABAergic--neurons of the central gray and reticular formation. 3. Physiological properties and afferent connections of the locus coeruleus and adjacent tegmental neurons involved in the generation of paradoxical sleep in the cat 4. Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology5. Noradrenergic innervation of somatosensory thalamus and spinal cord. 6. Efferent projections of different subpopulations of central noradrenaline neurons. 7. Pontospinal transmitters and their distribution . 8. The projections of locus coeruleus neurons to the spinal cord. 9. Ultrastructural aspects of the coeruleospinal projection. Section II. Properties of locus coeruleus neurons. 10. Single unit and physiological analyses of brain norepinephrine function in behaving animals. 11. Synaptic potentials in locus coeruleus neurons in brain slices. 12. Developmental aspects of the locus coeruleus-noradrenaline system. 13. GABAA and GABAB receptors and the ionic mechanisms mediating their effects on locus coeruleus neurons. 14. Mechanisms of opioid actions on neurones of the locus coeruleus. 15. Afferent effects on locus coeruleus in opiate withdrawal . 16. Angiotensin II and the locus coeruleus. 17. Vasopressin immunoreactive fibers and neurons in the dorsal pontine tegmentum of the rat, monkey and human . 18. Responses of Locus Coeruleus neurons to neuropeptides. 19. Pharmacology of locus coeruleus spontaneous and sensory-evoked activity. 20. Selective effects of DSP-4 on locus coeruleus axons: are there pharmacologically different types of noradrenergic axons in the central nervous system? Section III: Noradrenergic influences on target neurons. 21. Distribution of catecholamine receptors. 22. Actions of norepinephrine in the cerebral cortex and thalamus: implications for function of the central noradrenergic system. 23. Noradrenergic and locus coeruleus modulation of the perforant path-evoked potential in rat dentate gyrus support a role for the Locus Coeruleus in attentional and memorial processes. 24. Actions of norepinephrine in the rat hippocampus. 25. The cerebellar norepinephrine system: inhibition, modulation, and gating. 26. Norepinephrine effects of spinal motoneurons. 27. Second messenger-mediated actions of norepinephrine on target neurons in central circuits: a new perspective on intracellular mechanisms and functional consequences. Section IV: Control of motor and sensory systems. 28. Central noradrenergic neurons: the autonomic connections. 29. Descending noradrenergic influences on pain. 30. locus coeruleus control of spinal motor output. 31. Responses of locus coeruleus neurons to labyrinth and neck stimulation. 32. Locus coeruleus and pontine reticular influences on the gain of vestibulospinal reflexes. 33. Noradrenergic agents into the cerebellar anterior vermis modify the gain of vestibulospinal reflexes in the cat. 34. Effects of GABAergic and noradrenergic injections into the cerebellar flocculus on vestibulo-ocular reflexes in the rabbit. Section V. Locus coeruleus influences on higher functions and plasticity. 35. Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. 36. Electrophysiological evidence for the involvement of the locus coeruleus in alerting orienting, and attending. 37. The role of noradrenergic Locus coeruleus neurons and neighboring cholinergic neurons of the pontomesencephalic tegmentum in sleep-wake states. 38. Effects of local pontine injection of noradrenergic agents on desynchronized sleep of the cat. 39. Facilitation of learning consecutive to electrical stimulation of the locus coeruleus: cognitive alteration or stress-reduction?. 40. Plasticity of sensory responses of locus coeruleus neurons in the behaving rat: implications for cognition. 41. Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment. 42. Adrenergic regulation of visuocortical plasticity: a role of the locus coeruleus system. 43. Regulation of locus coeruleus neuron development in vitro. 44. Alterations in the locus coeruleus in dementias of Alzheimer's and Parkinson's disease. Subject index.