Neurobiology of Disease


  • Sid Gilman, Department of Neurology, University of Michigan, Ann Arbor, MI, USA

This book is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.
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Scientists and researchers in neuroscience, neurology, neurosurgery, psychiatry, physical medicine and rehabilitation, as well as graduate students and fellows preparing for board examinations.


Book information

  • Published: November 2006
  • ISBN: 978-0-12-088592-3


"I think [the book] is very valuable, and it has benefited from careful editing and good organization. ...The illustrations are excellent β€” color has been used judiciously and effectively. ...The number of undergraduate neuroscience majors is growing, and a book of this type could be of great value to them. Neurology residents would find it a very quick way to get the background on which to superimpose new findings. ...Overall, I think the book does achieve the goals that Gilman proposed β€” he and his colleagues are to be congratulated." -Guy McKhann, MD, Johns Hopkins University in the NEW ENGLAND JOURNAL OF MEDICINE, May 30, 2007

Table of Contents

Part I. Central Nervous SystemSection A. Metabolic Diseases – Hugo W. Moser Chapter 1: LeukodystrophiesChapter 2: Lysosomal Disorders of the Nervous SystemChapter 3: The Neurobiology of Peroxisomal DisordersChapter 4: Creatine Deficiency SyndromesSection B. Neurodegenerative Disorders – Gregor Wenning Chapter 5: Parkinson’s DiseaseChapter 6: Alzheimer DiseaseChapter 7: Multiple System AtrophyChapter 8: Olivopontocerebellar Atrophy (OPCA)Chapter 9: Neurobiology of Progressive Supranuclear PalsySection C. Genetic Diseases – Christopher Gomez Chapter 10: Protein Aggregation DisordersChapter 11: RNA-Based Disorders of Muscle and BrainChapter 12: Ion Channel DisordersChapter 13: Spinocerebellar Ataxia Type 1Chapter 14: Shared Transcriptional Consequences of Mitochondrial Disease, Ischemic Hypoxia and Chemical HypoxiaSection D. Neuroimmunological Disorders – Anthony T. Reder Chapter 15: Paraneoplastic Neurological DisordersChapter 16: Systemic Lupus Erythematosus: Descriptive Past and Mechanistic FutureChapter 17: Progressive Multifocal LeukoencephalopathyChapter 18: Multiple SclerosisChapter 19: Immune-Mediated NeuropathiesChapter 20: Hashimoto EncephalopathySection E. Cerebrovascular Diseases – Lewis Morgenstern Chapter 21: Vascular Cognitive ImpairmentChapter 22: CardioembolismChapter 23: Coagulation DisordersChapter 24: Clinical and Neurobiological Aspects of Stroke Recovery Chapter 25: Non-Atherosclerotic Cerebral VasculopathiesChapter 26: Subarachnoid HemorrhageChapter 27: Cerebral Ischemia: Molecular Mechanisms and Protective TherapiesChapter 28: Intracerebral Hemorrhage and Intraventricular Hemorrhage-Induced Brain InjurySection F. Paroxysmal Disorders – Timothy A. Pedley Chapter 29: Idiopathic EpilepsiesChapter 30: Paroxysmal DyskinesiaChapter 31: Neurobiology of MyoclonusChapter 32: Channelopathies of the Nervous SystemChapter 33: MigraineChapter 34: Temporal Lobe EpilepsySection G. Neoplastic Diseases – John Laterra Chapter 35: CNS MetastasesRobert J. WeilChapter 36: MeningiomaKatrin Lamszus, Christian Hagel, and Manfred WestphalChapter 37: CNS LymphomaCorresponding Author: Dr. BatchelorChapter 38: Neurofibromatosis 1Linda Piersall and David H. GutmannChapter 39: Medulloblastoma and Primitive Neuroectodermal TumorsSaid Elshihabi