Neurobiology of Epilepsy and Aging

Edited by

  • R. Eugene Ramsay, International Center for Epilepsy, University of Miami, FL, USA

This volume in the International Review of Neurobiology series addresses the epidemiology, pathophysiology, and treatment of epilepsy in elderly patients. Demographically, the elderly comprise both the fastest-growing segment of the U.S. population and the adult age group with the highest incidence of epilepsy, yet there are relatively few publications devoted to this clinical subgroup. The intersection of these two complex processes-epilepsy and advancing age-will have an increasing impact on medical and community care. The etiology, prognosis, and differential diagnosis of epilepsy can all be affected by the normal aging process and by the frequent comorbidities encountered in an elderly population. Chapters in this book review the effects of aging on brain function and on drug metabolism and interactions, covering the gamut of research from animal models of aging and epilepsy to clinical trials and outcomes. Topics also include the dangers of misdiagnosing status epilepticus, the special issues encountered in recruiting and retaining elderly clinical trial participants, and the use of antiepileptic drugs in the elderly. In both the clinic and the research laboratory, a better understanding of how epilepsy may differ between younger and older patients will be valuable in determining the best possible care for geriatric patients with epilepsy.
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Book information

  • Published: April 2007
  • ISBN: 978-0-12-374018-2

Table of Contents

Title TBDTable of Contents Author Title1 Nancy L. Nadon, PhD Principles of Animal Use for Gerontological Research2 John H. Morrison, PhD Life & Death of Neurons in Aging Cerebral Cortex3 Robert J. DeLorenzo, MD, PhD Poststroke Seizures: In Vitro Modeling4 H. Steve White, PhD Mechanisms of AEDs: Matching the Drug with the Older Patient5 Alan R. Towne, MD Epidemiology & Outcomes of Status Epilepticus in the Elderly6 Dan Berlowitz, MD, MPH Pharmacoepidemiology in Community-dwelling Elderly Taking AEDs7 Judy Garrard, PhD Pharmacoepidemiology in Elderly Nursing Home Residents Taking AEDs8 Emilio Perucca, MD Age-related Changes in Pharmacokinetics: Predictability and Assessment Methods9 Angela Birnbaum, PhD AED Disposition in Elderly Nursing Home Residents10 Mary Jo Pugh, PhD Impact of Epilepsy & its Treatment in Older Veterans11 Rene Levy, PhD Risk & Predictability of Drug Interactions in the Elderly12 Martin J. Brodie, MD(written by Linda Stephen, MD) Treatment of Newly Diagnosed Epilepsy in the Elderly13 A. James Rowan, MDR. Eugene Ramsay, MD Outcome of VA Coop Study #428 - Treatment of Seizures in the Elderly Population14 Flavia Pryor, RN, BSN Recruitment/Retention in Clinical Trials of the Elderly15 Matthew Walker, MD Treatment of Seizure Emergencies: Non-Convulsive Status Epilepticus16 Barry Gidal, PharmD Impact of Formulation in Treating Elderly with Epilepsy