Neural RegenerationEdited by
- F.J. Seil, Director, Office of Regeneration Research Programs (151N), V.A. Medical Center, Portland, OR 97201, USA
Much has happened since publication of the previous volume (71) on neural regeneration in this series in 1987. Some of the progress in research in this field is reflected in the present volume, which incorporates the proceedings of the Fifth International Symposium on Neural Regeneration held in California in December, 1993. This current volume is organized into six topic sections. Subjects covered include Neurotrophins and Receptors, Calcium and Gene Expression and Nitric Oxide in the Central Nervous System. The first chapter in each section, whose title reflects that of the section heading, is an introduction to and an overview of the topic. The highlights of the Symposium presented here reflect some of the more important recent advances in neural regeneration research, such as characterization of the increasingly complex family of the neurotrophins and their receptors, definition of the molecular mechanisms that encourage and guide axon growth, including immediate early gene activation and calcium signals, and elucidation of the many ways in which the nervous and immune systems are interactive. The section on models of spinal cord regeneration is phylogenetically organized to provide comparisons between lower animals that can and higher animals that cannot regenerate their spinal cords. There are no illusions that all aspects of neural regeneration are addressed in this volume, but the rich sample presented here should give the reader a strong sense of the excitement and the hope that have come to pervade this field.
Progress in Brain Research
Published: December 1994
- List of Contributors. Preface. Section I - Neurotrophins and Receptors. 1. Neurotrophins and receptors. 2. Axonal transport of the trkA high-affinity NGF receptor. 3. Nerve growth factor and neuronal gene expression. 4. Receptor mediated retrograde axonal transport of neurotrophic factors is increased after peripheral nerve injury. 5. Target derived and putative local actions of neurotrophins in the peripheral nervous system. 6. Distribution of acidic and basic fibroblast growth factors in the mature, injured and developing rat nervous system. Section II - Axonal Outgrowth and Pathfinding. 7. Axonal outgrowth and pathfinding. 8. Regulation of events within the growth cone by extracellular cues: tyrosine phosphorylation. 9. Regulation of growth cone motility by substratum bound molecules and cytoplasmic [Ca++]. 10. Contributions of multiple forms of myosin to nerve outgrowth. 11. Hierarchical guidance cues and selective axon pathway formation. Section III - Calcium and Gene Expression. 12. Calcium and gene expression. 13. Regulation of neurite outgrowth and immediate early gene expression by patterned electrical stimulation. 14. Nuclear calcium elevation may initiate neurite outgrowth in mammalian neurons. 15. Expression of c-June and JunD transcription factors represent specific changes in neuronal gene expression following axotomy. Section IV - Models of Spinal Cord Regeneration. 16. Models of spinal cord regeneration. 17. Functional regeneration and restoration of locomotor activity following spinal cord transection in the lamprey. 18. Spinal cord regeneration in adult goldfish: implications for functional recovery in vertebrates. 19. The lizard spinal cord: a model system for the study of spinal cord injury and repair. 20. Permissive and restrictive periods for brainstem-spinal regeneration in the chick. 21. Repair of connections in injured neonatal and embryonic spinal cord in vitro. 22. Response of rubrospinal and corticospinal neurons to injury and neurotrophins. Section V - Cross Talk between Nervous and Immune Systems in Response to Injury. 23. Cross talk between nervous and immune systems in response to injury. 24. Neurotrophins: signals between the nervous and immune systems. 25. Class I and II MHC expression and its implications for regeneration in the nervous system. 26. Neurotransmitters and cytokines in CNS pathology. 27. Cytokines and cytokine related substances regulating glial cell response to injury of the central nervous system. 28. Immune promotion of central nervous system remyelination. Section VI - Nitric Oxide in the Central Nervous System. 29. Nitric oxide in the central nervous system. 30. Nitric oxide: cellular regulation and neuronal injury. 31. Reactions of nitric oxide, superoxide and peroxynitrite with superoxide dismutase in neurodegeneration. 32. The role of free radicals in NMDA dependent neurotoxicity. 33. Regulation by neuroprotective factors of NMDA receptor mediated nitric oxide synthesis in the brain and retina.