and James T. RutkaChapter 40: GliomaAnders I. Persson, QiWen Fan, Joanna J. Phillips, and William A. WeissSection H. Infectious Diseases – Richard T. Johnson Chapter 41: Bacterial & FungalChapter 42: Parasitic InfectionsChapter 43: Prion DiseasesChapter 44: Central Nervous System Viral Infections: Clinical Aspects and Pathogenic MechanismsSection I. Motor Neuron Diseases – Eva L. Feldman Chapter 45: Spinal Muscular AtrophyChapter 46: Amyotrophic Lateral Sclerosis-Like Syndromes Associated with MalignancyChapter 47: Amyotrophic Lateral Sclerosis (ALS): Idiopathic and InheritedChapter 48: Hereditary Spastic Paraplegia and Primary Lateral SclerosisChapter 49: PoliomyelitisChapter 50: Spinobulbar Muscular Atrophy (Kennedy’s Disease)Section J. Malformations and Developmental Disorders – Michael V. Johnston Chapter 51: Neurobiology of Genetic Mental RetardationChapter 52: Cerebral PalsyChapter 53: AutismChapter 54: Neurobiology of DyslexiaChapter 55: Neonatal Brain InjuriesChapter 56: Spina BifidaChapter 57: Circuits to Synapses: The Pathophysiology of Tourette SyndromeChapter 58: Attention Deficit Hyperactivity DisorderChapter 59: Congenital Hydrocephalus Section K. Neurologic Manifestations of Medical Diseases – John J. Caronna Chapter 60: Hematological DisordersChapter 61: Renal DiseaseChapter 62: Diabetes and Endocrine DisordersChapter 63: Mechanisms and Consequences of CNS HypoxiaChapter 64: Gastroenterologic and Hepatic Diseases and Their Effects on CNSChapter 65: SarcoidosisSection L. Sleep Disorders – Emmanuel Mignot Chapter 66: REM Sleep Behavior DisorderChapter 67: The Neurobiology of Narcolepsy and HypersomniaChapter 68: Restless Legs Syndrome and Periodic Leg MovementChapter 69: Obstructive Sleep ApneaChapter 70: The Neurobiology of InsomniaSection M. Substance Abuse and Basic Toxicology – John C. M. Brust Chapter 71: Organic ChemicalsChapter 72: MetalsChapter 73: Drug AddictionSection N. Imaging the Nervous System – John C. Mazziotta Chapter 74: Assessment of Neurobiological Diseases with Magnetic Resonance SpectroscopyChapter 75: Magnetic Resonance ImagingChapter 76: Neurovascular CT AngiographyChapter 77: PET Imaging in Parkinson's Disease and Other Neurodegenerative DisordersChapter 78: Single Photon Emission Computed Tomography (SPECT)Chapter 79: Functional Magnetic Resonance Imaging (fMRI)Part II. Peripheral Nervous SystemSection O. Peripheral Neuropathies – James Russell Chapter 80: Diabetic and Metabolic NeuropathiesChapter 81: Aquired Inflammatory Demyelinating and Axonal NeuropathiesChapter 82: Toxic and Drug-Induced NeuropathiesChapter 83: Hereditary NeuropathiesChapter 84: Neurological Manifestations of VasculitisChapter 85: Neuropathies Associated with InfectionsSection P. Myopathies and neuromuscular junction disorders – Charles A. Thornton Chapter 86: The Muscular DystrophiesChapter 87: Myasthenia Gravis and Myasthenic SyndromesChapter 88: Myopathies and Neuromuscular Junction DisordersChapter 89: Immunobiology of Autoimmune Inflammatory MyopathiesSection Q. Autonomic Disorders – Phillip A. Low Chapter 90: Central Autonomic NetworkChapter 91: Autonomic NeuropathiesChapter 92: Thermoregulation and its DisordersChapter 93: Control of Blood Pressure-Normal and AbnormalSection R. Pain – Kenneth L. Casey Chapter 94: Neoplasm-Induced PainChapter 95: Pain Associated with the Autonomic Nervous SystemChapter 96: Post-Herpetic NeuralgiaChapter 97: Central Post-Stroke Pain