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Neurobiology of Alcohol Dependence
1st Edition - May 2, 2014
Editors: Antonio Noronha, Changhai Cui, Robert Adron Harris, John C. Crabbe
Language: English
Hardback ISBN:9780124059412
9 7 8 - 0 - 1 2 - 4 0 5 9 4 1 - 2
eBook ISBN:9780124071551
9 7 8 - 0 - 1 2 - 4 0 7 1 5 5 - 1
Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence hi…Read more
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Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence.
Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels
Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence
Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available
Researchers, clinicians, and advanced students in alcohol, addiction, and neuroscience research fields
Preface
Section 1: Neurocircuitry of Alcohol Dependence
Chapter 1. Frameworks of Alcohol Addiction: Alcohol Addiction as a Reward Deficit and Stress Surfeit Disorder
Abstract
Acknowledgments
Definitions and Conceptual Framework for Negative Reinforcement in Alcoholism
Motivation, Withdrawal, Opponent Process, and Compulsive Use
Animal Models for Compulsive Alcohol Seeking
Neural Substrates of the Negative Emotional State Associated With Alcoholism
Protracted Withdrawal
Stress-Induced Reinstatement
Corticotropin-Releasing Factor, Stress, and the Frontal Cortex
Cellular Mechanisms that Mediate the Neuroplasticity of the Dark Side in the Extended Amygdala
Negative Reinforcement in Alcoholism: An Allostatic View
References
Chapter 2. Cortico-Basal Ganglia Networks and the Neural Substrates of Actions
Abstract
The Problem of Motivated Behavior
Neural Basis of Motivated Behavior
Implications for Alcohol Addiction
Conclusions
References
Chapter 3. Prefrontal Limbic-Striatal Circuits and Alcohol Addiction in Humans
Abstract
Introduction
The Prefrontal-Limbic-Striatal Circuit
Acute Effects of Alcohol on the Prefrontal-Limbic-Striatal Circuit
Alcohol Addiction and Effects on the Prefrontal-Limbic-Striatal Circuit Function
Dysfunction in the PLS Circuit and Alcohol-Relapse Risk
Conclusions and Future Directions
References
Chapter 4. Molecular Adaptations in Mesolimbic Circuitry and Pathological Ethanol Intake
Abstract
Introduction
Passive versus Active Exposure Models
Ion Channels in the NAcb
Ion Channels in the VTA
GABA Receptors
Dopamine Receptors
Dopamine Release
Adaptations in the CRF System
Other Peptides and Modulators
Summary
References
Chapter 5. The Bed Nucleus of the Stria Terminalis: A Critical Site of Ethanol-Induced Alterations in Neurotransmission
Abstract
BNST Chemoarchitecture and Major Divisions
Ethanol Effects on the BNST: Known and Potential Targets
Pathways of Interest
Conclusions and Future Directions
References
Chapter 6. The Effects of Stress on Measures of Alcohol Drinking in Rodents
Abstract
Introduction
Genetic Differences in Stress Systems Contribute to Alcohol Consumption
Relationship between Withdrawal and Alcohol Consumption
Effects of Stress on Alcohol Consumption/Intake
Stress-Induced Reinstatement
Effects of Ethanol Exposure on Stress-Related Behaviors
Conclusions
References
Chapter 7. Alcohol and Developing Neuronal Circuits
Abstract
Acknowledgments
Introduction
Hippocampal Circuits
Cerebellar Circuits
Reward Pathways
Conclusions
References
Chapter 8. Human Imaging Studies of Brain Circuitry Disrupted by Alcoholism
Abstract
Acknowledgment
Introduction
The “Incomplete Lesion” as the Underlying Neuropathology of Alcoholism